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Apodemus mice are key reservoirs for Borrelia and Neoehrlichia, but landscape drives tick-borne pathogen riskMice Spread Tick-Borne Diseases in Europe, Review Finds

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Key Takeaway
Consider Apodemus mice as confirmed reservoirs for Borrelia and Neoehrlichia, but recognize that landscape and climate drive broader pathogen risk.

This narrative review synthesizes evidence on the role of European Apodemus spp. (wood mice) in the ecology of tick-borne zoonotic pathogens. The authors examine how ecological context, host demography, population density, community composition, habitat configuration, climatic variability, landscape structure, forest cover, temperature, urbanization, and land-use change influence reservoir competence and transmission cycles.

Key findings indicate that Apodemus spp. function as confirmed reservoir hosts for some agents, particularly certain Borrelia genospecies and Neoehrlichia mikurensis. However, their contribution to other transmission cycles is ecotype-dependent, indirect, or context-specific. Landscape structure, forest cover, and temperature-related variables emerge as key large-scale predictors of tick-borne pathogen incidence.

The authors note marked heterogeneity in species-specific epidemiological roles across pathogens as a limitation. They caution that infection prevalence alone does not equate to reservoir competence.

Practice relevance lies in adopting a One Health perspective that considers rodent ecology, vector biology, and environmental change in concert. The review underscores the complexity of tick-borne disease ecology and the need for context-specific risk assessment.

A new review of research on European wood mice and yellow-necked mice, known as Apodemus species, confirms that these rodents are important hosts for certain tick-borne germs. The review looked at dozens of studies to understand how these mice contribute to the spread of diseases like Lyme disease and Neoehrlichiosis.

The findings show that Apodemus mice are confirmed reservoirs for some Borrelia bacteria and for Neoehrlichia mikurensis. However, their role in spreading other tick-borne pathogens is not straightforward. It depends on the local environment, including the type of landscape, how many other animals are around, and the climate.

Key factors that predict higher tick-borne disease risk include forest cover, temperature, and landscape structure. The review highlights that simply finding the germ in a mouse does not mean the mouse is a good spreader. Other factors, such as the mouse's population density and the presence of other hosts, matter a lot.

This review is a summary of existing studies, not a new experiment. The authors caution that the role of these mice varies greatly across different pathogens and regions. The main takeaway is that controlling tick-borne diseases requires looking at the whole picture: the mice, the ticks, the environment, and human activity.

What this means for you:
Mice spread some tick-borne diseases, but their role depends on local ecology, not just infection.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Rodents of the genus Apodemus are among the most widespread and abundant small mammals in Europe and play a central role in the ecology of numerous zoonotic pathogens. Owing to their ecological plasticity, high population densities, and frequent infestation by arthropod vectors, Apodemus species contribute to the maintenance and transmission of a diverse array of bacterial, viral, and protozoan agents of public health concern. This narrative review synthesises current knowledge on vector-borne pathogens associated with European Apodemus spp. and highlights marked heterogeneity in species-specific epidemiological roles across pathogens. We highlight marked heterogeneity in the epidemiological roles of Apodemus spp. across pathogens. While they function as confirmed reservoir hosts for some agents, particularly certain Borrelia genospecies and Neoehrlichia mikurensis, their contribution to other transmission cycles is ecotype-dependent, indirect, or context-specific. Infection dynamics are shaped by host demography, population density, community composition, habitat configuration, and climatic variability, which together modulate vector abundance, host-vector contact rates, and environmental persistence. Importantly, infection prevalence alone does not equate to reservoir competence; instead, pathogen-specific life histories and ecological context determine the extent to which Apodemus spp. amplify or bridge transmission. Landscape structure, forest cover, and temperature-related variables emerge as key large-scale predictors of tick-borne pathogen incidence, linking rodent ecology to human disease risk. Urbanisation and land-use change further reorganise host–vector networks, creating novel interfaces for spillover. By integrating multi-pathogen evidence across ecological scales, this review underscores the importance of adopting a One Health perspective that considers rodent ecology, vector biology, and environmental change in concert. Understanding the context-dependent role of Apodemus spp. is essential for anticipating future zoonotic risk under ongoing climatic and landscape transformation.
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