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Survival differed significantly among central venous access strategies for parenteral nutrition in elderly patients with dysphagia.

Survival differed significantly among central venous access strategies for parenteral nutrition in e…
Photo by Olga Kononenko / Unsplash
Key Takeaway
Note significant survival differences among central venous access strategies in elderly dysphagia patients, but data are limited.

A retrospective cohort study evaluated central venous access strategies for parenteral nutrition in 73 patients aged 65 years or older with dysphagia. The analysis compared survival outcomes among patients receiving an implanted central venous access port (ICVAP), a non-tunneled central venous catheter (NT-CVC), or a peripherally inserted central catheter (PICC). The study setting was not reported.

Main results indicated that survival differed significantly among the three groups, with a log-rank p-value of less than 0.05. However, the text did not report exact survival rates, hazard ratios, or confidence intervals for these differences, limiting the ability to quantify the magnitude of the effect.

Safety and tolerability data were not detailed in the provided results. The study did not report specific adverse events, serious adverse events, discontinuation rates, or general tolerability metrics for any of the access strategies. Consequently, a direct comparison of safety profiles between ICVAP, NT-CVC, and PICC in this population cannot be made based on the available information.

Key limitations include the small sample size of 73 patients and the absence of reported funding or conflict of interest statements. The observational nature of the study precludes causal inferences regarding the impact of access type on survival. Practice relevance is constrained by the lack of granular outcome data and safety information, suggesting that these findings should be viewed as preliminary.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundDysphagia in older adults often necessitates long term parenteral nutrition (TPN). However, the optimal central venous access strategy, including implantable central venous access port (ICVAP), non-tunneled central venous catheter (NT-CVC) or peripherally inserted central catheter (PICC), remains uncertain, particularly regarding survival and complication risk.MethodsThis retrospective cohort study included 73 patients aged ≥65 years with dysphagia who received parenteral nutrition via ICVAP, NT-CVC, or PICC. Device selection was based on patient/family request and feasibility/acceptability at the discharge destination. Baseline characteristics were compared using ANOVA and chi-square/Fisher’s exact tests, and standardized mean differences (SMD) were reported to quantify baseline imbalance. Survival was evaluated using Kaplan–Meier curves with log-rank tests. Multivariable Cox proportional hazards models were performed to adjust for predefined covariates. Short-term mortality and complications were compared using chi-square or Fisher’s exact tests.ResultsSurvival differed significantly among the three groups (log-rank p 
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