Elevated uric acid-to-albumin ratio associated with increased all-cause mortality in Chinese centenarians
This prospective cohort study included 924 centenarians from China Hainan, derived from an initial sample of 1,002 after exclusions. The primary exposure was the uric acid-to-albumin ratio (UAR), categorized into quartiles. The lower three quartiles (Q1–Q3) served as the reference group against which the highest quartile (Q4) was compared. The primary outcome was all-cause mortality, with follow-up extending through March 31, 2023, yielding a median duration of 29.70 months.
Analysis revealed a statistically significant overall association between UAR and mortality (adjusted P = 0.009). Specifically, individuals in the highest UAR quartile (Q4) exhibited an increased risk of mortality compared to those in the lower three quartiles. The adjusted hazard ratio for Q4 versus Q1–Q3 was 1.287 (95% CI: 1.093, 1.516; P = 0.003). Additionally, median survival time was shorter in the Q4 group (26 months) compared to the reference group (32 months), with a log-rank test P value of less than 0.001.
No adverse events, serious adverse events, discontinuations, or tolerability data were reported, as this was an observational mortality study rather than a clinical trial. The study design precludes definitive causal conclusions regarding UAR and mortality. While the association appears robust within this specific population, the results may not be generalizable to other age groups or ethnicities. Clinicians should interpret these data as indicative of an association rather than a direct causal mechanism.
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