Narrative review offers theoretical guidance for early prevention, treatment, and prognosis of hepatocellular carcinoma.
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Key Takeaway
Note that this narrative review offers theoretical guidance for hepatocellular carcinoma management without reported specific data.
The source is a narrative review focused on hepatocellular carcinoma. It aims to provide systematic theoretical guidance for early prevention, precise treatment, and prognosis improvement of the disease. The authors do not report specific study populations, interventions, comparators, or adverse events, as these details were not reported in the input data. Consequently, the review functions primarily as a conceptual framework rather than a quantitative analysis of clinical trial data.
The scope of the review covers the broad management of hepatocellular carcinoma, emphasizing the need for integrated approaches to care. Because the input data did not include specific medications, sample sizes, or follow-up durations, the text cannot quantify treatment effects or safety profiles. The review relies on existing literature to construct a theoretical basis for clinical practice rather than presenting new empirical evidence.
Limitations acknowledged by the authors include the lack of reported specific data points, which prevents a detailed assessment of efficacy or tolerability. The review does not provide pooled effect sizes or confidence intervals, as these metrics were not reported in the source material. Practice relevance is framed as providing guidance for prevention and treatment strategies, though the specific applicability to individual patient scenarios remains theoretical without reported outcome data.
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View Original Abstract ↓
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide, with chronic liver inflammation as the core driver of its initiation and progression. Regardless of etiology, HCC development follows the classic progressive pathway of “chronic inflammation - liver fibrosis - cirrhosis - liver cancer”. In this review, we propose an innovative “Single Wick, Dual Interwoven Strands” regulatory framework to systematically delineate the role of inflammation in the entire continuum of HCC progression. We define chronic liver inflammation as the “Wick” – the core driver that initiates and sustains the pro-tumor cascade, while inflammatory cells and inflammatory cytokines act as the two interwoven functional “Strands” that execute the pro-carcinogenic effects of inflammation via a tightly regulated interactive network. Their synergistic crosstalk drives five core terminal biological outcomes of HCC progression: invasion and metastasis, angiogenesis, immune escape, metabolic reprogramming, and therapeutic resistance. Based on this framework, we dissect the core mechanisms of inflammation-driven HCC, summarize the latest advances in inflammation-targeted diagnostic, therapeutic and preventive strategies, and highlight the clinical translational prospects of this framework. This work provides systematic theoretical guidance for early prevention, precise treatment and prognosis improvement of HCC.
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