This single-blinded randomized controlled trial enrolled 34 voluntary patients with chronic hemiplegia (>6 months post-stroke), aged 45-65 years, with MMSE scores >24 and spasticity graded 1 or 1+ on the Modified Ashworth Scale. Patients were randomized to receive either 60 minutes of conventional physical therapy (CPT) plus 120 minutes of patient-tailored modified constraint-induced movement therapy (mCIMT) with trunk restraint (TR), or CPT alone, three sessions per week for six consecutive weeks.
All outcome measures, including the Wolf Motor Function Test (WMFT), Berg Balance Scale (BBS), and Stroke Specific Quality of Life Scale (SS-QOL), showed significant improvements from baseline to post-intervention in both groups (p<0.01). The experimental group exhibited significantly greater gains in SS-QOL scores compared to the control group (p<0.005).
Adverse events, serious adverse events, discontinuations, and tolerability were not reported. The study did not report any limitations, funding sources, or conflicts of interest.
Clinicians should interpret these findings cautiously given the small sample size and lack of reported safety data. The combination of mCIMT with trunk restraint may offer additional benefits for chronic stroke patients, but further research is needed to confirm these results and establish long-term outcomes.
View Original Abstract ↓
BackgroundThe upper extremity functional recovery remains a major challenge for specialists during post stroke rehabilitation, pertaining to adoption of various compensatory strategies by patients leading to motor redundancy and persistent functional limitations.ObjectivesThe study aimed to evaluate the effectiveness of Patient Tailored-Modified Constraint Induced Movement Therapy (mCIMT) combined with Trunk Restraint (TR) on Upper Extremity motor ability, balance, and health-related quality of life (HR-QOL) in chronic stroke survivors.MethodsIn this patient-blinded trial, 34 voluntary patients with chronic hemiplegia (>6 months post-stroke), aged 45-65 years, with Mini-Mental State Examination (MMSE) scores > 24 having and spasticity graded 1 or 1 + on Modified Ashworth Scale (MAS), were recruited and randomly allocated (1:1) to experimental or control groups. The experimental group received 60 min of Conventional Physical Therapy (CPT) plus 120 min of mCIMT with TR, while the control group received CPT treatment alone, three sessions per week for six consecutive weeks. Outcomes were assessed pre- and post-intervention using the Wolf Motor Function Test (WMFT), Berg Balance Scale (BBS), and Stroke Specific Quality of Life Scale (SS-QOL).ResultsBoth groups demonstrated significant improvements from baseline to post-intervention ( < 0.01) across all outcome measures. However, the experimental group exhibited significantly greater gains in functional ability, as reflected by SS-QOL scores ( < 0.005), compared to the control group.ConclusionEighteen sessions of mCIMT along with TR, delivered over six weeks in combination with CPT, demonstrated significant improvements in all outcomes (WMFT, BBS, and SS-QOL) among chronic stroke patients and is as beneficial to individual rehabilitation as conventional therapy alone. ClinicalTrails.gov (Registration ID: NCT06692569).