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DIBH reduces radiation dose to heart and lungs in left-sided breast cancer VMATBreath-hold technique reduces radiation dose to heart during breast cancer treatment

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Key Takeaway
Consider DIBH for dosimetric advantages in left-sided breast cancer VMAT, but clinical benefit remains unconfirmed.

This meta-analysis and systematic review examined 11 studies comparing deep inspiration breath hold (DIBH) versus free breathing (FB) during volumetric modulated arc therapy (VMAT) for left-sided breast cancer. The analysis focused on radiation dose to organs at risk but did not report clinical outcomes, follow-up duration, or study settings.

DIBH was associated with lower mean radiation doses across all measured organs. The standardized mean difference (SMD) was -1.40 Gy for heart dose, -1.65 Gy for left anterior descending coronary artery dose, -0.57 Gy for ipsilateral lung dose, -0.46 Gy for contralateral lung dose, and -0.20 Gy for contralateral breast dose. The analysis did not provide absolute dose values or confidence intervals for these estimates.

No safety, tolerability, or adverse event data were reported. The review did not describe study limitations, funding sources, or conflicts of interest. While the dosimetric reductions suggest potential clinical benefits for reducing cardiac and pulmonary toxicity, the absence of clinical outcome data limits definitive conclusions about patient benefit.

The authors recommend DIBH for patients undergoing VMAT, particularly with tumor bed boost or without nodal irradiation, based on its effectiveness in reducing heart dose. However, clinicians should interpret these findings cautiously as they represent dosimetric associations rather than demonstrated clinical outcomes.

Researchers reviewed 11 studies to compare two techniques used during radiotherapy for left-sided breast cancer. They looked at a special breathing technique called deep inspiration breath hold (DIBH), where patients hold a deep breath during treatment, versus normal free breathing (FB). All patients were treated with a modern radiation method called VMAT.

The review found that using the DIBH technique consistently resulted in lower average radiation doses to several organs near the treatment area. Specifically, the heart, a key heart artery (the LAD), both lungs, and the opposite breast received less radiation when DIBH was used.

This is important because reducing radiation to the heart and lungs may lower the risk of long-term side effects, like heart disease or lung problems, which are concerns after breast cancer treatment. The study did not report on any immediate safety issues or side effects from using the breath-hold technique itself.

It's crucial to understand that this review only analyzed radiation dose measurements from past studies. It did not follow patients over time to see if the lower doses from DIBH actually led to fewer cases of heart disease or better survival. More research is needed to confirm those long-term benefits. Patients should discuss the potential pros and cons of DIBH with their radiation oncology team.

What this means for you:
A breathing technique lowers heart radiation dose, but long-term health benefits need more study.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJan 2026
View Original Abstract ↓
This meta-analysis aimed to determine the effect of deep inspiration breath hold (DIBH) compared with free breathing (FB) on dose to the organs at risk (OARs), such as the heart, left anterior descending (LAD) coronary artery, lungs, and contralateral breast, in patients with left-sided breast cancer treated with volumetric modulated arc therapy (VMAT). PubMed, EMBASE, and Cochrane Library electronic databases were searched for studies until March 21, 2024. Cochrane RevMan version 5.4 statistical software was used to analyze 11 eligible studies. Standard mean difference (SMD), with 95% confidence interval for OAR dose reductions, was calculated. DIBH considerably resulted in lower mean doses (Dmean) to the heart (SMD =  -1.40 Gy), LAD (SMD = -1.65 Gy), ipsilateral lung (SMD = -0.57 Gy), contralateral lung (SMD = -0.46 Gy), and contralateral breast (SMD = -0.20 Gy). If VMAT was delivered with an arc of >180O, the heart Dmean reduction was even more pronounced. Subgroup analysis revealed that DIBH efficiently reduced heart Dmean, especially in patients with tumor bed boost without nodal irradiation. DIBH was effective in reducing dose to OARs in patients treated with VMAT in all subgroups, i.e., breast only, with/without tumor bed boost, and with/without nodal irradiation. Furthermore, the use of DIBH is strongly recommended for patients undergoing VMAT with a tumor bed boost or without nodal irradiation, as it is more effective in reducing heart Dmean than FB.
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