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Cross-sectional study links current CBD use to lower physical activity and altered biomarkers in recreational female usersWhy CBD Users Move Less

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Key Takeaway
Note that current CBD use associates with lower physical activity and altered biomarkers in recreational female users.

This cross-sectional study evaluated 149 recreationally active female users aged 18–40 years in a real-world setting. The cohort included a survey-only group and a biomarker subcohort of 20 participants. Current cannabidiol users were compared against non-users, defined as those who were past or never users combined. The primary outcome assessed behavioral and physiologic health correlates, while secondary outcomes included physical activity, dietary patterns, sleep quality, mental health, quality of life, pain, and blood biomarkers. Follow-up duration was not reported.

Analysis revealed that total MET-minutes were lower in CBD users (6,627 ± 5,344) compared to non-users (11,301 ± 9,805), with a p-value less than 0.01. Sleep duration was shorter in CBD users with a p-value less than 0.001. Quality of life measures were also lower in CBD users (p < 0.01). Dietary quality was higher in CBD users (p < 0.01), and tobacco use was greater in CBD users (p = 0.04). Mental health scores were lower in CBD users, though this difference was not statistically significant. Post-exercise pain showed no difference between groups.

Regarding biomarkers, basophil counts, sex hormone-binding globulin, and testosterone levels were higher in non-users (p = 0.02, p = 0.04, and p < 0.01, respectively). Thyroid-stimulating hormone was lower in non-users (p = 0.05). Safety data, including adverse events, serious adverse events, discontinuations, and tolerability, were not reported. Limitations include the cross-sectional design, real-world setting, and the fact that only a subset completed the biomarker panel. Funding or conflicts of interest were not reported.

Many women turn to CBD oil to feel relaxed after a workout or to sleep better at night. But a new study suggests the opposite might be happening for some active women.

The Surprising Shift

For years, people assumed CBD was a magic helper for recovery and stress. The idea was simple: take a drop, feel calm, and get back to your routine. But this research looks at real women who actually use these products.

Millions of women use CBD daily. Most of us think it helps us sleep or relax. However, this study found that current users are moving less than those who do not use it. They also reported sleeping fewer hours. This is frustrating because we use these products to feel better, not worse.

What Scientists Didn't Expect

We used to believe CBD was a universal helper for everyone. It seemed like a safe, natural way to unwind. But here's the twist: the data shows a different picture for active women.

Think of your body like a busy city. CBD acts like a traffic signal that tells your system to slow down. This is great for pain or anxiety. But if you are trying to build stamina or recover from exercise, that "slow down" signal might interfere with your energy levels. It's like trying to run a marathon while someone keeps pressing the brake pedal.

Researchers looked at 149 active women between the ages of 18 and 40. They asked about their diet, sleep, and exercise habits. A smaller group of 20 women also gave blood samples. The team compared women who currently use CBD to those who never used it or stopped using it.

The most important finding is about movement. Women who use CBD reported significantly less physical activity. On average, they burned far fewer calories during the week. They also said they slept less than non-users.

This doesn't mean this treatment is available yet.

Diet quality was slightly better for users, but they smoked more tobacco. Pain after exercise did not change. The blood tests showed small differences in hormones, but most values were still within normal ranges.

The Surprising Shift

The study shows that CBD use is linked to a specific lifestyle. These women might be using it because they are already stressed or tired. Or, the product might be making them less active. We do not know which comes first.

Doctors say this is a complex issue. It is hard to tell if CBD causes low activity or if people with low activity choose to use CBD. More research is needed to understand the link.

If you use CBD, pay attention to your energy levels. Are you moving less than usual? Are you sleeping less? Talk to your doctor about your habits. Do not stop using a product you like without advice, but be honest about your activity levels.

This study only looked at women. It did not include men. It was a snapshot in time, not a long-term study. The group was small. These factors limit what we can conclude.

Scientists will need to study more people over a longer time. They want to know if CBD changes how our bodies work during exercise. Until then, listen to your body and track your own progress.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
IntroductionCannabidiol (CBD) use has increased substantially in the United States alongside expanding legalization of cannabis and hemp-derived products. CBD is widely marketed for recovery, sleep, stress reduction, and overall well-being, yet evidence supporting these claims in healthy, physically active populations remains limited and mixed. Most controlled trials have been conducted in predominantly male cohorts, and emerging data suggest potential sex differences in CBD pharmacokinetics, underscoring the need to characterize female users.MethodsThis cross-sectional study examined behavioral and physiologic health correlates of real-world CBD use among recreationally active women aged 18–40 years. Participants completed validated assessments of physical activity (IPAQ), dietary patterns (PrimeScreen), sleep quality (PSQI), mental health (SFMHC), quality of life (QOL), and pain (VAP); a subset completed a 50-marker fasting blood panel. Current CBD users were compared to non-users (past and never users combined).ResultsIn the survey-only cohort (n = 149; 78 current users), CBD users reported significantly lower total MET-minutes (6,627 ± 5,344 vs. 11,301 ± 9,805; p < 0.01), shorter sleep duration (p < 0.001), and lower quality of life measures (p < 0.01). Mental health scores were lower but not statistically significant. Dietary quality was slightly higher among users (p < 0.01), though tobacco use was greater (p = 0.04). Post-exercise pain did not differ. In the biomarker subcohort (n = 20), non-users demonstrated higher basophils (p = 0.02), sex hormone-binding globulin (p = 0.04), and testosterone (p < 0.01), and lower thyroid-stimulating hormone (p = 0.05), with most values within reference ranges.DiscussionCBD use clustered with distinct behavioral and psychosocial characteristics, warranting longitudinal, sex-specific investigation.
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