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Retrospective study finds variation in COPD exacerbation care between respiratory and internal medicine

Retrospective study finds variation in COPD exacerbation care between respiratory and internal medic…
Photo by Annie Spratt / Unsplash
Key Takeaway
Note variation in COPD exacerbation care between specialties may reflect patient mix, not quality.

A retrospective cohort study analyzed 6,277 hospital admissions for COPD exacerbations in adults aged 40 years or older between January 2017 and March 2025. The study compared patients admitted under respiratory medicine (RM, 51.2% or 3,211 admissions) with those admitted under internal medicine (IM, 48.8% or 3,066 admissions). Patients admitted directly to ICUs or with asthma or bronchiectasis were excluded.

The primary outcome was variation in investigations and treatment practices. The study observed variation between RM and IM admissions, though specific practices and effect sizes were not reported. Secondary analysis using multivariable logistic regression identified clinical characteristics associated with RM admission: RM patients were younger (mean 73.2 ± 10.7 years vs. 75.6 ± 10.8 years for IM, p < 0.001) and had fewer comorbidities (p < 0.001).

Safety and tolerability data were not reported. Key limitations include the retrospective, observational design, which precludes causal inference. The authors note differences likely reflect variation in patient characteristics, illness severity, and clinical workflows rather than differences in quality of care attributable to specialty alone. For practice, this evidence highlights systematic variation in care pathways but cannot determine if one specialty's approach is superior.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Chronic obstructive pulmonary disease (COPD) exacerbations are a major cause of hospitalization and healthcare utilization. The impact of inpatient specialty allocation on management practices remains unclear. This study examined variation in investigations and treatment practices among COPD patients admitted under respiratory medicine (RM) compared with internal medicine (IM), and evaluated clinical characteristics associated with RM admission. We conducted a retrospective cohort study of adults aged ≥40 years admitted for COPD exacerbations between January 2017 and March 2025. Patients were identified using ICD-10 COPD codes, excluding those admitted directly to ICUs or with asthma or bronchiectasis. Demographics, comorbidities, investigations, treatments, and hospitalization outcomes were analyzed. The primary outcome was variation in investigations and treatment practices between RM and IM admissions. The secondary outcome was identification of clinical characteristics associated with RM admission using multivariable logistic regression. Among 6,277 COPD admissions, 3,211 (51.2%) were under RM and 3,066 (48.8%) under IM. Patients admitted under RM were younger (73.2 ± 10.7 vs. 75.6 ± 10.8 years, p  Variation in investigations and treatment practices was observed between RM and IM admissions for COPD exacerbations. These differences likely reflect variation in patient characteristics, illness severity, and clinical workflows rather than differences in quality of care attributable to specialty alone.
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