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A 13-year-old female presented with an invasive encapsulated follicular variant of papillary thyroid carcinomaRare thyroid cancer found in 13-year-old girl

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Key Takeaway
Note that this case report describes a rare thyroid carcinoma in a pediatric patient with limited generalizability.

This case report and literature review describes a single instance of invasive encapsulated follicular variant of papillary thyroid carcinoma identified in a 13-year-old female patient. The clinical presentation included a hypoechoic nodule measuring 3.4 cm x 2.2 cm x 2.5 cm located in the left lobe, characterized by a regular shape and well-defined margins.

The report provides specific details regarding the ultrasound findings of this single case. However, because the data is derived from an individual patient rather than a large cohort or clinical trial, it does not provide broad evidence for general clinical trends or diagnostic probabilities in pediatric populations.

A primary limitation of this report is the small sample size (n=1). Clinical decisions and management strategies should be based on established guidelines rather than this single case report. The findings are specific to this individual's presentation and may not represent the typical course of the disease.

A 13-year-old girl was diagnosed with a rare form of thyroid cancer called invasive encapsulated follicular variant of papillary thyroid carcinoma. Doctors found a 3.4 cm by 2.2 cm by 2.5 cm nodule in her left thyroid lobe. The nodule was hypoechoic, meaning it appeared dark on ultrasound, but had a regular shape and well-defined edges.

This type of cancer is uncommon, especially in children. The case report, which also reviewed existing medical literature, highlights that this tumor can be tricky to diagnose because it looks similar to other thyroid conditions. The girl's case adds to the small number of reported instances in young people.

Because this is a single case report, it cannot tell us how common this cancer is or how it typically behaves. More research is needed to understand the best way to treat it. For now, doctors should be aware that this rare cancer can occur in teenagers and may require careful evaluation.

What this means for you:
A rare thyroid cancer variant was found in a 13-year-old, showing it can occur in young people.

Common questions

What is invasive encapsulated follicular variant of papillary thyroid carcinoma?

It is a rare type of thyroid cancer. The tumor has a capsule around it but shows signs of invasion into nearby tissue. It can be hard to diagnose because it looks like other thyroid nodules on ultrasound.

How was the cancer found in this case?

Doctors used ultrasound and found a 3.4 cm by 2.2 cm by 2.5 cm nodule in the left lobe of the thyroid. The nodule was hypoechoic (dark on ultrasound) but had a regular shape and well-defined margins.

Is this cancer common in children?

No, it is very rare. This case report describes it in a 13-year-old girl, but most cases occur in adults. Because it is a single case, we don't know how often it happens in young people.

What are the limitations of this study?

This is a case report of just one patient, so the findings may not apply to others. It cannot tell us about typical outcomes or the best treatment. More research is needed.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (IEFVPTC) is a well-differentiated malignant thyroid tumor. The 2022 WHO 5th edition classification of endocrine tumors recognizes it as an independent entity. It is more common in adults and rare in children. This report describes a 13-year-old female patient who presented with a neck mass. Ultrasound revealed a 3.4 cm×2.2 cm×2.5 cm hypoechoic nodule in the left lobe, exhibiting regular shape, well-defined margins, an aspect ratio
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