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Minimally invasive pulse wave analysis exceeds 30% error threshold for cardiac output and indexPulse Wave Analysis Shows High Error in Measuring Cardiac Output

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Key Takeaway
Note that pulse wave analysis exceeds the 30% error threshold for clinically acceptable agreement in circulatory shock.

This systematic review and meta-analysis evaluated the diagnostic accuracy of minimally invasive pulse wave analysis compared to reference measurements, such as pulmonary artery thermodilution or transpulmonary thermodilution, in 3111 adult surgical or critically ill patients. The analysis synthesized data from 92 studies and 113 data sets to assess cardiac output and cardiac index.

The meta-analysis found a pooled percentage error of 44.0% (95% CI [38.2%-49.8%]) for cardiac output and 49.1% (95% CI [40.6%-57.6%]) for cardiac index. The mean difference for cardiac output was -0.1 (1.3) L min with 95% limits of agreement from -2.6 to 2.4 L min. For cardiac index, the mean difference was -0.1 (0.9) L min m with 95% limits of agreement from -1.8 to 1.6 L min m.

A primary limitation noted by the authors is that percentage error varied substantially across different patient populations and specific devices. Because the pooled percentage errors for both cardiac output and cardiac index exceed the 30% threshold, the clinical reliability of these measurements may be limited in perioperative and intensive care settings.

Researchers analyzed data from 92 studies involving over 3,000 critically ill and surgical patients. The goal was to see if a minimally invasive method called pulse wave analysis could accurately measure cardiac output—the amount of blood the heart pumps each minute—compared to standard reference methods.

The results showed significant discrepancies. The study found a 44% error rate for cardiac output and a 49.1% error rate for cardiac index. Because these figures are much higher than the 30% threshold usually required for medical reliability, the findings suggest that this specific technology may not be precise enough for clinical use at this time.

While the study had a low risk of bias, the accuracy varied significantly depending on the type of device used and the specific patient group. Because the error rates are high, doctors should continue to rely on established monitoring methods for patients in critical condition.

What this means for you:
Pulse wave analysis currently shows high error rates and may not be reliable enough for clinical use yet.

Common questions

Is pulse wave analysis accurate enough for use in hospitals?

The study found that the error rates for cardiac output (44.0%) and cardiac index (49.1%) were both above the 30% threshold needed for clinical acceptance. This means the method may not be reliable enough to replace standard monitoring tools for critically ill patients at this time.

How many patients were included in this study?

The analysis looked at data from 3,111 adult surgical or critically ill patients. This large sample size allowed researchers to compare pulse wave measurements against standard reference methods across various clinical settings.

Why is the accuracy of these devices inconsistent?

The study noted that the percentage error varied significantly depending on both the specific patient population and the type of device being used. Because of these variations, clinicians should be cautious when interpreting results from pulse wave analysis.

Study Details

Study typeMeta analysis
Sample sizen = 3,111
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BACKGROUND: Cardiac output monitoring is recommended for high-risk surgical patients and critically ill patients with circulatory shock. We performed a systematic review and meta-analysis of clinical studies published since 2010 that compared minimally invasive pulse wave analysis-derived cardiac output or cardiac index measurements with reference measurements by pulmonary artery thermodilution or transpulmonary thermodilution in adult surgical or critically ill patients. METHODS: In a random-effects meta-analysis, we calculated pooled estimates of the percentage error, mean difference and standard deviation, and 95% limits of agreement separately for studies reporting cardiac output or cardiac index. Subgroup analyses were performed by patient population and test device. RESULTS: We included 92 studies divided into 113 data sets with a total of 3111 patients. For 71 data sets reporting cardiac output, the pooled percentage error (95% confidence interval [95% CI]) was 44.0% (38.2%-49.8%) with a mean difference (standard deviation) of -0.1 (1.3) L min with 95% limits of agreement of -2.6 to 2.4 L min (I=9.8%). For 42 data sets reporting cardiac index, the pooled percentage error was 49.1% (40.6%-57.6%) with a mean difference of -0.1 (0.9) L min m with 95% limits of agreement of -1.8 to 1.6 L min m (I=7.9%). The percentage error varied substantially across patient populations and devices. Overall risk of bias was low. CONCLUSIONS: The pooled percentage error between minimally invasive pulse wave analysis-derived cardiac output measurements of 44.0% (cardiac output) and 49.1% (cardiac index) in adult surgical or critically ill patients exceeds the 30% threshold for clinically acceptable agreement. However, the percentage error varied depending on the patient population and device used. TRIAL REGISTRATION: PROSPERO (CRD420251090806; submitted July 17, 2025).
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