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HPV16 constitutes 92.5% of single infections in oropharyngeal squamous cell carcinoma casesHPV16 Remains the Most Common Type in Throat Cancer

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Key Takeaway
Note that HPV16 is the predominant genotype in 92.5% of single infections in oropharyngeal squamous cell carcinoma.

This meta-analysis synthesized data from 183 studies involving 17,443 patients with biopsy-confirmed oropharyngeal squamous cell carcinoma (OPSCC) where HPV was detected by molecular methods. The analysis focused on the global prevalence, genotype distribution, and temporal trends of HPV in these patients across 35 countries.

The primary finding is that HPV16 is the predominant genotype for single infections, accounting for 92.5% of cases. Other single HPV genotypes identified include HPV33 (3.3%), HPV18 (2.8%), and HPV35 (2.8%). Coinfections were reported as rare, occurring in 1.3% of cases, most frequently involving HPV16 with other high-risk genotypes such as HPV18, 33, and 31. Regarding temporal trends, the analysis noted a decline in HPV16 concurrent with a rise in non-HPV16 genotypes.

These findings underscore the importance of HPV genotyping to support surveillance and vaccination strategies and to improve the understanding of HPV-driven OPSCC tumor biology. While the study identifies a temporal trend, specific years or rates for the decline or rise were not reported. The results provide a broad overview of the global landscape of HPV in OPSCC.

How this fits prior evidence

This meta-analysis reinforces the existing evidence that HPV shows a strong association with oropharyngeal SCC. It provides specific data on the prevalence of HPV16, which constitutes 92.5% of single infections, and identifies other common genotypes like HPV18, 33, and 35. The finding of a rise in non-HPV16 genotypes may inform the transition toward a multidimensional, adaptive treatment model for HPV-associated OPSCC by highlighting the evolving landscape of viral drivers.

Researchers analyzed data from 183 different studies involving over 17,000 patients with a specific type of throat cancer called oropharyngeal squamous cell carcinoma. The study looked at the different types of human papillomavirus (HPV) that cause these tumors across 35 different countries.

The results show that HPV16 is the most common type found, appearing in 92.5% of the cases. Other types, such as HPV33, HPV18, and HPV35, were found much less frequently. The study also noted that cases where a patient had more than one type of HPV at the same time were rare, occurring in only about 1.3% of cases.

While the data shows a trend where HPV16 is decreasing and other types are increasing, the study does not provide specific dates or rates for these changes. These findings help doctors better understand how these viruses behave. This information is important for improving how doctors monitor the disease and how they plan for future vaccination strategies.

What this means for you:
HPV16 is the most common virus type linked to this throat cancer, making it a key focus for tracking and prevention.

Common questions

What is the most common type of HPV found in these cases?

The study found that HPV16 is the most common type, appearing in 92.5% of the cases. Other types like HPV33, HPV18, and HPV35 were much less common, each appearing in less than 3.3% of the cases. This confirms that HPV16 is the primary genotype associated with this specific throat cancer.

Are cases of multiple HPV infections common?

No, cases where a patient has more than one type of HPV at the same time are rare. The study found these coinfections occurred in only 1.3% of the cases. When they did occur, they most frequently involved HPV16 along with other high-risk types like HPV18, 33, or 31.

How do these findings help with cancer prevention?

By identifying the specific types of HPV that cause these tumors, doctors can better understand the biology of the cancer. These findings help health officials improve surveillance and create better vaccination strategies to protect people from the most common high-risk strains like HPV16.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
PURPOSE: This study systematically reviewed and meta-analyzed the global prevalence and genotype distribution of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC). MATERIALS AND METHODS: Six databases and gray literature were searched and identified studies of biopsy-confirmed OPSCC with HPV detected by molecular methods. A meta-analysis was performed using random-effects generalized linear mixed models to calculate pooled prevalence estimates with 95% confidence intervals. Temporal trends were explored by meta-regression, and risk of bias was assessed using Joanna Briggs Institute tools. RESULTS: A total of 183 studies with 34,627 OPSCC patients from 35 countries were included; of these, 17,443 were HPV-positive with available genotyping data. The meta-analysis showed that HPV16 was the predominant genotype (92.5% of single infections), followed by HPV33 (3.3%), HPV18 (2.8%), and HPV35 (2.8%). Coinfections were rare (1.3%), most frequently involving HPV16 with other high-risk genotypes such as HPV18, 33, and 31. Meta-regression revealed a temporal decline in HPV16 concurrent with a rise in non-HPV16 genotypes. CONCLUSION: HPV16 remains the predominant genotype in OPSCC worldwide, the contribution of other oncogenic types is increasing. These findings reinforce the importance of HPV genotyping to support surveillance and vaccination strategies and to improve understanding of HPV-driven OPSCC tumor biology.
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