Narrative review examines carbapenem-resistant E. coli and One Health approach in AMR governance

This publication is a narrative review focusing on carbapenem-resistant Escherichia coli (CREC) and its role in antimicrobial resistance (AMR) governance. The review synthesizes existing literature to discuss the challenges posed by CREC, without reporting specific study populations, interventions, comparators, or outcomes from primary trials. Its scope includes theoretical and policy-oriented aspects of managing this resistant pathogen.

The key arguments synthesized by the authors center on the integration of a One Health approach in AMR governance. They highlight how understanding CREC can inform evidence-based public health policy and support anti-infective clinical practice theoretically. The review does not provide pooled effect sizes, p-values, or confidence intervals, as it is not a meta-analysis or primary study, but rather a qualitative discussion of existing knowledge.

Limitations are not explicitly detailed in the source, but as a narrative review, it may lack systematic methods for literature selection and synthesis, potentially introducing bias. The authors do not report funding or conflicts of interest. In terms of practice relevance, the review offers theoretical support for clinical practice and public health policy, facilitating the implementation of the One Health approach in AMR governance, but clinicians should rely on direct evidence from trials for specific interventions.