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Regenerative endodontic procedures may lead to unusual root morphology in immature teethRegenerative procedures can lead to unusual tooth root growth

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Key Takeaway
Note that regenerative endodontic procedures may result in unusual root morphology, especially with pre-existing inflammation or orthodontic treatment.

This case report with literature review describes 2 cases of immature teeth with pulp necrosis and periapical disease secondary to dens evaginatus treated with regenerative endodontic procedures (REPs). The primary outcome was root development after REPs, with secondary outcomes including root morphology. Follow-up was 4 years.

Both cases showed uncommon root developments, including root curvature and segmental root formation. The authors note that even clinically successful REPs may result in unusual root morphology, especially in cases with pre-existing inflammation or concurrent orthodontic treatments. The literature review suggests an association between these factors and unusual root morphology.

Limitations include a small sample size of only 2 cases. The certainty of the evidence is low, based on these case reports. The study does not establish a definitive causal link for all cases of abnormal root formation but identifies potential contributing factors.

Practice relevance: Clinicians should be aware that unusual root morphology can occur after REPs, particularly in the presence of pre-existing inflammation or orthodontic treatment. This information can guide patient counseling and treatment planning.

When a young person's tooth becomes infected or damaged, doctors often use regenerative endodontic procedures (REPs) to try and save the tooth. These treatments aim to help the tooth continue to develop even after the inner pulp has died. It is a vital tool for preserving healthy smiles in children and teenagers.

A recent look at two specific cases involving a condition called dens evaginatus showed that these procedures can work, but they might come with surprises. In both cases, the patients had immature teeth with infections. While the treatments were successful in saving the teeth, the roots grew in unusual ways, including curving or forming segments.

Because this report only looked at two cases, we cannot say for certain how common these changes are. However, it highlights that factors like existing inflammation or ongoing orthodontic work might influence how a tooth heals. It serves as a reminder for doctors to monitor root shapes closely during and after treatment.

What this means for you:
Regenerative treatments can save damaged teeth but may lead to unusual root shapes in some cases.

Common questions

What is a regenerative endodontic procedure?

These are treatments used for immature teeth where the inner pulp has died. The goal is to save the tooth and allow it to continue growing its root. In this specific report, these procedures were used on two cases of teeth with infections caused by a condition called dens evaginatus.

Can these treatments cause changes to the shape of the tooth?

Yes, it is possible. The study found that even when the treatment was successful, the roots grew in unusual ways, such as curving or forming segments. These types of changes can happen especially if there is pre-existing inflammation or if the patient is undergoing orthodontic treatment at the same time.

Is this a common problem for patients?

Because this report only looked at two cases, it is hard to say how often these unusual root shapes happen. The evidence is currently limited, but it warns doctors to be aware that successful treatments can still result in unexpected root growth patterns.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Regenerative endodontic procedures (REPs) promote continued root development in immature teeth with pulp necrosis. However, endodontic infection or physical trauma during tooth development may lead to abnormal root formation. This report describes two cases of immature teeth with periapical disease secondary to dens evaginatus, both treated with REPs and followed up for 4 years. Uncommon root developments, including root curvature and segmental root formation, were observed. A review of the relevant literature was conducted to identify the potential contributing factors. Clinicians should be aware that even clinically successful REPs may result in unusual root morphology, especially in cases with pre-existing inflammation or concurrent orthodontic treatments.
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