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Citrus bergamia nutraceuticals significantly reduce body weight and BMI in patients with obesityCitrus bergamia supplements linked to weight loss in review

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Key Takeaway
Consider Citrus bergamia nutraceuticals as a potential adjunct for weight loss and BMI reduction in patients with obesity.

This meta-analysis synthesized data from 11 RCTs to evaluate the impact of nutraceuticals containing Citrus bergamia on weight management in adults with obesity. The analysis focused on primary outcomes including body weight, BMI, and waist circumference, alongside secondary measures such as waist-to-hip ratio and body fat percentage.

The meta-analysis found that Citrus bergamia was associated with a significant decrease in body weight (SMD -0.64; 95% CI -1.15, -0.13; p = 0.01) and BMI (SMD -0.85; 95% CI -1.35, -0.35; p = 0.0008). Additionally, waist circumference significantly decreased (SMD -0.41; 95% CI -0.65, -0.16; p = 0.001). However, no significant effects were observed for body fat percentage or waist-to-hip ratio.

The authors noted high heterogeneity in the results, specifically I = 90% for weight and BMI, and I = 49% for waist circumference. While these findings suggest that Citrus bergamia may be useful in the management of obesity, clinical application should be tempered by the observed variability between studies.

How this fits prior evidence

This finding addresses a gap in nutraceutical options for obesity management. It complements existing evidence regarding weight management adjuncts, such as oral white kidney bean extract which reduced weight by 1.62 kg in adults with overweight or obesity. While Citrus bergamia shows promise for reducing BMI and waist circumference, it provides an alternative to lifestyle interventions or pharmacological agents like semaglutide mentioned in prior coverage.

If you're struggling with weight loss, a citrus fruit called bergamot might offer some help. A new analysis of 11 clinical trials found that supplements containing Citrus bergamia led to significant drops in body weight, body mass index (BMI), and waist circumference in adults.

The review pooled data from 11 randomized controlled trials, each lasting at least 4 weeks. People taking the supplements lost more weight and inches compared to those who didn't. The effects were moderate but consistent.

However, the results come with important caveats. The studies varied widely (high heterogeneity), meaning the findings aren't rock-solid. Also, the supplements didn't budge waist-to-hip ratio or body fat percentage. The strongest benefits appeared in trials lasting 12 weeks or less, with doses of 600 mg per day or less, and in people who were already overweight or obese.

No safety data were reported in the review, so it's unclear if there are side effects. Talk to your doctor before trying any supplement for weight loss.

What this means for you:
Bergamot supplements may help with weight loss, but the evidence is mixed and limited.

Common questions

What is Citrus bergamia?

Citrus bergamia is a citrus fruit, also known as bergamot orange. Its extract is used in some dietary supplements. This review looked at nutraceuticals containing Citrus bergamia for weight loss.

How much weight did people lose with Citrus bergamia?

The review didn't report exact pounds lost. It used a measure called standardized mean difference (SMD). For body weight, the SMD was -0.64, which is a moderate effect. The results were statistically significant.

Are there any side effects of Citrus bergamia supplements?

The review did not report any information on side effects, serious adverse events, or how well people tolerated the supplements. So it's unknown if there are risks. Always check with a doctor before starting a new supplement.

Who might benefit most from these supplements?

The review suggests that benefits were strongest in studies lasting 12 weeks or less, with doses of 600 mg per day or less, and in people who were overweight or obese. But individual results may vary.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the effect of nutraceuticals containing Citrus bergamia on the management of obesity in adults by assessing measures related to obesity. We searched the following databases until October 2024: PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials. The inclusion criteria were RCTs involving adults (≥ 18 years), the use of nutraceuticals containing C. bergamia, and an intervention duration of ≥ 4 weeks. Data extraction focused on weight loss, body mass index, waist circumference, waist-to-hip ratio, and body fat percentage, and the risk of bias was assessed using the Revised Cochrane Risk-of-Bias Tool. Out of 966 reports, 11 RCTs were eligible for inclusion in the meta-analysis. The pooled results, using a random-effects model, showed that C. bergamia supplementation significantly decreased body weight (SMD: -0.64; 95% CI: -1.15, -0.13; p = 0.01; I = 90%), body mass index (SMD: -0.85; 95% CI: -1.35, -0.35; p = 0.0008; I = 90%), and waist circumference (SMD: -0.41; 95% CI: -0.65, -0.16; p = 0.001; I = 49%). However, no significant effect of bergamot-containing nutraceuticals was observed on the other body composition parameters analyzed. Subgroup analysis suggested that bergamot intake significantly changed anthropometric parameters for periods of ≤ 12 weeks, at dosages of ≤ 600 mg/day, and among participants with overweight and obesity. Overall, the current meta-analysis suggests that nutraceuticals containing C. bergamia show promise in the prevention and management of obesity. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO): CRD42023465541 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=465541).
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