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Mediterranean diet adherence linked to reduced cardiovascular events and mortality in established CVDMediterranean diet linked to lower risk of repeat heart problems and death

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Key Takeaway
Consider Mediterranean diet recommendations for secondary CVD prevention, but note varying evidence quality.

This systematic review and meta-analysis examined the association between adherence to the Mediterranean diet and cardiovascular outcomes in individuals with established cardiovascular disease (CVD). The analysis included over 91,000 participants from both observational cohort studies and randomized controlled trials, though specific study settings and follow-up durations were not reported. The comparator was not explicitly defined, but the analysis compared higher versus lower adherence to the Mediterranean dietary pattern.

For major adverse cardiovascular events, the meta-analysis found a reduced risk in both cohort studies (RR 0.95, 95% CI: 0.93-0.97) and randomized trials (RR 0.44, 95% CI: 0.20-0.94). Mortality risk was also reduced in cohorts (RR 0.96, 95% CI: 0.95-0.98) and randomized trials (RR 0.27, 95% CI: 0.13-0.55). However, effects on intermediate health outcomes including blood pressure, lipid profile, and body composition were not statistically significant.

Safety and tolerability data were not reported in the analysis. Key limitations were not specified in the provided evidence, and funding sources or conflicts of interest were not reported. The certainty of evidence ranged from low to high depending on the specific outcome. While these findings support incorporating Mediterranean diet recommendations into secondary prevention strategies, clinicians should note the varying evidence quality and the non-significant effects on traditional cardiovascular risk factors.

Researchers analyzed many existing studies to see if following a Mediterranean diet helps people who already have heart disease. They looked at data from over 91,000 participants across different types of research, including observational studies and clinical trials. The Mediterranean diet emphasizes fruits, vegetables, whole grains, olive oil, nuts, and fish.

The main finding was that people who followed this diet more closely had a lower risk of having another serious heart problem or dying from heart disease. The reduction in risk was seen in both the long-term observational studies and the shorter clinical trials. However, the analysis did not find that the diet significantly improved common health markers like blood pressure, cholesterol levels, or body weight in this group.

No safety issues with the diet were reported in the review. The main reason to be careful is that this is a summary of other studies, not a new experiment. It shows a strong and consistent link, but other lifestyle factors could also play a role. The certainty of the evidence varied for different outcomes. For people with heart disease, this adds support to existing health advice about healthy eating patterns, but it's best to discuss any major dietary changes with a doctor.

What this means for you:
For people with heart disease, a Mediterranean diet pattern is linked to better long-term health, but it's one part of overall care.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BACKGROUND: Cardiovascular diseases (CVD) are the leading cause of mortality worldwide, with secondary prevention a public health priority. Diet is a modifiable risk factor, and adherence to the Mediterranean diet (MD) has shown benefits in primary prevention. However, its role in patients already affected by CVD remains uncertain. This systematic review and meta-analysis aimed to evaluate the association between adherence to MD and recurrent cardiovascular events, mortality, and intermediate health outcomes in individuals with established CVD. METHODS: This review was conducted in accordance with PRISMA 2020 and MOOSE guidelines. A comprehensive search of PubMed/MEDLINE, Scopus, Embase, and Cochrane Library was performed up to February 28, 2024. The certainty of evidence was evaluated with the NUTRIGRADE approach. Pooled effect sizes were computed using a random-effects model and expressed as risk ratios (RR), hazard ratios, or odds ratios, as appropriate. RESULTS: Nineteen studies (4 randomized controlled trials-RCTs, 15 cohorts) involving over 91 000 participants were included. Higher adherence to MD was associated with a reduced risk of major adverse cardiovascular events in cohorts (RR 0.95, 95% CI: 0.93-0.97) and RCTs (RR 0.44, 95% CI: 0.20-0.94), and reduced mortality in cohorts (RR 0.96, 95% CI: 0.95-0.98) and RCTs (RR 0.27, 95% CI: 0.13-0.55). Effects on blood pressure and lipid profile were not significant, while effects on body composition were non-significant. Certainty of evidence ranged from low to high depending on the different outcomes. CONCLUSIONS: Higher adherence to the MD is associated with clinically meaningful reductions in recurrent cardiovascular events and mortality among CVD patients. These findings support incorporating MD-based recommendations into secondary prevention guidelines and public health strategies.
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