Higher TG/HDL-C ratio associated with lower BMD in older adults at high elevation

This retrospective cross-sectional study included 650 older adults residing in high-elevation regions. The primary exposure was the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio, categorized into quartiles. The primary outcome was the odds of low bone mineral density (BMD), with secondary analyses examining lumbar spine and femoral neck BMD values.

main results showed that BMD values at both the lumbar spine and femoral neck were lower as the TG/HDL-C ratio increased. The direction of this relationship was an inverse association. However, the specific P-value was not reported in the text, and absolute numbers for low BMD were not provided in the available data.

No safety data, adverse events, or discontinuations were reported in this observational study. Key limitations include the cross-sectional design, which restricts the ability to infer causality, and the lack of reported P-values. Consequently, these findings should be interpreted as associations only.

The study suggests a potential relevance for supporting bone health management in high-elevation environments. Clinicians should note this association when evaluating lipid profiles and bone density in this specific population, while recognizing that further research is needed to confirm these relationships.