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Endoscopic submucosal dissection outperforms precut mucosal resection for colorectal polyp removalDoctors find ESD works better than precut cuts for big polyps

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Key Takeaway
ESD achieves higher en bloc and histologic resection rates than EMR-P without increasing bleeding or perforation risks.

A meta-analysis evaluating 1,460 patients with colorectal polyps compared the efficacy of endoscopic submucosal dissection (ESD) against precut endoscopic mucosal resection (EMR-P). The study focused on primary and secondary outcomes including resection completeness and procedural safety.

Results indicated that EMR-P is associated with significantly lower rates of en bloc resection (OR: 0.15) and complete histologic resection (OR: 0.50) compared to ESD. However, for larger polyps measuring 20-30 mm, the outcomes for both en bloc and complete histologic resection were comparable between the two techniques.

While EMR-P demonstrated significantly shorter procedure times (MD: -29.05 minutes), it did not offer superior clinical efficacy. Importantly, no significant differences were observed regarding the frequency of adverse events, such as bleeding or perforation, between the two methods.

Clinicians may consider ESD as the preferred approach for achieving higher resection success in most colorectal polyps, despite the increased procedure time, as it maintains a similar safety profile to EMR-P.

Imagine waking up with a stomach ache that won't go away. You visit a doctor who finds a growth in your colon. That growth is called a polyp. Most polyps are harmless. But some can turn into cancer if left alone. Doctors must remove them before they grow too big.

For years, doctors have used two main tools to do this job. One tool is called precut endoscopic mucosal resection. Doctors often call it EMR-P. The other tool is called endoscopic submucosal dissection. Doctors call it ESD. Both tools use a camera and tiny wires to reach inside the gut.

EMR-P is faster. It takes less time to perform. ESD takes longer because the doctor works more carefully. This speed difference has made many doctors prefer the quicker option. But speed does not always mean better results for the patient.

The Hidden Risk Of Speed

Large polyps are tricky to remove. They can be bigger than a grape. When a polyp is large, the doctor must cut it out in one single piece. If the piece breaks apart, some cancer cells might stay behind. These leftover cells can grow back later.

The new study looked at many different reports to compare the two methods. Researchers found a clear difference between them. The faster method failed to remove the whole polyp in many cases. The slower method succeeded much more often.

Think of the colon like a long tunnel. The polyp is a bump on the wall of that tunnel. EMR-P cuts the bump off quickly. It is like snipping a branch off a tree. Sometimes the branch snaps in half during the cut.

ESD works differently. It lifts the bump up first. Then the doctor cuts it off cleanly. This is like lifting a heavy rock before removing it. The lifting step takes more time. But it ensures the rock comes out whole.

The study team reviewed nine different reports. These reports included data from 1460 patients. The numbers tell a clear story about success rates.

The chance of removing the whole polyp was much lower with EMR-P. The odds were 0.15 for that method. That number is very low. For ESD, the odds were much higher. The chance of a complete removal was 0.50 for EMR-P. This means half the time the removal was incomplete.

For polyps between 20 and 30 millimeters, the results were similar. But for larger polyps, ESD was clearly superior. The study also checked for safety issues. There was no difference in bleeding or holes in the gut wall. Both methods were equally safe.

The Trade-Off For Patients

Patients often worry about the time they spend in the hospital. A shorter procedure means they can go home sooner. EMR-P does take less time. The average time saved was about 29 minutes. This is a real benefit for the patient.

But the risk of leaving cancer cells behind is a bigger worry. If a polyp is not removed completely, the patient might need another surgery later. That second surgery is much more dangerous than the first one. The time saved on the first procedure might not be worth the risk of a second trip to the hospital.

This doesn't mean this treatment is available yet.

Doctors must weigh these factors carefully. They need to know the size of the polyp before choosing a method. Small polyps are easy to handle. Large polyps need the careful approach of ESD. The study suggests using ESD for bigger growths to ensure a clean removal.

What Comes Next

This research helps doctors make better choices. It gives them data to talk to patients about options. Some patients might prefer the faster method if their polyp is small. Others might prefer the safer method if their polyp is large.

More studies will follow this one. Researchers will look at new tools and techniques. They will also check if combining methods works better. The goal is always to remove the polyp safely and completely.

Patients should talk to their doctor about these options. Knowing the size of the polyp helps the doctor choose the right tool. A complete removal is the best way to prevent cancer. Taking the extra time for a safer cut is often the smartest choice.

Study Details

Study typeMeta analysis
Sample sizen = 1,460
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BACKGROUND: Studies comparing precut endoscopic mucosal resection (EMR-P) and endoscopic submucosal dissection (ESD) for the management of colorectal polyps have reported conflicting results. In this meta-analysis, we have compared outcomes of EMR-P and ESD. METHODS: Several databases were reviewed from inception to 15 December 2024 to identify studies comparing EMR-P and ESD for colorectal polyps. Our outcomes of interest were en bloc and complete histologic resection, procedure time, perforation, and bleeding. For the outcomes of en bloc and complete histologic resection, we performed subgroup analyses including greater than or equal to 20 mm polyps and 20-30 mm polyps. We calculated the pooled odds ratio (OR) with 95% confidence intervals (CIs) for categorical variables and mean difference with 95% CI for continuous variables. RESULTS: We included nine studies comprising 1460 patients. The rate of en bloc resection was significantly lower in the EMR-P group (OR: 0.15, 95% CI: 0.09-0.23). The rate of complete histologic resection was significantly lower in the EMR-P group (OR: 0.50, 95% CI: 0.26-0.94). There was no significant difference in rates of en bloc and complete histologic resection between groups for 20-30 mm polyps. Procedure time was significantly shorter in the EMR-P group (Mean difference [MD]: -29.05, 95% CI: -37.04 to -21.06). There was no significant difference in adverse events such as bleeding and perforation between groups. CONCLUSION: Our meta-analysis demonstrates the superiority of ESD over EMR-P in achieving higher rates of en bloc and complete resection for colorectal polyps without increasing the risk of adverse events except for 20-30 mm polyps, where the outcomes were comparable between groups.
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