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JUST Score variables predict hemorrhagic versus ischemic stroke differentiation in EMS-transported patients.

JUST Score variables predict hemorrhagic versus ischemic stroke differentiation in EMS-transported p…
Photo by Alexander Grey / Unsplash
Key Takeaway
Consider using JUST Score variables and clinical signs like altered mental status to aid hemorrhagic versus ischemic stroke differentiation in prehospital settings.

This review examined a North American cohort of adult patients with either ischemic or hemorrhagic stroke transported by emergency medical services. The analysis focused on differentiating between the two stroke types using specific clinical variables. The primary exposure included the JUST-7 Score, full JUST Score variables, and a modified version incorporating sex, numbness, comorbidities, and AHA guidelines. The comparator was the distinction between hemorrhagic and ischemic strokes.

The area under the curve (AUC) for the JUST and JUST-7 variables was 0.70 and 0.68, respectively. When sex, numbness, comorbidities, and AHA guidelines were added, the AUC improved to 0.72. These metrics indicate the predictive performance of the scoring systems in distinguishing stroke etiology.

Specific clinical features were associated with increased odds of hemorrhagic stroke. Altered mental status showed an odds ratio of 1.88 (95% CI 1.47–2.39). Headache was associated with an odds ratio of 1.82 (95% CI 1.31–2.53). Systolic blood pressure ≥165mmHg yielded an odds ratio of 2.32 (95% CI 1.82–2.94). Nausea and vomiting demonstrated the highest association with an odds ratio of 2.90 (95% CI 2.09–4.02).

Safety data, adverse events, and discontinuations were not reported in this review. A key limitation noted is that more research is needed to develop a robust tool that can be widely applied and help EMS clinicians select the best receiving hospital for their patients. These results may help EMS differentiate between ischemic and hemorrhagic strokes, but the evidence remains observational and requires validation.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Ischemic and hemorrhagic strokes require different treatments which are not available at all receiving hospitals. Prehospital differentiation of these types of strokes can help optimize patient transport to the appropriate facility. The Japan Urgent Stroke Triage – 7 (JUST-7) Score has been used to help differentiate between stroke types. The objective of this study was to reconstruct a stroke screening scale that could differentiate between ischemic and hemorrhagic strokes in a North American population using the variables in the JUST and JUST-7 scores. This two-state cohort of acute strokes transported by emergency medical services (EMS) included adult patients with either an ischemic or hemorrhagic stroke. Logistic regression models compared hemorrhagic to ischemic strokes using the following sets of explanatory variables: (1) the JUST-7 Score, (2) the full JUST Score variables, and (3) JUST plus sex, numbness, comorbidities, and AHA guidelines. Extraneous covariates in the full model were eliminated using backwards elimination, alpha = 0.10. The predictive power of the model was assessed with receiver operating characteristic (ROC) curves and area under the curve (AUC). AUC was compared between the full model and the model selected by backwards elimination. The AUC for the JUST and JUST-7 variables was 0.70 and 0.68, respectively. The AUC for JUST plus sex, numbness, comorbidities, and AHA guidelines was 0.72. When comparing neurological symptoms, patients were more likely to be diagnosed with hemorrhagic stroke when they presented with altered mental status (OR 1.88, 95% CI 1.47–2.39), headache (OR 1.82, 95% CI 1.31–2.53), systolic blood pressure ≥165mmHg (OR 2.32, 95% CI 1.82–2.94), or nausea and vomiting (OR 2.90, 95% CI 2.09–4.02). In a North American population, the JUST-7 variables had moderate predictive power for differentiating between ischemic and hemorrhagic strokes. Patients with an elevated blood pressure, altered mental status, headache, or nausea and vomiting had greater odds of having a hemorrhagic stroke. These results may help EMS differentiate between ischemic and hemorrhagic strokes, but more research is needed to develop a robust tool that can be widely applied and help EMS clinicians select the best receiving hospital for their patients.
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