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Systemic Sclerosis

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Systemic Sclerosis

31 trials tracked for Systemic Sclerosis: 6 in phase 3 or 4 and 4 with published results. The most-cited published study has 645 citations.

31Trials tracked

6Phase 3 & 4

0Recruiting

4With published results

Phase distribution

Phase 4 2 Phase 3 4 Phase 2 17 Phase 1 2 Other / NA 6

Phase 3 A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) Completed · 645 cited
Phase 4 A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis Completed · 167 cited
Phase 4 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Completed · 105 cited
Phase 3 Gastroesophageal Reflux Treatment in Scleroderma Completed · 49 cited
Phase 3 A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis Completed
Phase 3 Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients Completed

Show 25 more trials

Phase 2 Imatinib Mesylate (Gleevec) in the Treatment of Systemic Sclerosis Completed
Phase 2 Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc) Completed
Phase 2 Nilotinib in the Treatment of Systemic Sclerosis Completed
Phase 2 Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine Completed
Phase 2 Comparing and Combining Bortezomib and Mycophenolate in SSc Pulmonary Fibrosis Completed
Phase 2 IL1-TRAP, Rilonacept, in Systemic Sclerosis Completed
Phase 2 Safety and Efficacy of Oral Treprostinil in the Treatment of Calcinosis in Patients With Systemic Sclerosis Completed
Phase 2 A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis Completed
Phase 2 Effects of FT011 in Systemic Sclerosis Completed
Phase 2 A Study to Investigate Safety of GS-248 and Efficacy on Raynauds' Phenomenon in Systemic Sclerosis Completed
Phase 2 Safety and Tolerability of Pirfenidone in Participants With Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD) (LOTUSS) Completed
Phase 2 Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH) Completed
Phase 2 Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis Completed
Phase 2 An Open-label, Phase 2 Study to Assess the Efficacy and Safety of Nemolizumab in Subjects With Systemic Sclerosis Completed
Phase 2 Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis Completed
Phase 2 Cold Challenge With C21 in RP Completed
Phase 2 A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Systemic Sclerosis Completed
Phase 1 Injection of Autologous Adipose-derived Stromal Vascular Fraction in the Finger of Systemic Sclerosis Patients Completed
Phase 1 Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Sclerosis (SSc) Completed
N/A The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients Completed
N/A Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis Completed
N/A Scleroderma Patient-centered Intervention Network (SPIN) Hand Program Feasibility Study Completed
N/A The Scleroderma Patient-centered Intervention Network (SPIN) Support Group Leader Education Program Feasibility Trial Completed
N/A Evaluation of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together Program Completed
N/A Apollo Device for Fatigue in Systemic Sclerosis Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

Questions about Systemic Sclerosis

Is the severity of itch in systemic sclerosis likely to change over time?

Research shows that itch severity in systemic sclerosis generally remains stable over time rather than improving or worsening significantly as the disease progresses.

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What do nailfold videocapillaroscopy patterns mean for my lung disease in systemic sclerosis?

Advanced nailfold videocapillaroscopy patterns (late/active) are linked to higher odds of interstitial lung disease and worse lung function in systemic sclerosis.

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Do different lung types in systemic sclerosis show different inflammatory markers?

Yes, a 2024 study found that inflammatory markers like NLR, PLR, and SII differ significantly across SSc lung phenotypes, with ILD+/PAH+ patients showing the highest levels.

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What screening tests are available for patients with systemic sclerosis?

Screening for systemic sclerosis includes pulmonary function tests and HRCT for interstitial lung disease, nailfold capillaroscopy for Raynaud's, and autoantibody tests.

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Does RNA methylation play a role in my systemic sclerosis disease?

Yes, RNA methylation appears to play a role in systemic sclerosis by influencing gene expression related to inflammation and fibrosis, though the exact mechanisms are still being studied.

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See all 5 questions about Systemic Sclerosis →