FDA approved Glucagon for Injection as Diagnostic Aid During Radiologic ExaminationsFDA approved Glucagon to Help Keep the Gut Still During Imaging

Glucagon for Injection is a gastrointestinal motility inhibitor. Its mechanism of action is not described in the label.

Glucagon for Injection is indicated for use as a diagnostic aid during radiologic examinations to temporarily inhibit movement of the gastrointestinal tract. It is not indicated for the emergency treatment of hypoglycemia because it is not packaged with a syringe and diluent necessary for rapid preparation and administration during an emergency outside of a healthcare facility. The patient population is not further specified in the label.

Reconstitute lyophilized powder with Sterile Water for Injection before use. Determine dose based on diagnostic procedure, route of administration, and procedure duration. To inhibit stomach and small bowel motility, the dose is 0.2 mg to 0.5 mg given intravenously or 1 mg given intramuscularly. To inhibit colon motility, the dose is 0.5 mg to 0.75 mg given intravenously or 1 mg to 2 mg given intramuscularly. Bolus doses above 1 mg administered intravenously have caused nausea and vomiting and are not recommended. Reconstitute by injecting 1 mL of Sterile Water for Injection into the vial, shake gently until dissolved, and inspect for particulate matter and discoloration. The reconstituted solution has a concentration of approximately 1 mg per mL and should be used immediately. Administer by medical personnel. If given intravenously, administer as a bolus over 1 minute. Discard any unused portion. After the procedure, give oral carbohydrates to patients who have been fasting, if compatible with the diagnostic procedure.

Trial data not available in label.

Glucagon for Injection is contraindicated in patients with pheochromocytoma because of the risk of increased blood pressure, and in patients with insulinoma or glucagonoma because of the risk of hypoglycemia. Drug interactions include beta-blockers; the clinical impact is described in the label but not fully detailed here.

Glucagon for Injection is approved as a diagnostic aid for radiologic examinations to temporarily inhibit GI motility. It is not for emergency hypoglycemia treatment. Its place in therapy is as a procedural adjunct, with dosing tailored to the specific examination and route.