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Music intervention significantly improves GCS scores and awakening rates in patients with disorders of consciousnessMusic Intervention May Improve Awareness in Patients with Consciousness Disorders

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Key Takeaway
Consider music intervention as a safe, non-invasive adjunctive measure to improve consciousness outcomes in DOC patients.

This meta-analysis synthesized data from 12 randomized controlled trials involving 926 patients with disorders of consciousness (DOC) to evaluate the impact of music interventions on recovery outcomes. The analysis focused on primary outcomes including GCS scores and awakening rates, alongside secondary measures such as CRS-R and NIHSS scores.

Key findings indicate that the music intervention group achieved significantly higher GCS scores compared to control groups (MD = 2.32). Furthermore, patients in the music group were more likely to achieve a GCS score of > 8 (OR = 5.98) and showed a significantly superior awakening rate (OR = 3.76). Secondary outcomes also favored the intervention, with higher CRS-R scores (MD = 2.86) and lower NIHSS scores (MD = -1.24) in the music group.

The authors note that more high-quality randomized controlled trials are needed to further verify the specific effects and mechanisms of these interventions. Clinical application suggests music may be a safe, non-invasive adjunctive measure for improving consciousness levels in rehabilitation nursing care.

How this fits prior evidence

This meta-analysis confirms prior findings that music interventions show significant improvement in patients with disorders of consciousness. It specifically quantifies the magnitude of improvement in GCS scores (MD = 2.32) and awakening rates (OR = 3.76), extending the previous observation that such interventions may improve consciousness levels.

A large review of 12 randomized controlled trials involving 926 patients looked at how music affects those with disorders of consciousness. The study compared patients who received music interventions against a control group to see if it helped their recovery levels.

The results showed that the music group had significantly higher scores on several scales used to measure awareness and alertness. Specifically, these patients were more likely to reach certain awakening milestones and showed better scores on the Coma Recovery Scale-Revised. They also showed lower scores on a scale measuring stroke severity.

While the findings are promising, this was a meta-analysis of existing trials. The researchers noted that more high-quality studies are needed to fully understand how music works and its specific effects. For now, it may be a safe and non-invasive way to support rehabilitation care for patients with these conditions.

What this means for you:
Music intervention is linked to better consciousness scores and awakening rates in some patients.

Common questions

Can music help patients who are unconscious?

The study found that patients receiving a music intervention had significantly higher scores on scales used to measure consciousness. These patients were also much more likely to reach certain awakening milestones compared to those who did not receive music therapy.

What specific improvements were seen in the study?

Patients in the music group showed higher scores on the Coma Recovery Scale-Revised and better overall consciousness scores. They also had lower scores on the National Institutes of Health Stroke Scale, which suggests a link to improved outcomes.

Is music therapy safe for these patients?

The study suggests that music may serve as a safe and non-invasive way to support nursing care. However, more high-quality trials are still needed to fully understand the exact mechanisms of how it works.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
ObjectiveThe study aimed to systematically evaluate the effects of music intervention on outcomes related to the recovery of consciousness in patients with disorders of consciousness (DOC).MethodsDatabases including PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), and ProQuest were systematically searched from January 1970 to December 2025 to identify relevant randomized controlled trials (RCTs). The literature was screened based on pre-established inclusion and exclusion criteria, and the review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of the included studies was assessed using the Cochrane Risk of Bias tool (RoB 1).ResultsA total of 12 randomized controlled trials (RCTs) involving 926 patients with disorders of consciousness (DOC) were included. As the types of outcome indicators reported in the included studies varied, the number of studies included for each outcome also differed. Specifically, five studies were included in the analyses of Glasgow Coma Scale (GCS) scores and the GCS-based awakening rate, whereas two studies were included in the analyses of GCS scores of > 8, the Coma Recovery Scale-Revised (CRS-R), and the National Institutes of Health Stroke Scale (NIHSS). A meta-analysis showed that GCS scores were significantly higher in the music intervention group than in the control group (mean difference (MD) = 2.32). The analyses of GCS scores of > 8 showed that a higher proportion of patients in the music intervention group achieved a GCS score of > 8 (odds ratio (OR) = 5.98). The awakening rate also indicated that the music intervention group was significantly superior to the control group (OR = 3.76). For secondary outcomes, the music intervention group showed higher CRS-R scores (MD = 2.86) and lower NIHSS scores (MD = −1.24).ConclusionMusic intervention may help improve consciousness levels and awakening-related outcomes in patients with disorders of consciousness and may serve as a safe and non-invasive adjunctive measure in rehabilitation nursing care. However, more high-quality randomized controlled trials are needed to further verify its effects and mechanisms.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420261354569, Identifier: CRD420261354569.
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