Sentinel lymph node technique assessed in multifocal breast cancer (n=216)Can doctors find the first lymph node cancer might reach in women with multiple breast tumors?

For women diagnosed with breast cancer that has formed multiple separate tumors in the same breast—called multifocal cancer—a key question is whether the cancer has started to spread to the lymph nodes under the arm. Doctors wanted to see if a technique for finding the 'sentinel' lymph node, which is the very first node cancer would likely reach, would work reliably in this specific situation. In this study, they tested the method on 216 women. The procedure involved injecting a combination of a blue dye and a tiny, safe amount of a radioactive tracer near the nipple, either the day before or the day of surgery. If a woman was allergic to the dye, they used only the tracer, and if the tracer couldn't be used, they used only the dye. Right after this mapping step, surgeons performed a complete axillary lymph node dissection, removing all the lymph nodes from under the arm during the woman's breast cancer surgery. The main goal was to see the 'detection rate'—how often they could successfully find and remove that first sentinel node. After surgery, pathologists examined two sets of tissue: the sentinel node they had mapped and all the other lymph nodes that were removed. They also confirmed from the breast tissue that the cancer was truly multifocal. The study's finding for each patient was complete once this analysis was done. The results help doctors understand if this targeted node-mapping approach is a viable first step for women with multiple tumors, potentially guiding less invasive surgery.