Case report describes neurologic complications in two US patients with monkeypox

A case report describes two patients in Colorado and the District of Columbia, United States, who developed neurologic complications associated with monkeypox infection. The report documents 2 cases of these complications. No comparator group, specific neurologic outcomes, effect sizes, or statistical measures were reported.

Safety and tolerability data, including adverse events, serious adverse events, and discontinuations, were not reported for these patients. The follow-up duration was also not specified.

Key limitations include the inherent nature of a case report, which cannot establish causality, frequency, or risk. The sample size is only 2 patients, and no data on the broader population or clinical course is provided. Funding sources and author conflicts of interest were not reported.

For practice, this report suggests clinicians should be aware that neurologic complications can occur in patients with monkeypox. However, this evidence is extremely preliminary and cannot inform estimates of incidence, risk factors, or prognosis. The clinical relevance and appropriate management of such complications remain undefined.