Medical Reviewer
Dr. Sofia Müller, MD
Lifespan & Whole-Person Care — Population health, longitudinal cohorts, care-delivery and goals-of-care research.
Dr. Sofia Müller is a freelance medical writer and physician based in Basel, Switzerland, specializing in Lifespan & Whole-Person Care with over 9+ years of combined clinical and medical writing experience. She holds an MD from the University of Zurich and is board-certified in Internal Medicine and Geriatrics. She also holds additional training in public health, palliative care, and clinical epidemiology.
Sofia focuses on population health research, longitudinal cohort studies, and care delivery models across pediatrics, women's health, geriatrics, palliative care, and primary care medicine. She has extensive experience working on studies related to aging populations, chronic disease management, and integrated care systems.
Before transitioning into medical writing, she practiced as a hospital-based internist and geriatrician, where she developed a strong interest in health systems research and patient-centered care frameworks. She is known for her ability to translate complex clinical and population-level data into clear, actionable scientific communication for diverse audiences.
Articles in this group — last 14 days
Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
Twelve patients with early memory loss received young donor blood plasma safely.
This pilot study examined the safety and feasibility of replacing patient plasma with that from young donors in twelve individuals with mild…
Twelve patients with early memory loss received young donor blood plasma safely. The procedure was feasible and well tolerated.
MiniDock MTB Test Shows High Sensitivity and Specificity for Tuberculosis Detection
A new test finds TB in people who cough up nothing
This prospective cross-sectional study evaluated the MiniDock MTB test using sputum and tongue swabs in 1380 patients with presumptive pulmo…
A new test found tuberculosis in over 85% of patients who could not produce a cough sample, offering a faster way to diagnose the disease in…
Meta-analysis shows clear aligners produce less skeletal expansion than conventional appliances in growing patients
Clear Aligners Produce Less Skeletal Expansion Than Conventional Appliances
This systematic review and meta-analysis evaluated clear aligners versus conventional expansion appliances for maxillary transverse deficien…
A review of 15 studies finds clear aligners create less skeletal expansion than traditional devices for growing patients with maxillary tran…
Study protocol for screening nulliparous women to prevent preeclampsia and fetal growth restriction
A new plan to screen for pregnancy risks is being tested in a UK hospital.
This study protocol describes a prospective cohort with a nested randomized controlled trial at Rosie Hospital, Cambridge, UK. It plans to r…
A major research plan is starting to test a new way to screen for preeclampsia and fetal growth restriction in pregnant women.
Congenital urinary tract dilation resolves spontaneously in 96.2% of children over 3 to 44 months follow-up.
Most urinary tract dilation in babies goes away without surgery
This retrospective cohort study evaluated 341 children with congenital urinary tract dilation at Adiyaman University Pediatric Nephrology Cl…
New research shows most urinary tract dilation in babies resolves naturally without needing surgery or invasive procedures
Radiopharmacy services and staffing patterns in South African academic hospitals
Hospital staffing gaps found in South African nuclear medicine
This retrospective, descriptive, and quantitative cohort study examined radiopharmacy services and staffing across 7 South African academic …
A study of South African academic hospitals reveals significant shortages in radiopharmacist staffing despite available imaging technology.
Permanent night shift work associated with increased chronic kidney disease risk in UK Biobank participants
Permanent night shift work linked to kidney disease risk
This prospective cohort study of UK Biobank participants found an association between permanent night shift work and increased risk of incid…
Working permanent night shifts may increase your risk of developing chronic kidney disease, according to a large study of UK Biobank partici…
Lower rest-activity rhythm parameters associated with increased abdominal aortic aneurysm risk
Irregular daily activity rhythms may increase aneurysm risk
This cohort study of 78,282 UK Biobank participants found that lower accelerometer-derived rest-activity rhythm parameters are associated wi…
Your body's daily rhythm might hold clues to preventing abdominal aortic aneurysms, a dangerous swelling in the body's main artery.
Mini-review discusses post-discharge care transitions for people living with HIV
Hospital discharge transitions impact outcomes for people with HIV
This mini-review examines post-discharge care transitions for hospitalized people living with HIV, particularly in low-income settings. The …
Recent data shows that nearly one in five people with HIV are readmitted to the hospital after being discharged in low-income settings.
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models
E-cigarette flavors may increase nicotine use and health risks
This systematic review examines the health impacts of fruity, menthol/mint, and sweet e-cigarette flavors using animal models and human data…
Sweet, fruity, and minty e-cigarette flavors are linked to higher nicotine use and serious respiratory and cellular damage.
Containment surgery and radiographic outcomes in children with Waldenström stage III LCPD
Surgery shows potential benefits for advanced Legg-Calvé-Perthes disease
This retrospective cohort study of 58 children with Waldenström stage III LCPD observed an association between containment surgery and femor…
A study of children with advanced Legg-Calvé-Perthes disease found a trend toward better hip development after containment surgery.
Disease progression and death in a 10 year old male with lower esophageal squamous cell carcinoma
Rare case: child dies 7 months after esophageal cancer diagnosis
This case report and retrospective literature analysis describes a 10 year old male with lower esophageal squamous cell carcinoma. Following…
A 10-year-old with a rare esophageal cancer died 7 months after diagnosis, highlighting the urgent need for better treatments.
Azithromycin to doxycycline switching in children with Mycoplasma pneumoniae pneumonia resistance gene positivity
Testing for resistance genes may guide antibiotic choices
This retrospective cohort study of 150 children with Mycoplasma pneumoniae pneumonia evaluated resistance gene expression and antibiotic man…
New evidence suggests that checking for resistance genes in children with pneumonia could help doctors decide when to switch antibiotics.
Routine lab indicators help differentiate typical from incomplete Kawasaki disease and predict coronary lesions
Lab indicators may help identify Kawasaki disease risks
This retrospective study of 131 children with Kawasaki disease found that total protein was the only independent factor differentiating typi…
Routine blood markers could help doctors better identify Kawasaki disease types and predict potential heart complications in children.
Narrative review discusses telemedicine potential and barriers for new immigrant children in the US
Telemedicine could help bridge healthcare gaps for immigrant children
This narrative review examines the acceptance, accessibility, and feasibility of telemedicine for new immigrant children in the US aged birt…
New immigrant families face massive hurdles in healthcare, but virtual doctor visits might help overcome language and travel barriers.
Large ART cohort shows clinical pregnancy rates around 34% and live birth rates near 25%
A new database reveals how IVF success rates vary across Europe
This retrospective observational cohort study analyzed 64,081 ovarian stimulation cycles from 18 IVF/ICSI centers in Italy and Germany. Clin…
This huge new database tracks real IVF cycles to help doctors understand current success rates and treatment patterns across Europe.
Higher body mass index associated with increased oxidative stress in women undergoing IVF
Higher BMI linked to oxidative stress in infertility treatment
In this prospective observational cross-sectional study, researchers examined the relationship between body mass index and oxidative stress …
A new study shows that a higher BMI may trigger oxidative stress, a chemical imbalance that could impact women undergoing IVF.
Nalbuphine and midazolam show non-inferiority to pethidine and midazolam for oocyte retrieval pain
Nalbuphine Matches Old Painkiller For Egg Retrieval
In this double-blinded, non-inferiority randomized controlled trial of 94 participants, 10 mg intravenous nalbuphine with 5 mg midazolam was…
A new painkiller matches the old standard for egg retrieval without causing more side effects.
Review of national and regional datasets shows stable palliative care time in community nursing from 2013 to 2024
Community nursing referrals rose while time per patient dropped sharply between 2013 and 2024
This review analyzes secondary data from national and regional datasets regarding community health nursing services provision for adults bet…
Referrals to community nursing services grew steadily from 4,000 to 6,000 per 100,000 people, yet time spent per patient fell from over 150 …
Pregnant women unvaccinated against pertussis had infants with higher anti-PT IgG levels at six months
Unvaccinated mothers pass stronger pertussis antibodies to babies than vaccines do
This prospective open-label controlled clinical trial evaluated the effect of immunization during pregnancy on anti-pertussis toxin antibodi…
Antibodies against whooping cough passed from unvaccinated mothers to babies were stronger than those from vaccinated mothers, challenging c…
Valganciclovir dosing in congenital cytomegalovirus infection shows extensive drug accumulation in dried blood spots
New blood test tracks cCMV drug levels in infants
This randomized, placebo-controlled clinical trial (ValEAR) or open-label PK study evaluated infants with congenital cytomegalovirus infecti…
A new blood spot test helps doctors track cCMV medicine levels in babies to prevent dangerous side effects during treatment.
High-dose rifampicin pharmacokinetics differ across sites in tuberculosis infection randomized trial
High-dose rifampicin shows different drug levels in adults across three countries
This randomized controlled trial evaluated adults and adolescents aged ≥ 10 years with tuberculosis infection. Bioavailability was lower in …
Drug levels of high-dose rifampicin varied by country, with lower bioavailability seen in Canada and Vietnam compared to Indonesia in this t…
Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years.
Higher adjuvant content boosts immunity in children without added safety risks
This phase 2, observer-blind, multicenter study evaluated six formulations of MF59-adjuvanted H5N1 vaccine in 420 healthy infants and childr…
A Phase 2 trial in healthy children found that higher adjuvant content improved immune responses to an H5N1 vaccine without increasing side …
Vitamin A Supplementation at Birth Alters Vaccine Immune Responses Without Improving Antibody Levels in Infants
Vitamin A given at birth changes how babies respond to vaccines
This randomized, placebo-controlled trial enrolled 306 infants in Dhaka, Bangladesh receiving 50,000 IU Vitamin A within 48 hours of birth c…
A single vitamin A dose at birth may strengthen some vaccine responses in infants, but results vary by sex and vaccine type.
Systematic review of observational data shows wide variation in primary care discontinuation of lipid-lowering and antihypertensive therapies
Millions of heart patients stop or restart key medicines at alarming rates in primary care
This systematic review of observational data analyzed 9,146,252 patients in primary care regarding discontinuation and restarting of lipid-l…
Nearly one million patients in primary care stopped or restarted heart medicines within a year, with rates varying widely by age and backgro…
Systematic review and meta-analysis shows transitional care reduces readmission and MACE in PCI patients
Transitional Care Cuts Heart Readmission Risk By Half
This systematic review and meta-analysis evaluates transitional care interventions for 3345 patients after percutaneous coronary interventio…
New research shows structured follow-up care after heart stents halves the risk of returning to the hospital and significantly boosts qualit…
Proof of concept research suggests portable PFM systems may offer superior sensitivity for pelvic-floor dysfunction
New 3D scanner spots hidden pelvic floor weakness before symptoms start
This proof of concept research evaluates a portable multi-channel PFM-pressure dynamic measuring system against traditional PFM-evaluating m…
A new 3D scanner detects hidden pelvic floor weakness before symptoms appear, offering a clear path to earlier diagnosis and better treatmen…
Relaxation of COVID-19 control measures in Xiamen associated with specific respiratory infectious disease patterns
Respiratory viruses surge differently after pandemic rules end
This retrospective cohort study examined residents of Xiamen, Fujian Province, China, one year following the relaxation of COVID-19 control …
Flu A became the most common infection after restrictions lifted, with seasonal peaks shifting for kids and adults alike.
Digital engagement associated with positive views on aging in Chinese older adults aged 60 and over.
Digital connection helps older adults feel younger and more active in society
This cohort study examined Chinese older adults aged 60 and over using data from The China Longitudinal Aging Social Survey. Digital engagem…
Using digital tools helps older adults feel younger and more active in society, but the benefit fades slightly as they get older.
Preterm children aged 0–2 years show lower growth rates and IGF-1 levels compared to full-term peers
Preterm babies grow slower due to biology and environment factors
This cohort study followed preterm children aged 0–2 years and compared them to full-term children. Growth rates for length, weight, and hea…
New research shows biology and environment slow preterm baby growth, giving doctors better tools to help them catch up.
Narrative review discusses postoperative care strategies for older adults with hip fracture and cognitive impairment
New care plans help seniors with memory loss recover from broken hips
This narrative review examines postoperative care management strategies for older adults with hip fracture and cognitive impairment. The aut…
New care plans help seniors with memory loss recover from broken hips by reducing confusion and speeding up movement after surgery.
Autologous hematopoietic stem cell transplantation improves disease-free survival in pediatric extraocular retinoblastoma patients
Children With Eye Cancer Now Have a New Hope for Survival
This retrospective analysis included 12 children with extraocular retinoblastoma treated with autologous hematopoietic stem cell transplanta…
Children with advanced eye cancer can now achieve long-term survival using their own stem cells, especially if the disease has not reached t…
Weekend births linked to longer antibiotic exposure in very low birth weight infants with suspected sepsis
Weekend births delay antibiotic stops for fragile newborns
This retrospective cohort study examined antibiotic exposure times in very low birth weight infants with suspected early-onset sepsis and ne…
New research shows babies born on weekends stay on antibiotics longer than those born during the work week.
Supervised exercise in pediatric oncology: low rate of adverse events over 3 years
Kids with cancer stay active safely with new safety rules
This prospective observational study across six pediatric oncology centers documented 178 adverse events (AEs) in 74,083 supervised exercise…
New safety rules mean kids with cancer can exercise without fear of serious harm
Systematic review and meta-analysis identifies factors associated with hearing recovery in pediatric sudden hearing loss
Men and those treated quickly have better hearing recovery after sudden loss
This systematic review and meta-analysis evaluates pediatric patients with sudden sensorineural hearing loss. Male gender and treatment dela…
Men and patients treated within 14 days had better hearing recovery after sudden sensorineural hearing loss. This analysis offers hope for p…
Case report and review of literature on Aggregatibacter actinomycetemcomitans lung infection in a child
Rare lung infection in a child cleared with antibiotics after weeks of worry
This publication is a case report and review of literature focusing on Aggregatibacter actinomycetemcomitans lung infection in pediatrics. I…
An eight-year-old girl with a rare lung infection and chest tumor signs got better with antibiotics. This case shows how doctors can spot un…
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy
Ketamine combos ease pain in kids with less nausea
This network meta-analysis evaluated ketamine-based regimens versus IV ketamine for pediatric procedural sedation in the emergency departmen…
A new analysis reveals a ketamine-propofol mix calms injured children faster and with fewer side effects than ketamine alone.
ICSI yields lower cumulative live birth rate than conventional IVF in non-male factor infertility
Conventional IVF beats ICSI for non-male factor infertility in large Canadian study
This retrospective cohort study using Canadian registry data compared ICSI versus conventional IVF in 140,252 retrieval cycles for non-male …
A major Canadian registry shows conventional IVF delivers more live births than ICSI for couples without male factor infertility.
Meta-analysis Links Abnormal Gestational Weight Gain to Adverse Outcomes in 866,593 Pregnancies
Too much or too little weight in pregnancy changes risks
This systematic review and meta-analysis of multinational cohort data (n=866,593) found that excessive gestational weight gain (GWG) signifi…
Gaining too much or too little during pregnancy shifts the odds for serious health risks, and the effects depend heavily on where a woman li…
Review synthesizes postpartum women perspectives on digital health tools in Alberta
Digital tools help some postpartum mothers but can feel like a burden
This qualitative review synthesizes focus group data from 18 postpartum women in Alberta regarding digital health tools. Participants identi…
A small study of 18 women in Alberta found digital health apps helped structure care but also created new pressures and privacy worries.
FDA Approves Crysvita (burosumab) for X-Linked Hypophosphatemia and Tumor-Induced Osteomalacia
FDA approves new drug Crysvita for rare bone diseases in children and adults.
FDA approved Crysvita (burosumab) for X-linked hypophosphatemia (XLH) in patients 6 months and older and for tumor-induced osteomalacia (TIO…
The FDA approved Crysvita (burosumab) for X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO). It is the first treatment th…
Review of end-of-life acceptance in deceased patients across four European countries
Older Patients More Likely to Accept Death
This retrospective cross-sectional survey review examined GP-assessed acceptance of approaching death among 2,713 deceased adult patients in…
Many people come to terms with dying, and new data shows age and care type play a bigger role than having cancer.
Fetal paracetamol exposure linked to reduced ovarian and uterine volume in girls
Prenatal Paracetamol Linked to Smaller Ovaries and Uterus in Girls
This prospective, observational cohort study examined 3425 eligible participants, including 302 girls examined at follow-up. Fetal exposure …
Prenatal paracetamol exposure is linked to smaller ovaries and uterus in infant girls, raising new questions about long-term reproductive he…
Eltrombopag plus immunosuppression for severe aplastic anemia shows clonal evolution patterns
Treatment for severe anemia reveals two paths to cancer risk
This phase 2 observational study followed 204 patients with severe aplastic anemia treated with immunosuppression plus eltrombopag for a med…
New research tracks cancer risks in severe anemia patients treated with standard therapy over five years
Meta-analysis compares robot-assisted versus laparoscopic surgery for pediatric choledochal cyst.
Robotic surgery cuts complications in kids’ liver surgery
This meta-analysis of retrospective studies in children with choledochal cyst found robot-assisted surgery associated with lower rates of bi…
Kids who had robotic surgery for a rare liver cyst faced far fewer serious complications than those who had standard keyhole surgery, a new …
Omicron linked to multisystem long COVID and GI symptoms in veterans study
Omicron infection raises risk of multisystem long COVID for veterans
This retrospective cohort study of 1,120 veterans at a VA Medical Center found Omicron variants associated with increased multisystem long C…
Omicron variants caused more multisystem long COVID symptoms than earlier strains in a large rural veteran study group.
Conceptual framework review explores blockchain neural networks for smart city environmental governance
New System Helps Cities Track Waste More Securely
This conceptual framework review discusses the potential applicability of a Blockchain-Enhanced Neural Network Framework (BENNF) in smart ci…
A new tech plan uses AI and blockchain to help cities predict electronic waste more accurately and safely for everyone living there.
Cadmium exposure associated with altered liver function biomarkers in middle-aged and older adults
Heavy Metal Exposure Linked to Liver Changes in Older Adults
This cross-sectional study of 451 participants in Northwest China found positive correlations between blood cadmium levels and liver enzymes…
Cadmium and other heavy metals in the blood are linked to altered liver enzymes, suggesting possible liver stress.
Cervical cytology abnormalities and HPV prevalence in Turkish women over 12 years
HPV Testing Reveals Hidden Risks in Young Women
This retrospective cohort study of 76,232 cervical smear records from a Turkish tertiary care center found an overall epithelial cell abnorm…
One in five women under 30 tested positive for high-risk HPV, with some carrying cancer-linked strains without symptoms, changing how early …
Standard physical examination indicators predict sarcopenia risk with high accuracy in a health checkup population.
New Tool Predicts Muscle Loss Years in Advance
This retrospective cohort study evaluated 3,277 participants from routine health exams to assess the discriminative performance of standard …
A free online tool uses basic health data to predict muscle loss years before symptoms appear—giving people a real chance to act early.
Narrative review of multi-agent AI systems highlights ethical risks including opacity and accountability challenges in healthcare.
New AI teams in hospitals create fresh ethical headaches for doctors and patients
This narrative review synthesizes findings from 21 articles regarding multi-agent AI systems in healthcare settings. The authors identify si…
Smart AI teams are changing healthcare, but they also hide mistakes and threaten patient privacy in ways we must fix now.
Umbrella review associates processed meat consumption with higher risks of cancer and chronic disease outcomes.
Processed meat links to higher cancer and heart disease risks
This umbrella review synthesized data from 34 articles and 54 meta-analyses regarding processed meat consumption. It reports associations wi…
Eating more processed meat like bacon or hot dogs increases your risk for serious health problems including cancer and heart disease.
Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
Younger Colon Cancer Patients Live Longer After Surgery
A retrospective cohort study of 4,596 colorectal cancer patients found that early-onset disease (EOCRC) was associated with significantly be…
Even with tougher tumors, younger colon cancer patients are living longer after surgery than older patients, and doctors now have hard data …
Living alone not linked to incident dementia but associated with higher institutionalization risk in a cohort of 2,269 individuals.
Living Alone Does Not Raise Dementia Risk But Increases Care Needs
This French clinic-based cohort study followed 2,269 individuals with cognitive complaints or mild cognitive impairment for a median of 5 ye…
</think>
Undifferentiated Pleomorphic Sarcoma Recurrence Observed two months Postoperatively in Case Report of Gastric Mass
Cancer returns quickly after surgery and chemo for a 71-year-old woman
This case report and literature review describes a 71-year-old female with undifferentiated pleomorphic sarcoma treated with R0 resection, s…
A 71-year-old woman with rare stomach tumors had surgery and chemo, but the cancer came back just two months later.
Leuprolide acetate associated with final adult height exceeding mid-parental height in girls with central precocious puberty
More Than Half of Girls on Puberty Therapy Beat Their Genetic Height Potential
This retrospective cohort study included 73 girls with central precocious puberty or early puberty treated with depot leuprolide acetate. Th…
More than half of girls treated for early puberty ended up taller than their genetic prediction, with younger age at treatment being the key…
Long peripheral catheters reduce infusion failure compared to short catheters in late preterm and term neonates.
Long IVs Beat Short Tubes for Newborns Needing Medicine
This single-center retrospective cohort study evaluated 197 eligible neonates (gestational age ≥34 weeks and birth weight ≥1,500 g) receivin…
Longer IV catheters failed less often than short ones in newborns needing short-term treatment, cutting failure rates nearly in half.
Woodward procedure associated with improved outcomes in pediatric Sprengel deformity patients.
Surgery lifts high shoulder blades in children with great results
This retrospective analysis evaluated 13 pediatric patients with unilateral Sprengel deformity undergoing the Woodward procedure. Outcomes i…
New findings show children with a high shoulder blade from birth can move better and look more normal after surgery is performed by a specia…
GI multiplex PCR testing in children with acute gastroenteritis showed high positivity and guided antibiotic stewardship.
New test cuts guesswork in children’s stomach bugs and changes antibiotic use
This retrospective observational study evaluated GI multiplex PCR testing in 276 children aged ≤14 years admitted with gastroenteritis at a …
A rapid stool test identified the cause in 91% of children with stomach bugs and helped doctors start or stop antibiotics more precisely.
Case report and literature review on mosaic DICER1 mutations and disease stability in a 6-month-old boy
One Baby, Five Tumors, One Tiny Gene Change
This case report and literature review describes a 6-month-old boy with mosaic DICER1 RNase IIIb hotspot mutation and multiple tumors. The a…
A 6-month-old boy developed five different tumors linked to one small gene change, showing how one mutation can drive multiple childhood can…