Hungarian app use associated with lower reported antibiotic, antipyretic, and doctor visit use in children.

In conventional mainstream practice there is a prevailing negative attitude towards fever, which persists despite the evidence of beneficial immunological effects and lack of practical implementation of this knowledge into the healthcare system. Integrative approaches represent an added value in promoting behavioral change towards supportive fever management. We examined associations between use of the FeverFriend® app and caregiver-reported antibiotic and antipyretic use and healthcare utilization for febrile illnesses in children. Prospective patient registry within a mobile app, including a decision aid, connected with a knowledge base. Recruitment and data collection were conducted continuously throughout the study period from 01 December 2020 to 1 September 2025. In this publication we evaluate Hungarian users’ data. The study population ranged from otherwise healthy individuals to patients with chronic diseases, aged between 0 and 18 years. There were no pre-specified groups or subgroups assigned to receive specific intervention(s) (or no intervention) based on the study protocol. In total, 24,371 caregivers registered 26,042 children. Caregivers recorded 17,994 illness episodes and 31,874 temperature measurements; 7,377 episodes included a completed end-of-illness review. Paired analyses were based on children with both baseline and reviewed-episode data. Caregiver-reported antibiotic use, antipyretic use, and doctor consultation were lower in the reviewed episode than in baseline recall (McNemar test with continuity correction, all p  FeverFriend registry data are consistent with an association between app use and lower episode-level reporting of antibiotics, antipyretics, and doctor visits compared with 12-month baseline recall.