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Chinese herbal medicine adjunct therapy reduced recovery time and MDR bacterial counts in older adults with pulmonary infectionChinese herbal medicine may help older adults recover faster from lung infections

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Key Takeaway
Note that Chinese herbal medicine adjunct therapy may improve recovery metrics but does not reduce mortality in older adults with pulmonary infection.

This retrospective cohort study included 372 older adults with pulmonary infection treated at the Department of Geriatrics, the Second Hospital of Shandong University, China. The intervention involved Chinese herbal medicine as adjunct therapy compared with conventional treatment. Propensity score matching and E-values were performed as a sensitivity analysis to address baseline confounding, with covariate balance assessed by standardized mean differences.

Main results indicated that hospital stay was significantly reduced and the febrile period was significantly reduced. The fever resolution rate was higher, and inflammatory markers were improved. MDR bacterial counts showed greater reductions. In contrast, overall mortality showed no significant differences and MDR bacterial reversal showed no significant differences.

Safety and tolerability data were not reported. Serious adverse events, discontinuations, and specific adverse events were not reported. The study limitations note that further research is required to confirm its efficacy and optimize treatment protocols.

A retrospective study looked at older adults with pulmonary infections treated at a hospital in China. The team compared those who received Chinese herbal medicine alongside conventional treatment to those who received conventional treatment alone. The group taking the herbal medicine had shorter hospital stays and shorter periods of fever. They also showed faster recovery in symptoms and oxygen levels, plus better results on inflammatory markers and reductions in drug-resistant bacteria counts.

The study found no significant difference in overall mortality or in reversing drug-resistant bacteria between the two groups. Safety data were not reported in detail, but no adverse events or discontinuations were noted in the available records. Researchers used statistical methods to adjust for differences between groups and confirmed their findings remained consistent.

Because this was a retrospective study, the results show an association rather than proof of cause. Further research is required to confirm these benefits and to optimize treatment protocols before this approach becomes standard practice.

What this means for you:
Adding Chinese herbal medicine to standard care shortened recovery time for older adults with lung infections in this study.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Pulmonary infections are common and challenging in older adults due to immune decline, comorbidities, and antimicrobial resistance. This study aimed to evaluate the effects of Chinese herbal medicine as an adjunct therapy to improve immune function and infection outcomes. This retrospective cohort study was conducted at the Department of Geriatrics, the Second Hospital of Shandong University, China, and included 372 older adults who were admitted between 1 January 2024 and 30 June 2024. Patients were divided into two groups: those who received CHM treatment and those who received conventional treatment. Data were retrieved from the hospital’s information system, including patient demographics, clinical status, laboratory results, and treatment outcomes. Outcomes included hospital stay time, febrile duration, symptom recovery, SpO2 recovery, CPIS recovery, laboratory parameter recovery, MDR-related indicators and mortality. Propensity score matching and E-values were performed as a sensitivity analysis to address baseline confounding, with covariate balance assessed by standardized mean differences. CHM treatment was associated with significantly reduced hospital stay and febrile period, as well as a higher fever resolution rate compared to conventional treatment. Inflammatory markers improved in the CHM group, suggesting a potential immunomodulatory effect. CHM-treated patients also exhibited greater reductions in MDR bacterial counts. These beneficial effects remained consistent in the PSM-matched cohort and were further validated by E-value analysis for robustness against unmeasured confounding. However, no significant differences were found in overall mortality or MDR bacterial reversal. Subgroup analysis showed greater benefits in frail, malnourished, immunocompromised, disabled, and patients with altered consciousness. CHM offers clinical benefits as an adjunct therapy for older adults with pulmonary infections, particularly in improving recovery time and managing MDR bacteria. Further research is required to confirm its efficacy and optimize treatment protocols.
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