Systematic review identifies ferroptosis as a key mechanism in acquired sensorineural hearing loss

This systematic review explores the molecular pathways of ferroptosis and the progress of ferroptosis-targeted interventions in the context of sensorineural hearing loss. The scope includes drug-induced, noise-induced, and age-related hearing loss. The authors identify ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, as a key mechanism in acquired sensorineural hearing loss.

The review synthesizes advancements in interventions designed to target this cell death pathway. While the potential for otoprotective therapies is noted, the authors emphasize that the discussed interventions are currently limited to preclinical models. The transition from laboratory findings to clinical application is not yet established.

Significant gaps remain in the current literature, as the authors note that targeting ferroptosis is still largely preclinical. Future clinical translation will likely require the integration of novel technologies, such as single-cell omics and nano-delivery systems. Clinicians should interpret these findings as early-stage mechanistic insights rather than established therapeutic options.