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Home nutrition support improves quality of life in adults during first 4 months of treatmentHome nutrition support improves quality of life for adult patients

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Key Takeaway
Note that home nutrition support is associated with significant quality of life improvements during the first 4 months.

This meta-analysis evaluates the impact of home nutrition support (HNS), including home enteral nutrition (HEN) and home parenteral nutrition (HPN), on quality of life (QoL) in adults. The analysis assessed QoL and its physical and psychosocial domains at 1, 2, 3, 4, and 6 months following the initiation of HNS.

The analysis found statistically significant improvements in QoL from baseline at 1 month (effect size 0.29), 2 months (effect size 0.54), 3 months (effect size 0.64), and 4 months (effect size 0.61). However, the improvement at 6 months (effect size 0.09) did not reach statistical significance (95% CI: -0.20 to 0.38). The data suggest a descriptive temporal trend where the most substantial improvements occurred between 2 and 4 months.

A noted limitation is that the studies contributing to each specific time point differed, which may affect the consistency of the longitudinal data. Clinical application is limited by the lack of statistical significance at the 6-month mark and the variation in study populations across time points. The findings suggest that HNS may provide significant QoL benefits during the initial months of therapy.

Living with a condition that requires home nutrition support, like enteral or parenteral nutrition, can be a long and difficult journey. New data shows that these patients often experience a meaningful boost in their overall quality of life during the early stages of their treatment.

Researchers looked at how patients felt at several points after starting home nutrition support. They found that quality of life scores improved significantly at the one, two, three, and four-month marks. The most notable improvements were seen between the second and fourth months of care.

While the initial months show a clear upward trend in well-being, the data for the six-month mark did not reach statistical significance. It is also important to note that the specific studies looked at for each time point were different, which can make long-term comparisons a bit less certain. For now, the early months of home nutrition support appear to offer a period of significant improvement for these patients.

What this means for you:
Adults on home nutrition support see significant quality of life improvements during the first four months of care.

Common questions

How does home nutrition support affect quality of life?

Adults receiving home nutrition support, including enteral and parenteral options, showed statistically significant improvements in their quality of life during the first four months of treatment. The largest improvements in these scores were observed between the second and fourth months after starting the program.

Are there long-term benefits to home nutrition support?

While there is a clear improvement in quality of life during the first four months, the data for the six-month mark did not reach statistical significance. Because the studies used to measure each time point were different, the long-term trend is less certain.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
BackgroundHome nutrition support (HNS), including home enteral nutrition (HEN) and home parenteral nutrition (HPN), is widely used in patients who cannot meet their nutritional requirements through oral intake alone. However, longitudinal changes in quality of life (QoL) following HNS have not been systematically synthesized.MethodsPubMed, Embase, Web of Science, CNKI, Wang fang, VIP, SinoMed, and the Cochrane Library were searched from inception to June 2026 to identify longitudinal studies evaluating QoL among adults receiving HNS. The methodological quality of included studies was assessed. QoL changes at 1, 2, 3, 4, and 6 months after HNS initiation were compared with baseline and synthesized using meta-analysis.ResultsEighteen studies were included. The pooled SMDs at 1, 2, 3, 4, and 6 months were 0.29, 0.54, 0.64, 0.61, and 0.09, respectively. The 1 to 4 month estimates were statistically significant, while the 6 month estimate was not (95% CI: −0.20 to 0.38). Descriptive evidence from three non-pooled studies suggested possible improvements in the physical and psychosocial domains of QoL.ConclusionsPatients receiving HNS experienced statistically significant improvements from baseline in QoL during the first 1–4 months, with the largest pooled estimates observed between 2 and 4 months. The improvement was smaller at 6 months and did not reach statistical significance. The pattern suggests a descriptive temporal trend, though the studies contributing to each time point differed. Further longitudinal studies with longer follow-up are needed to clarify the long-term changes of QoL among patients receiving HNS.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420261414696, identifier: CRD420261414696.
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