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Delayed presentation and comorbidities increase total annual acute stroke care costs in Addis Ababa.

Delayed presentation and comorbidities increase total annual acute stroke care costs in Addis Ababa.
Photo by Joshua Chehov / Unsplash
Key Takeaway
Note that delayed presentation and comorbidities are associated with higher annual stroke care costs in this Ethiopian cohort.

This prospective, cross-sectional cost-of-illness study assessed the total cost of acute stroke care per patient per year among 99 survivors admitted to two specialized hospitals in Addis Ababa, Ethiopia. The analysis included direct and indirect costs as secondary outcomes, with data collected over a one-year follow-up period. No adverse events, serious adverse events, discontinuations, or tolerability data were reported, as these metrics are not applicable to a cost-of-illness study design.

The median total cost of acute stroke care per patient per year was $286. Direct costs accounted for $193.77 of this total, while indirect costs were $74. Adjusted cost ratios indicated that delayed hospital presentation (arrival >4.5 h after symptom onset) was associated with a ratio of 1.78. ICU admission corresponded to an adjusted cost ratio of 1.56. Older age and the presence of at least one comorbid condition each yielded an adjusted cost ratio of 1.27. Rural residence was associated with an adjusted cost ratio of 1.40.

The study design limits the ability to establish causal relationships between patient characteristics and increased costs. Additionally, the sample size of 99 patients from a single region may limit the generalizability of these cost estimates to other settings. Understanding the cost of stroke in Ethiopia is critical for planning the implementation of acute care services, including stroke treatments, under universal health coverage, ensuring that all stroke patients benefit.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedMar 2026
View Original Abstract ↓
BackgroundThe cost of acute stroke data is scarce in developing countries, especially Ethiopia, despite its significance for public health. This study aimed to assess the total cost of acute stroke care per patient per year among acute stroke patients admitted to tertiary hospitals in Addis Ababa, Ethiopia.MethodsAn incidence-based, prospective, cross-sectional cost-of-illness study was conducted among 99 acute stroke survivors admitted to two specialized hospitals in Addis Ababa. A micro-costing technique was applied to pinpoint cost-generating elements and assign the proper unit costs for the two cost categories, direct and indirect. A multivariable generalized linear model was employed to identify predictors of acute-phase costs among stroke patients.ResultsThe median cost of acute stroke care per patient per year was $286, with direct and indirect costs of $193.77 and $74, respectively. Between-group cost differences were primarily driven by delayed hospital presentation (arrival >4.5 h after symptom onset; adjusted cost ratio [CR] 1.78), ICU admission (CR 1.56), older age (CR 1.27), at least one comorbid condition (CR 1.27), and rural residence (CR 1.40).ConclusionThe costs of acute stroke care in public tertiary hospitals in Ethiopia are very high, with over 30% of GDP per capita spent on acute stroke care. Understanding the cost of stroke in Ethiopia is critical for planning the implementation of acute care services, including stroke treatments, under universal health coverage, ensuring that all stroke patients benefit.
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