Review analyzes genome editing innovations for plant biotechnology and crop improvement

This systematic review provides a critical analysis of recent developments in genome editing technologies—including CRISPR/Cas9, base editing, and prime editing—for applications in plant biotechnology and crop improvement. The review focuses on methodological innovations, such as dual pegRNA strategies and site-specific integrases, that have expanded the potential of prime editing for precise gene insertions in plants. No specific plant species, genes, or breeding results are quantified, and no statistical measures of editing efficiency or specificity are provided.

No clinical outcomes, safety data, or efficacy data from human or animal trials are reported. Adverse events, serious adverse events, discontinuations, and tolerability are not reported. The review does not include information about study population, sample size, setting, comparator, primary or secondary outcomes, or follow-up duration.

Key limitations include the absence of quantitative data and the fact that this is a review article summarizing existing literature rather than presenting new experimental findings. Funding sources and conflicts of interest are not reported. The practice relevance for clinical medicine is not reported, as this review focuses on technological developments in plant biotechnology rather than clinical applications.

For clinicians, this review serves as an overview of technological advancements in genome editing for agricultural applications. It does not provide evidence relevant to human therapeutics or clinical practice. The certainty of the information is limited by its nature as a literature review without new experimental data.