Phosphoproteomics technologies offer novel insights for disease diagnosis and treatment

This narrative review explores the role of phosphoproteomics technologies in advancing disease diagnosis and treatment. The authors discuss how these technologies enable the study of protein phosphorylation patterns, which can reveal disease mechanisms and potential therapeutic targets. The review highlights the promise of phosphoproteomics for identifying biomarkers and guiding personalized medicine approaches.

Key findings are qualitative, as no pooled effect sizes are reported. The authors emphasize that phosphoproteomics can uncover signaling pathway alterations that are not apparent through other methods. However, the field faces significant challenges, including limited sensitivity for detecting low-abundance signals, throughput constraints of single-cell technologies, and the absence of standardized workflows.

These limitations currently restrict the clinical applicability of phosphoproteomics. The review does not provide specific recommendations for practice but suggests that further technological advancements and standardization are needed before widespread clinical adoption. Clinicians should interpret these findings as preliminary and recognize that phosphoproteomics remains a research tool rather than a routine diagnostic modality.