Mode
Text Size
Log in / Sign up

Higher pretreatment HALP score is associated with improved overall survival in head and neck cancerHigher HALP scores linked to better survival in head cancer

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note that higher pretreatment HALP scores are associated with improved survival in head and neck cancer patients.

This meta-analysis evaluated the prognostic value of the pretreatment haemoglobin-albumin-lymphocyte-platelet (HALP) score in patients with head and neck cancer. The analysis included a total of 1759 patients to assess the correlation between HALP scores and survival outcomes.

The meta-analysis found that a higher pretreatment HALP score was associated with improved overall survival (effect size 0.52; 95% CI 0.41-0.67). When excluding the metastatic cohort, the association with improved overall survival remained significant (effect size 0.56; 95% CI 0.45-0.70). Additionally, higher pretreatment HALP scores were associated with improved disease-free survival (effect size 0.60; 95% CI 0.47-0.76).

A noted limitation of this evidence is the inconsistent reported cutoff values for HALP across the included studies. While the association between HALP and survival is statistically significant, the lack of standardized cutoffs may impact the clinical application of the score. Clinicians may find the HALP score useful for evaluating the prognosis of patients with head and neck cancer, but results should be interpreted as an association rather than a causal link.

How this fits prior evidence

This meta-analysis addresses a gap in identifying prognostic biomarkers for head and neck cancer. It complements existing evidence regarding the impact of nutritional status and physical condition on outcomes, such as the finding that malnutrition and sarcopenia are associated with higher toxicity and poorer outcomes in head and neck cancer. While the HALP score focuses on a combination of inflammation and nutrition, it provides a different metric than the C3-derived skeletal muscle index or the assessment of sarcopenia for dysphagia risk.

When a patient is diagnosed with head and neck cancer, doctors look for any signs that can help predict how the disease will progress. A new look at data from 1,759 patients suggests that a specific blood measurement called the HALP score could provide that clarity. This score combines levels of hemoglobin, albumin, lymphocytes, and platelets to give a snapshot of a patient's health.

The analysis found that patients with a higher HALP score before starting treatment had better overall survival rates. It also showed that these patients had better disease-free survival, meaning the cancer stayed away for longer periods. These results remained consistent even when looking specifically at patients whose cancer had not yet spread to other parts of the body.

While this score is a helpful tool for doctors to evaluate a patient's outlook, there are still some hurdles. Different studies used different cutoff points to decide what a "high" score actually was. Because this was an observational analysis and not a clinical trial, it shows a link between the score and survival rather than a direct cause. It is a helpful piece of the puzzle for doctors managing head and neck cancer.

What this means for you:
Higher HALP blood scores are linked to better survival and longer disease-free periods in head and neck cancer.

Common questions

What is a HALP score and how does it help?

HALP is a score based on four parts of your blood: hemoglobin, albumin, lymphocytes, and platelets. It helps doctors get a better picture of your overall health and nutrition. In this study of 1,759 patients, a higher HALP score before treatment was linked to better overall survival and longer periods of being disease-free.

Does a higher HALP score mean a better outcome for cancer patients?

The data shows that patients with higher pretreatment HALP scores had better overall survival. This remained true even when looking at patients whose cancer had not spread. However, this was an observational study, meaning it shows a link between the score and survival, not a direct cause.

Are there any limitations to using the HALP score?

One main challenge is that different studies used different cutoff values to determine what counts as a high or low score. Because of these inconsistent values, doctors must use the score carefully as one of many tools to help evaluate the prognosis for patients with head and neck cancer.

Study Details

Study typeMeta analysis
Sample sizen = 1,759
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
OBJECTIVES: The haemoglobin-albumin-lymphocyte-platelet (HALP) score is an inflammation- and nutrition-related biomarker derived from routine blood tests, but its prognostic value in head and neck cancer (HNC) has not been quantitatively synthesized. This systematic review and meta-analysis aimed to evaluate the association between pretreatment HALP and survival outcomes in HNC. METHODS: PubMed, Embase and Web of Science were searched to 24 January 2026 for cohort studies reporting hazard ratios (HRs) for survival outcomes by pretreatment HALP in HNC. Reviews, case reports, conference abstracts without full text, and studies lacking survival data were excluded. Random-effects meta-analysis was performed and risk of bias was assessed using QUIPS. The review was prospectively registered in the Open Science Framework. RESULTS: Six retrospective cohort studies (1759 patients) were included. Higher pretreatment HALP was associated with improved overall survival (pooled HR 0.52, 95% CI 0.41-0.67; I = 17.6%) and disease-free survival (pooled HR 0.60, 95% CI 0.47-0.76; I = 0.0%). After excluding the metastatic cohort, the pooled overall survival estimate remained similar (HR 0.56, 95% CI 0.45-0.70; I = 0.0%), and leave-one-out analyses showed stable estimates (HR range 0.48-0.56). CONCLUSIONS: Higher pretreatment HALP is associated with favourable survival in HNC. However, reported cutoff values for HALP have been inconsistent across studies. HALP might be helpful for clinicians in evaluating the prognosis of HNC patients.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.