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Breast cancer mortality in older US adults declines but slowdown after 2014 and disparities persistBreast Cancer Deaths Fall, But Gains Slow After 2014

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Key Takeaway
Note the slowing breast cancer mortality decline after 2014 and persistent disparities in older adults.

This population-based repeated cross-sectional mortality analysis assessed breast cancer mortality among US adults aged 65 years and older, drawing on 544,812 total deaths (538,489 women; 6,323 men). It is a descriptive mortality analysis, not a clinical trial, and does not evaluate interventions or comparators.

The pooled female-specific age-adjusted mortality rate was 99.84 per 100,000 women, while the male breast cancer age-adjusted mortality rate was 1.70 per 100,000 men. Combined-sex age-adjusted mortality declined from 71.58 to 50.83 per 100,000 population between 1999 and 2020, but the decline slowed after 2014.

The authors highlight persistent age, racial, ethnic, and geographic disparities in breast cancer mortality among older adults. They suggest a need for targeted strategies in screening, diagnosis, and geriatric oncology care. The report identifies disparities but does not establish specific causes for them.

Limitations were not reported, and funding or conflicts of interest were not reported. Because this is an observational mortality analysis, the findings cannot establish causality. The slowing decline after 2014 and the noted disparities warrant attention, but the analysis does not explain their drivers.

How this fits prior evidence

This mortality analysis extends prior coverage of breast cancer in older adults, including evidence that nutrition-oriented perioperative nursing supports management of frailty and malnutrition in older women with cancer. It also aligns with prior findings on combined exercise for cancer-related fatigue and lean mass in breast cancer. Unlike those intervention-focused items, this analysis describes population-level mortality trends and disparities, confirming that breast cancer mortality declined from 71.58 to 50.83 per 100,000 between 1999 and 2020 but slowed after 2014. It addresses a gap in characterizing disparities among older adults, though causes remain unestablished.

A new report looked at breast cancer deaths among U.S. adults aged 65 and older. It used national death records covering 544,812 deaths, including 538,489 women and 6,323 men, from 1999 to 2020. This is a population analysis, not a clinical trial, so it can show patterns but cannot prove what caused them.

The combined death rate for men and women fell from 71.58 to 50.83 per 100,000 people. The drop was significant over the full period, but it slowed after 2014. For women, the pooled age-adjusted death rate was 99.84 per 100,000 women. For men, it was 1.70 per 100,000 men.

The report also points to ongoing differences in breast cancer death rates by age, race, ethnicity, and geography among older adults. It does not explain why these gaps exist. No safety or side effect information is included, since this is not a treatment study.

The main takeaway is that breast cancer mortality has improved over two decades, but progress has slowed and not everyone has benefited equally. The findings suggest a need for targeted strategies in screening, diagnosis, and geriatric cancer care. Readers should talk with their doctor about their own screening and risk.

What this means for you:
U.S. breast cancer death rates fell from 1999 to 2020, but the decline slowed after 2014 and disparities persist.

Common questions

Who was included in this breast cancer mortality report?

The analysis looked at U.S. adults aged 65 and older. It covered 544,812 total deaths, including 538,489 women and 6,323 men, using national death records from 1999 to 2020. It is a population-based report, not a clinical trial, so it describes patterns rather than testing a treatment.

What did the report find about breast cancer death rates over time?

The combined death rate for men and women declined from 71.58 to 50.83 per 100,000 people between 1999 and 2020. The decline was significant, but it slowed after 2014. For women, the pooled age-adjusted rate was 99.84 per 100,000 women. For men, it was 1.70 per 100,000 men.

Does this report explain why breast cancer death rates differ by race or location?

No. The report identifies persistent differences in breast cancer mortality by age, race, ethnicity, and geography among older adults, but it does not establish specific causes for these disparities. It suggests a need for targeted strategies in screening, diagnosis, and geriatric oncology care, but more research is needed to understand why the gaps exist.

Should I change my breast cancer screening based on this report?

This report does not provide personal medical advice. It is a population-level analysis of death records, not a study of screening or treatment. If you have questions about your own breast cancer risk or screening schedule, talk with your doctor, who can consider your personal and family history.

Study Details

Study typeGuideline
EvidenceLevel 5
PublishedSep 2026
View Original Abstract ↓
BackgroundBreast cancer remains a major cause of cancer mortality among older adults in the United States. Although overall breast cancer mortality has declined in recent decades, the extent to which these improvements have been shared across demographic and geographic subgroups among adults aged 65 years and older remains insufficiently characterized.MethodsWe conducted a population-based repeated cross-sectional mortality analysis using the CDC WONDER Underlying Cause of Death database from 1999 to 2020. Deaths due to breast cancer among U.S. adults aged 65 years and older were defined using ICD-10 code C50 as the underlying cause of death. Age-adjusted mortality rates (AAMRs) and age-specific crude mortality rates were calculated. Female-specific AAMRs were used as the primary outcome for demographic, geographic, state-level SDI panel, and descriptive frontier analyses; male breast cancer mortality was reported separately as a descriptive finding. Temporal trends were assessed using Joinpoint regression.ResultsFrom 1999 to 2020, 544,812 deaths due to breast cancer occurred among U.S. adults aged 65 years and older, including 538,489 deaths among women and 6,323 among men. The pooled female-specific AAMR was 99.84 per 100,000 women, compared with 1.70 per 100,000 men. Among older women, mortality increased with age, was highest among Black or African American women, and varied substantially across regions and jurisdictions. The combined-sex AAMR declined from 71.58 to 50.83 per 100,000 population, although the decline slowed after 2014. State-level analyses showed marked geographic and sociodemographic variation in female breast cancer mortality.ConclusionsBreast cancer mortality among older U.S. adults declined significantly between 1999 and 2020, but the increasing absolute number of deaths and persistent age, racial, ethnic, and geographic disparities indicate a continuing public health burden. Targeted strategies to improve equitable access to screening, timely diagnosis, guideline-concordant treatment, and geriatric oncology care are needed to further reduce mortality among older adults.
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