Patients taking certain medications, such as antiresorptive or antiangiogenic agents, face a higher risk of medication-related osteonecrosis of the jaw (MRONJ) during dental procedures. This condition can cause significant bone loss and pain after tooth extractions. Researchers looked at whether adding platelet-rich fibrin (PRF)—a substance derived from the patient's own blood—could improve safety and healing outcomes.
The analysis of 512 patients found that using PRF was associated with a significantly lower risk of developing MRONJ compared to extraction alone. Additionally, patients who received PRF showed better overall healing after surgery. Specifically, a subtype called L-PRF showed significant improvements in healing times.
While these results are promising, it is important to note that the evidence currently has a very low certainty rating. Most of the data came from observational studies with small sample sizes and a high risk of bias. Because the findings are based on these limited types of studies, doctors should view this as an association rather than a guaranteed clinical outcome.
