Mode
Text Size
Log in / Sign up

Systematic review and meta-analysis links higher prognostic nutritional index to better survival in non-small cell lung cancerHigher nutrition scores linked to longer life after lung cancer surgery

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note higher PNI associates with better survival in non-small cell lung cancer after resection.

This systematic review and meta-analysis examined the prognostic nutritional index (PNI) among patients with non-small cell lung cancer who underwent curative lung resection. The authors synthesized data from 11 studies to evaluate how PNI levels relate to survival outcomes in this surgical population.

The primary finding indicates that a higher PNI is significantly associated with longer overall survival. The pooled analysis reported a hazard ratio of 0.79 with a 95% confidence interval of 0.72 to 0.87. Secondary outcomes included recurrence-free survival and cancer-specific survival, though specific effect sizes for these were not detailed in the provided data.

The authors explicitly state that the observed relationship represents an association and caution against inferring causation. Safety data, including adverse events or tolerability, were not reported in the source material. The review highlights the potential utility of PNI as a prognostic marker but emphasizes the need for further research to confirm clinical relevance.

People with non-small cell lung cancer face a tough road after surgery. They need every advantage they can get to stay healthy. A new analysis of 11 studies offers a clue. It focuses on the prognostic nutritional index, or PNI. This score measures how well a person is eating and how strong their immune system is.

The data shows a clear pattern. Patients with a higher PNI score lived longer. The analysis found that a higher score was linked to better overall survival. It also connected to better recurrence-free survival and cancer-specific survival. These are important measures of how long a person stays disease-free and how long they live from cancer causes.

This finding matters for patients preparing for curative lung resection. It suggests that nutrition status before surgery is a key factor. The study did not report safety issues because it looked at existing data. It also noted that this is an association, not proof that changing the score will change the outcome. Still, it highlights a vital connection between nutrition and survival.

What this means for you:
Higher nutrition scores linked to longer life after lung cancer surgery

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
ObjectiveTo explore the prognostic value of the prognostic nutritional index (PNI) in patients undergoing curative surgery for non-small cell lung cancer (NSCLC) through a systematic review and meta-analysis.MethodsRelevant studies published up to October 2025 were searched in PubMed, Embase, Web of Science, and Cochrane. Observational studies assessing the association between PNI and overall, recurrence-free, or cancer-specific survival after curative resection of NSCLC were included. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was evaluated by the I² statistic, with sensitivity analyses and assessment for publication bias.ResultsA total of 11 studies were included in the analysis. Meta-analysis indicated that higher PNI significantly associated with longer OS (HR = 0.79, 95% CI: 0.72–0.87, P
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.