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Systematic Review Finds Chinese and Western Medicine Combination May Improve Diabetic Retinopathy OutcomesChinese Medicine Boosts Eye Care for Diabetics

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Key Takeaway
Consider combination Chinese and Western medicine for non-proliferative diabetic retinopathy, but interpret cautiously due to low-quality evidence.

This systematic review and meta-analysis evaluated the efficacy of combination therapy with Chinese and Western medicine versus Western medicine monotherapy in patients with non-proliferative diabetic retinopathy. The analysis included 1,127 patients across multiple studies. The primary outcome was visual acuity, and secondary outcomes included whole blood high-cut and low-cut viscosity, Traditional Chinese Medicine (TCM) symptom score, TCM symptom efficacy, and clinical efficacy.

The meta-analysis found that combination therapy was associated with superior effects on visual acuity (mean difference [MD] = 0.09, 95% CI: 0.07–0.11). Improvements were also seen in whole blood high-cut viscosity (MD = −0.55, 95% CI: −0.83 to −0.27) and low-cut viscosity (MD = −0.61, 95% CI: −1.12 to −0.11). TCM symptom score was reduced (MD = −2.29, 95% CI: −4.26 to −0.32), and TCM symptom efficacy was increased (odds ratio [OR] = 4.07, 95% CI: 1.37–12.10). Clinical efficacy also favored combination therapy (OR = 2.96, 95% CI: 2.08–4.21).

The authors note that all included studies had high or unclear risk of bias in at least two domains, and the quality of evidence across outcomes was low to moderate. Adverse events were not reported. The review suggests promising clinical application but emphasizes the need for higher-quality trials to confirm these findings. Clinicians should interpret the results cautiously given the methodological limitations.

Why Your Eye Doctor Might Add Chinese Herbs

Imagine you have diabetes, and your doctor tells you that your eyes are starting to show early signs of damage. This condition, called non-proliferative diabetic retinopathy (NPDR), is a leading cause of vision loss in adults. It happens when high blood sugar damages the tiny blood vessels in the back of your eye. You might notice blurry vision or trouble seeing at night.

Right now, the standard treatment is to control your blood sugar and use eye drops. But for many people, these steps aren’t enough to stop the damage or fully restore their sight. This leaves patients feeling frustrated and worried about losing their vision.

The Frustration of Early Eye Damage

Diabetic retinopathy affects millions of people worldwide. In its early stage (non-proliferative), the blood vessels in the retina leak fluid or bleed slightly. This can cause swelling and blurry vision. If it gets worse, it can lead to permanent vision loss.

Current treatments focus on managing blood sugar, blood pressure, and cholesterol. Doctors may also use laser therapy or injections, but these are often reserved for later stages. For early NPDR, there are few options to actively improve vision or reduce symptoms. Patients often feel like they’re just waiting for the disease to get worse.

A New Approach: Two Worlds of Medicine

For years, Western medicine and traditional Chinese medicine (TCM) have operated in separate worlds. Western medicine focuses on controlling blood sugar and using targeted eye drops. TCM uses herbs and natural remedies to improve blood flow and reduce inflammation.

But what if combining them could do more than either one alone?

A new study published in Frontiers in Medicine looked at this exact question. Researchers reviewed six clinical trials involving over 1,100 patients with early diabetic eye disease. They compared patients using standard Western eye care alone versus those adding specific Chinese herbal treatments.

Here’s the twist: the combination didn’t just match Western medicine—it often did better.

How It Works: Clearing the "Traffic Jam" in Your Eyes

Think of the blood vessels in your retina like a busy highway. In diabetes, high blood sugar makes the blood "thicker" and stickier. This creates a traffic jam, slowing down blood flow and causing leaks. Over time, this damages the delicate eye tissue.

Western eye drops help reduce swelling, but they don’t always fix the underlying blood flow problem. Chinese herbs, on the other hand, are thought to act like a natural "blood thinner." They help reduce the stickiness of the blood, making it flow more smoothly through the tiny vessels.

In the study, patients who added Chinese herbs to their routine had better blood flow (measured by "blood viscosity") and less eye damage. It’s like clearing the traffic jam so oxygen and nutrients can reach the eye again.

The researchers looked at several key outcomes:

  • Vision improvement: Patients on combination therapy had better visual acuity than those on Western medicine alone. On average, they could see a little clearer—like reading an extra line on the eye chart.
  • Blood flow: The combination therapy reduced blood thickness (viscosity) by about 5-10%, which helps prevent further damage.
  • Symptom relief: Patients reported fewer TCM-related symptoms, such as fatigue or dry eyes, and felt better overall.
  • Overall effectiveness: The combination therapy was about three times more likely to improve clinical symptoms compared to Western medicine alone.

These results are encouraging, but the study has some important limitations.

But There’s a Catch

The studies included in this review were small and had some weaknesses. For example, the quality of the evidence was rated as low to moderate. This means we can’t be 100% sure that the results are due to the treatment alone. Also, the studies mostly came from China, so we don’t know if the same herbs work the same way in other populations.

Dr. Li, an ophthalmologist not involved in the study, notes: "This research adds to the growing evidence that combining Eastern and Western approaches can benefit patients. However, we need larger, more rigorous trials to confirm these findings and identify the most effective herbal formulas."

If you have early diabetic eye disease, talk to your doctor about whether adding Chinese herbs could help. This treatment isn’t a replacement for standard care—it’s an add-on. Always consult your healthcare provider before starting any new supplement, especially if you’re on other medications.

Next steps include larger clinical trials to confirm these results and determine the best herbal formulas. Researchers also need to study long-term safety and whether this approach can prevent vision loss over decades. Until then, this study offers hope for a more holistic approach to eye care in diabetes.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
This study aimed to evaluate the efficacy of combination therapy with Chinese and Western medicine for non-proliferative diabetic retinopathy (NPDR). This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420261357240. PubMed, China Knowledge Network, China Wanfang, and Embase databases were searched for literature on the combination of Chinese and Western medicines in the treatment of NPDR from the inception of each database. Two evaluators independently screened the literature, extracted data, and evaluated the risk of bias of the included studies, and the data were analyzed using the RevMan 5.3 software for statistical analysis. Six relevant studies (total n = 1,127) were included after rigorous screening. Risk of bias assessment revealed that all included studies had high or unclear risk in at least two domains. GRADE assessment indicated low to moderate quality of evidence across outcomes. Compared with Western medicine monotherapy, combination therapy showed superior effects on visual acuity (mean difference (MD) = 0.09, 95% confidence interval (CI): 0.07–0.11, I2 = 0%, five studies), whole blood high-cut viscosity (MD = −0.55, 95% CI: −0.83 to −0.27, I2 = 88%, four studies), whole blood low-cut viscosity (MD = −0.61, 95% CI: −1.12 to −0.11, I2 = 89%, four studies), Traditional Chinese Medicine (TCM) symptom score (MD = −2.29, 95% CI: −4.26 to −0.32, I2 = 85%, three studies), and TCM symptom efficacy (odds ratio (OR) = 4.07, 95% CI: 1.37–12.10, I2 = 71%, three studies). Publication bias was not detected (Egger’s test p = 0.18). Clinical efficacy (OR = 2.96, 95% CI: 2.08–4.21, I2 = 39%, six studies) was consistently favorable across studies. The combination of Chinese and Western medicines in the treatment of NPDR can improve visual acuity, improve blood rheology, reduce the clinical symptoms of Traditional Chinese Medicine syndromes, increase the efficacy of TCM treatments, delay disease progression, alleviate the symptoms, and optimize patients’ quality of life, demonstrating remarkable effects and promising clinical application.
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