Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
New Research Tools Help Map Complex Oral Diseases
This mini-review examines the integration of advanced experimental models, such as organ-on-chip systems and patient-derived organoids, with…
Advanced modeling and AI tools are helping researchers better understand the molecular causes behind conditions like gum disease and oral ca…
Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
Microbial metabolites may drive cancer growth or stop it through inflammation and DNA damage
This narrative review examines the role of microbial metabolites in carcinogenesis and cancer progression across multiple malignancies. The …
Microbial metabolites can promote cancer growth via inflammation or suppress it through immune changes, but we need more proof before using …
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
Local brain treatments linked to modest survival gains in rare head and neck cancer cases
This retrospective cohort analysis evaluated 201 patients with head and neck squamous cell carcinoma and brain metastasis from three tertiar…
Local brain treatments linked to lower death risk for rare head and neck cancer patients who develop brain metastases, though most still die…
Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
Early trial shows new cancer drug combo helps some patients with advanced disease
This Phase 1, first-in-human dose-expansion study evaluated fianlimab 1600 mg plus cemiplimab 350 mg in patients with advanced non-small cel…
A new drug combination helped some patients with advanced lung, kidney, head and neck, or skin cancer shrink their tumors in early testing.
Molecular markers may improve risk assessment in oral potentially malignant disorders
Molecular tools may improve risk assessment for oral lesions
This narrative review examines the limitations of conventional histopathological grading for oral potentially malignant disorders (OPMDs) an…
A review suggests molecular methods could better assess risk for oral potentially malignant disorders where standard grading is unreliable.
Aspiration pneumonia affects 74.8% of head and neck cancer patients after chemoradiotherapy
Aspiration pneumonia strikes most head and neck cancer patients after chemoradiation
This supplementary analysis of a phase II/III trial in Japan found that 74.8% of 151 patients with resected high-risk head and neck cancer d…
Three in four head and neck cancer patients develop aspiration pneumonia after chemoradiation. Severe swallowing problems and reconstruction…
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
Radiation for head and neck cancer may raise sleep apnea risk
This scoping review with exploratory meta-analysis of 13 studies found no significant association between radiotherapy or chemotherapy and i…
A review of 13 studies suggests a possible link between radiation for head and neck cancer and mild sleep apnea, but the evidence is too wea…
20-fraction hypofractionated radiotherapy passes noninferiority for tumor control and late toxicity in locally advanced head and neck cancer
Shorter radiation schedule works as well for head and neck cancer
This randomized, open-label, Phase 3 noninferiority trial enrolled 792 patients with locally advanced head and neck squamous cell carcinoma …
A shorter radiation plan for head and neck cancer showed the same effectiveness as a longer schedule while reducing late side effects.
Robot-assisted oesophagectomy shows non-inferior survival in oesophageal squamous cell carcinoma
Robot-assisted surgery may improve survival for oesophageal cancer patients
A randomised trial compared robot-assisted versus thoracoscopic oesophagectomy for resectable oesophageal squamous cell carcinoma. The autho…
A large trial found robot-assisted oesophagectomy linked to higher five-year survival than thoracoscopic surgery for oesophageal squamous ce…
Immune checkpoint blockade shows promise but faces resistance challenges in nasopharyngeal carcinoma
Immune checkpoint blockade may help treat nasopharyngeal carcinoma
This narrative review examines immune checkpoint blockade in nasopharyngeal carcinoma. It highlights that while 5-year overall survival for …
A narrative review suggests immune checkpoint blockade could guide new treatments for nasopharyngeal carcinoma, though resistance remains a …
Scoping review of AI for head and neck cancer risk stratification
AI techniques show promise for staging head and neck cancer
This scoping review synthesized 44 studies on AI techniques for risk stratification in head and neck cancer. The authors found moderate to h…
A review of 44 studies suggests artificial intelligence could help predict cancer spread in head and neck cases, though more testing is need…
Case report review highlights suspicion of breast cancer metastasis to thyroid in a 54-year-old woman
Breast cancer can spread to the thyroid gland in rare cases
This case report review describes a 54-year-old woman with a history of breast cancer who developed metastasis to the thyroid. The authors n…
A single case report shows a 54-year-old woman survived after breast cancer spread to her thyroid, highlighting the need for careful diagnos…
Research across Cancer
Related studies from across the Cancer family.
Narrative review covers diagnostic and treatment strategies for metastatic head and neck cancer with no identifiable primary tumor
Doctors use many tools to treat head and neck cancer when the main tumor is hidden
This narrative review addresses diagnostic and treatment strategies for metastatic cases of head and neck cancer with no identifiable primar…
When head and neck cancer spreads but the original spot is missing, doctors use many tools. Imaging, special tests, and surgery help find th…
SABR Protocol Deviations Linked to Poorer Survival in Oligometastatic Head and Neck Cancer
Major protocol deviations cut survival time for head and neck cancer patients
This exploratory analysis of a randomized phase 2 trial (GORTEC 2014-04) in 69 patients with oligometastatic head and neck cancer found that…
Strict radiation quality checks linked to better survival for head and neck cancer patients. Minor or major errors during treatment reduced …
In a prospective cohort, periampullary tumor surgery affected quality of life and survival metrics
Life After Major Cancer Surgery Isn’t What We Thought
This prospective cohort study evaluated 111 patients undergoing pancreaticoduodenectomy for periampullary tumors at a University Medical Cen…
Imagine waking up after major cancer surgery.
Case report suggests grade 3 ICI-induced inflammatory arthritis may correlate with sustained response to tislelizumab in advanced head and neck carcinoma
Could a painful joint flare actually signal that cancer treatment is working long-term?
This case report and literature review describes a single patient with advanced unknown primary carcinoma of the head and neck receiving mai…
A patient with advanced head and neck cancer stayed in complete remission for over a year after joint pain from treatment forced doctors to …
Questions about Head and Neck Cancer
What is the risk of acute kidney disease for head and neck cancer patients treated with cisplatin?
Cisplatin-based chemoradiotherapy in head and neck cancer carries a high risk of acute kidney injury, with reported incidences ranging from 20% to 69% depending on the cisplatin regimen and patient factors.
Full answer →All Head and Neck Cancer Articles
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
- Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
- Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
- Aspiration pneumonia affects 74.8% of head and neck cancer patients after chemoradiotherapy
- 20-fraction hypofractionated radiotherapy passes noninferiority for tumor control and late toxicity in locally advanced head and neck cancer
- Robot-assisted oesophagectomy shows non-inferior survival in oesophageal squamous cell carcinoma
- Immune checkpoint blockade shows promise but faces resistance challenges in nasopharyngeal carcinoma
- Scoping review of AI for head and neck cancer risk stratification
- Case report review highlights suspicion of breast cancer metastasis to thyroid in a 54-year-old woman
- Narrative review covers diagnostic and treatment strategies for metastatic head and neck cancer with no identifiable primary tumor
- Evidence mapping review on nutritional prehabilitation for head and neck cancer patients
- Case report and review: IVIg and efgartigimod in Guillain-Barré with Graves disease and thyroid cancer
- Systematic review and meta-analysis on immunotherapy for head and neck squamous cell carcinoma
- FDA approves OPDIVO QVANTIG for multiple advanced cancer indications including renal cell carcinoma and melanoma
- Meta-analysis finds sex-based differences in ICI survival benefit for advanced gastroesophageal cancer
- Systematic review and meta-analysis of ML with cfDNA for cancer detection across stages
- Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
- Review of 32 cases of thyroid hemiagenesis with carcinoma highlights surgical and diagnostic patterns
- Oropharyngeal cancer radiotherapy protocols show improved patient-reported outcomes over time
- Meta-analysis finds BCI_net prognostic for overall survival in oral squamous cell carcinoma
- Review links mature intra-tumoral TLS to better prognosis and immunotherapy response in head and neck cancer
- Narrative review on therapeutic cancer vaccines for head and neck squamous cell carcinoma
- Narrative review explores Veillonella's dynamic role in oral squamous cell carcinoma
- Meta-analysis of postoperative radiotherapy versus radiochemotherapy for salivary gland cancer finds no significant survival difference
- Review of epigenetic dysregulation in nasopharyngeal carcinoma management
- Early time-of-day immune checkpoint inhibitor administration improves overall survival in advanced solid tumors
- Meta-analysis shows neoadjuvant chemoradiation improves resection and survival outcomes for esophageal squamous cell carcinoma patients compared to chemotherapy alone
- Narrative review discusses HPV-associated head and neck and cervical squamous cell carcinoma without reporting specific outcomes
- Review of multimodal deep learning model for esophageal squamous cell carcinoma diagnosis
- SABR Protocol Deviations Linked to Poorer Survival in Oligometastatic Head and Neck Cancer
- Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery
- SIB-RT plus S-1 improves survival in elderly inoperable esophageal cancer
- GERD Associated with Increased Risk of Laryngeal Cancer in Meta-Analysis
- Meta-analysis finds frozen section reliable for tumor-free margins in OSCC
- Review of PBMC processing conditions in head and neck squamous cell carcinoma treatment-naive patients
- Narrative review discusses targeting ferroptosis and cuproptosis in oral squamous cell carcinoma
- Pre-treatment body composition and acute kidney disease risk in head and neck cancer patients treated with cisplatin
- Comprehensive salivary gland–sparing helical tomotherapy reduces radiation-induced xerostomia in nasopharyngeal carcinoma patients
- Machine learning model predicts central lymph node metastasis in papillary thyroid carcinoma
- Deep learning segmentation with CT elasticity features predicts right recurrent laryngeal nerve metastasis in esophageal cancer
- Iron and oxidative stress biomarkers linked to oral cancer recurrence after surgery
- TIRADS and Bethesda systems predict thyroid malignancy in 70 patients at Baghdad Teaching Hospital
- Preclinical deep learning framework shows improved dose prediction for unseen cancer sites
- Neoadjuvant Chemoimmunotherapy Alters Tumor Microenvironment in Esophageal Cancer
- Case series describes four clear cell variant papillary thyroid carcinoma cases with NCOA4-RET fusions
- Personalized swallowing rehab improves outcomes after oral cancer surgery
- Phase III trial indicates ultra-low-dose nivolumab may improve survival over chemotherapy in advanced solid tumors
- Nomogram model using NLR, age, and ultrasound features discriminates papillary thyroid carcinoma from benign nodules
- High NSUN3 expression linked to poor survival in oral squamous cell carcinoma
- Meta-analysis of oxidative stress markers in oral leukoplakia versus healthy controls
- EBNA1 SeroStrip-HT shows high accuracy for nasopharyngeal carcinoma risk assessment in a nested case-control study
- Autopsy study finds 55% thyroid nodular disease prevalence in Mexico City hospital patients
- Becotatug vedotin shows 20.9% objective response in recurrent head and neck squamous cell carcinoma after prior therapy
- Meta-analysis of 7,750 saliva samples validates non-invasive disease prediction models for nasopharyngeal carcinoma, colorectal cancer, and PLHIV
- Mini review examines genetic polymorphisms and viral markers linked to nasopharyngeal carcinoma risk
- Classification framework shows 79% to 98% performance for oral squamous cell carcinoma on histopathological images
- Review links oral microbiome dysbiosis to malignant transformation in oral lichen planus
- Radiotherapy de-escalation strategies show reduced toxicity but modest clinical benefits in head and neck cancer cohorts
- Phase 1b ABBV-368 combinations in recurrent/metastatic HNSCC show 14.3% overall response rate
- Timing of surgery after neoadjuvant chemoimmunotherapy impacts survival in operable esophageal squamous cell carcinoma
- Intravenous vitamin C did not reduce gastrointestinal toxicities but attenuated platelet decline in nasopharyngeal carcinoma patients
- Phase 3 trial compares IMPT versus IMRT plus cisplatin in locally advanced oropharyngeal squamous cell carcinoma
- Low OT-NLR predicts superior survival in recurrent/metastatic HNSCC treated with cetuximab plus nivolumab
- Penpulimab plus chemotherapy significantly improved progression-free survival in recurrent or metastatic nasopharyngeal carcinoma
- Anti-PD-1 plus chemoradiotherapy improved event-free survival in MS1 subtype nasopharyngeal carcinoma patients compared with chemoradiotherapy alone
- Frozen visual encoders compared for thyroid nodule classification in the ThyroidEffi 1.0 dataset
- Becotatug vedotin shows antitumor activity in pretreated recurrent or metastatic nasopharyngeal carcinoma
- MRLN sparing radiotherapy shows non-inferior survival, reduced toxicity in nasopharyngeal carcinoma
- Breg-related gene signature predicts survival and immune landscape in head and neck squamous cell carcinoma
- Sedentary time, insomnia, and weight linked to high-risk thyroid nodules in retrospective cohort
- BRAFV600E mutation testing shows diagnostic value in high-suspicion thyroid nodules with non-malignant cytology
- Topical dexamethasone mouthwash reduces oral mucositis severity in head and neck cancer radiotherapy patients
- Exercise improves functional capacity and quality of life in head and neck cancer survivors
- Regional motif diversity score in cfDNA predicts pembrolizumab response in head and neck cancer
- Deep learning model using preoperative CT predicts lymph node metastasis in papillary thyroid carcinoma
- TyG-BMI index shows positive association with papillary thyroid carcinoma odds in Chinese cohort
- Green tea mouth rinse improved oral health scores but not pain or QOL in advanced head and neck cancer patients
- Machine learning algorithm predicts skip metastasis in papillary thyroid cancer in retrospective cohort
- Meta-analysis finds Qi-deficiency constitution most prevalent in nasopharyngeal carcinoma health states
- Phase 3 trial compares pembrolizumab with or without lenvatinib in PD-L1+ recurrent/metastatic HNSCC
- PD-1 inhibitors + chemo improve OS, PFS, ORR in first-line advanced ESCC; benefit limited in PD-L1 CPS <1
- Meta-analysis: PD-1/PD-L1 inhibitors show 45% ORR, 16.27-month median OS in recurrent/metastatic NPC
- Photobiomodulation reduces severe oral mucositis (RR 0.46) and pain (RR 0.35) in head and neck cancer patients