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Narrative review synthesizes neural activation patterns in the caudate nucleus and dorsal striatum during gustatory stimulation

Narrative review synthesizes neural activation patterns in the caudate nucleus and dorsal striatum…
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Key Takeaway
Note that experimental designs are frequently heterogeneous and more evidence is needed to elucidate the link between taste and subcortical regions.

This narrative review synthesizes current understanding of neural activation patterns within the caudate nucleus and dorsal striatum during gustatory stimulation. The scope covers responses to different metabolic states, motivation, and hedonic value. The authors report that these regions show consistent activation during such stimulation.

The review further describes interactions between these subcortical regions and areas involved in reward and emotional processing. These interactions occur across both healthy individuals and those with disease. The authors do not provide specific effect sizes or absolute numbers for these observations.

The authors acknowledge significant limitations, noting that experimental designs are frequently heterogeneous. They state that more evidence is needed to elucidate the link between taste and these subcortical regions. Funding or conflicts of interest were not reported. The practice relevance may provide new perspectives on the neural substrates of chemosensation and potential targets for taste-related interventions.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
The caudate nucleus, a key component of the dorsal striatum, has traditionally been recognized for its roles in motor control and cognitive functions. However, emerging neuroimaging and neurophysiological findings show its crucial involvement in gustatory function as well. The papers analyzed in this comprehensive overview indicate that the caudate nucleus and dorsal striatum exhibit consistent activation during gustatory stimulation, respond to different metabolic states, motivation, and hedonic value, and interact with regions involved in reward and emotional processing across health and disease. Even if these results are promising, experimental designs are frequently heterogeneous, so more evidence is needed to elucidate the link between taste and these subcortical regions. This approach may provide new perspectives on the neural substrates of chemosensation and potential targets for taste-related interventions.
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