Systematic review finds CAEP latencies and amplitudes correlate with speech perception in noise
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Key Takeaway
Consider CAEP latencies/amplitudes as potential research correlates of speech-in-noise perception, pending protocol standardization.
This systematic review examined the relationship between non-task related cortical auditory evoked potentials (CAEPs) and speech perception in noise (SPiN) outcomes in adults with normal hearing (n=204), sensorineural hearing loss (n=238), or cochlear implants. The analysis, which could not conduct a meta-analysis due to methodological heterogeneity, identified that N1 latency, P2 latency, and N1-P2 amplitude of the onset CAEP and the acoustic change complex (ACC) were most consistently correlated with SPiN performance, particularly in sentence-based tests. In contrast, mismatch negativity (MMN) showed limited predictive value, which varied by age and hearing status.
Safety and tolerability data were not reported in the review. The authors note that CAEPs show promise as electrophysiological indicators for populations where behavioral testing can be unreliable, such as cochlear implant users or individuals with cognitive or language barriers.
Key limitations include significant methodological heterogeneity across studies, which prevented quantitative synthesis, and a lack of standardized protocols. The authors emphasize the need for further longitudinal research to validate the application of these measures in clinical settings. Funding sources and author conflicts of interest were not reported.
For practice, this review suggests that specific CAEP components may serve as objective correlates of speech-in-noise perception. However, clinicians should interpret these findings cautiously, as the evidence is currently observational and correlational, with no established causal link. The variability in MMN findings and the need for standardized protocols mean these measures are not yet ready for routine clinical application.
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View Original Abstract ↓
IntroductionSpeech perception in noise (SPiN) is a critical challenge for individuals with sensorineural hearing loss (SNHL), and current behavioral assessments can be unreliable in populations with language barriers or cognitive impairment. Cortical auditory evoked potentials (CAEPs) can serve as a supplementary measurement as they often show strong correlations with SPiN outcomes across diverse hearing profiles.MethodsFollowing PRISMA and SWiM guidelines, this systematic review includes studies from PubMed, Web of Science, and Scopus databases that examined the relationship between non-task related CAEPs and SPiN outcomes in adults with normal hearing, SNHL, or cochlear implants.ResultsSixteen studies were included, encompassing 238 participants with SNHL and 204 participants with normal hearing. Across studies, N1 latency, P2 latency, and N1-P2 amplitude of the onset CAEP and acoustic change complex (ACC) are most consistently correlated with SPiN performance, particularly in sentence-based tests. The mismatch negativity (MMN) showed limited predictive value, as findings varied by age and hearing status. A meta-analysis was not conducted due to methodological heterogeneity.ConclusionOnset CAEP and ACC N1 and P2 latencies together with N1-P2 amplitudes particularly demonstrate potential as electrophysiological indicators of SPiN performance. Their clinical utility is promising for populations where behavioral testing can be unreliable, such as CI users or individuals with cognitive or language barriers. However, standardization of protocols and further longitudinal research are needed to validate their application in clinical settings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023404158, identifier PROSPERO (CRD42023404158).
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