5 questions answered from cited research · Plain language
Research shows that itch severity in systemic sclerosis generally remains stable over time rather than improving or worsening significantly as the disease progresses.
Read the full answer →Advanced nailfold videocapillaroscopy patterns (late/active) are linked to higher odds of interstitial lung disease and worse lung function in systemic sclerosis.
Read the full answer →Yes, a 2024 study found that inflammatory markers like NLR, PLR, and SII differ significantly across SSc lung phenotypes, with ILD+/PAH+ patients showing the highest levels.
Read the full answer →Screening for systemic sclerosis includes pulmonary function tests and HRCT for interstitial lung disease, nailfold capillaroscopy for Raynaud's, and autoantibody tests.
Read the full answer →Yes, RNA methylation appears to play a role in systemic sclerosis by influencing gene expression related to inflammation and fibrosis, though the exact mechanisms are still being studied.
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