Prospective cohort study links age, GCS, and CT scores to posttraumatic confusional state duration in TBI patients.
This prospective inception cohort study included 424 surviving neurosurgical patients with moderate or severe traumatic brain injury (TBI), focusing on the duration of the posttraumatic confusional state (PTCS) as the primary outcome. The study did not report specific interventions, comparators, follow-up duration, or safety data, limiting the ability to assess causality or tolerability.
Main results showed that PTCS duration ≤7 days was associated with lower age, higher Glasgow Coma Scale (GCS) scores, lower Rotterdam CT scores, and absence of road traffic accidents, with p-values <0.001 for age and GCS, 0.004–0.002 for CT scores, and 0.006 for road traffic accidents; 58% of patients in the moderate TBI group had this shorter duration. Conversely, PTCS duration >28 days was associated with higher age, lower GCS scores, and higher Rotterdam CT scores, with p-values <0.001 for all; 52% of patients in the severe TBI group experienced this longer duration. Proxies of brain reserve were not independently associated with PTCS duration, though effect sizes and absolute numbers were not reported.
Key limitations include the observational design, which precludes causal inferences, and lack of reported data on interventions, follow-up, safety, funding, or practice relevance. The findings suggest that age, GCS scores, and CT imaging results may be useful prognostic indicators for PTCS duration in moderate to severe TBI patients, but clinicians should interpret these associations cautiously due to the study's constraints and absence of intervention-based evidence.
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