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Non-Small Cell Lung Cancer

Part of Extensive-Stage Small-Cell Lung Cancer

132 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Non-Small Cell Lung Cancer

570 trials tracked for Non-Small Cell Lung Cancer: 130 in phase 3 or 4 and 57 with published results. The most-cited published study has 5486 citations.

570Trials tracked
130Phase 3 & 4
0Recruiting
57With published results
Phase distribution
Phase 4 16 Phase 3 114 Phase 2 327 Phase 1 76 Other / NA 37
  1. Phase 3 Phase III Study (Tarceva®) vs Chemotherapy to Treat Advanced Non-Small Cell Lung Cancer in Patients With Mutations in the TK Domain of EGFR Completed · 5,486 cited
  2. Phase 3 Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042/KEYNOTE-042) Completed · 3,312 cited
  3. Phase 3 An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC) Completed · 2,820 cited
  4. Phase 3 A Global Study to Assess the Effects of MEDI4736 Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer Completed · 1,390 cited
  5. Phase 3 A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC Completed · 1,354 cited
  6. Phase 3 LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer Completed · 1,154 cited
Show 44 more trials
  1. Phase 3 ALTA-1L Study: A Study of Brigatinib Versus Crizotinib in Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-small Cell Lung Cancer (NSCLC) Participants Completed · 981 cited
  2. Phase 3 Study of Pembrolizumab (MK-3475) vs Placebo for Participants With Non-small Cell Lung Cancer After Resection With or Without Standard Adjuvant Therapy (MK-3475-091/KEYNOTE-091) Completed · 774 cited
  3. Phase 3 A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants Completed · 686 cited
  4. Phase 3 Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) Completed · 641 cited
  5. Phase 3 Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2) Completed · 640 cited
  6. Phase 3 LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib Completed · 567 cited
  7. Phase 3 A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407) Completed · 555 cited
  8. Phase 3 First-line Treatment of Participants With Stage IV Squamous Non-Small Cell Lung Cancer With Necitumumab and Gemcitabine-Cisplatin Completed · 481 cited
  9. Phase 3 Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200) Completed · 400 cited
  10. Phase 3 A Study of Tislelizumab in Combination With Chemotherapy Versus Chemotherapy in Advanced Lung Cancer Completed · 393 cited
  11. Phase 3 Efficacy Study of Nivolumab Compared to Docetaxel in Subjects Previously Treated With Advanced or Metastatic Non Small Cell Lung Cancer Completed · 357 cited
  12. Phase 3 Alectinib Versus Pemetrexed or Docetaxel in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Participants Previously Treated With Platinum-Based Chemotherapy and Crizotinib Completed · 334 cited
  13. Phase 3 Combinations of Cemiplimab (Anti-PD-1 Antibody) and Platinum-based Doublet Chemotherapy in Patients With Lung Cancer Completed · 320 cited
  14. Phase 3 A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Completed · 302 cited
  15. Phase 3 A Study Evaluating the Efficacy and Safety of Tislelizumab Versus Chemotherapy in Advanced Non-Squamous Non-small Cell Lung Cancer Completed · 282 cited
  16. Phase 3 A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) Completed · 251 cited
  17. Phase 3 Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598) Completed · 249 cited
  18. Phase 3 A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132) Completed · 186 cited
  19. Phase 3 Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3) Completed · 179 cited
  20. Phase 3 Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum Completed · 178 cited
  21. Phase 3 A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy Completed · 168 cited
  22. Phase 3 Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789) Completed · 165 cited
  23. Phase 3 Clinical Trial of YH25448(Lazertinib) as the First-line Treatment in Patients With EGFR Mutation Positive Locally Advanced or Metastatic NSCLC (LASER301) Completed · 153 cited
  24. Phase 3 ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer Completed · 141 cited
  25. Phase 3 First-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-Cisplatin Completed · 133 cited
  26. Phase 3 Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers Completed · 133 cited
  27. Phase 3 Comparison of Efficacy and Safety of Tislelizumab (BGB-A317) Versus Docetaxel as Treatment in the Second- or Third-line Setting in Participants With Non-Small Cell Lung Cancer (NSCLC) Completed · 114 cited
  28. Phase 3 Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR) Completed · 111 cited
  29. Phase 3 Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042/KEYNOTE-042)-China Extension Study Completed · 100 cited
  30. Phase 3 Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients With Stage II-III Non-Small Cell Lung Cancer Completed · 99 cited
  31. Phase 3 M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC) Completed · 97 cited
  32. Phase 3 Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007) Completed · 78 cited
  33. Phase 3 Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008) Completed · 78 cited
  34. Phase 3 Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer Completed · 76 cited
  35. Phase 3 Study of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small Cell Lung Cancer Previously Treated With an Anti-PD-L1/PD-1 Antibody and Platinum-Containing Chemotherapy Completed · 63 cited
  36. Phase 3 A Comparative Study Of PF-06439535 Plus Paclitaxel-Carboplatin And Bevacizumab Plus Paclitaxel-Carboplatin Patients With Advanced Non-Squamous NSCLC Completed · 63 cited
  37. Phase 3 A Study Comparing the Efficacy and Safety Between IBI308 and Docetaxel in Patients With Advanced or Metastatic NSCLC Completed · 59 cited
  38. Phase 3 A Study to Investigate Atezolizumab Subcutaneous in Patients With Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer Completed · 56 cited
  39. Phase 3 Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study Completed · 56 cited
  40. Phase 3 A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407)-China Extension Study Completed · 54 cited
  41. Phase 4 A Study of Atezolizumab (Tecentriq) to Investigate Long-term Safety and Efficacy in Previously-treated Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Completed · 48 cited
  42. Phase 3 Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality Completed · 47 cited
  43. Phase 4 An Expanded Access Program of Tarceva (Erlotinib) in Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) Completed · 34 cited
  44. Phase 3 A Study Comparing MB02 and Avastin® in Subjects With Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Completed · 27 cited

Showing the 50 most-cited and recently-updated of 570 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Extensive-Stage Small-Cell Lung Cancer

Related studies from across the Extensive-Stage Small-Cell Lung Cancer family.

Pembrolizumab-induced hypophysitis can cause arginine vasopressin deficiency unmasked by glucocorticoid therapy
Diabetes & Endocrinology Sys. Review
Pembrolizumab-induced hypophysitis can cause arginine vasopressin deficiency unmasked by glucocorticoid therapy Pembrolizumab Treatment Linked to Rare Hormone Deficiency in Lung Cancer
This case report and review describes a patient with metastatic lung adenocarcinoma who developed hypophysitis after pembrolizumab monothera…
A rare case of lung cancer treatment revealed a complex hormone deficiency that only appeared after the patient received steroid therapy.
Serplulimab induced grade 4 checkpoint inhibitor pneumonitis in an elderly patient with SCLC and COPD
Oncology Sys. Review
Serplulimab induced grade 4 checkpoint inhibitor pneumonitis in an elderly patient with SCLC and COPD New cancer treatment causes severe lung inflammation in elderly patients
This case report describes a grade 4 serplulimab-induced checkpoint inhibitor pneumonitis in an 80-year-old man with extensive-stage small c…
A new cancer drug caused severe, life-threatening lung inflammation in an 80-year-old man with existing lung disease.
Later-line antibody-drug conjugates show 25.7% objective response rate in advanced small-cell lung cancer
Allergy & Immunology Meta-analysis
Later-line antibody-drug conjugates show 25.7% objective response rate in advanced small-cell lung cancer Antibody-drug conjugates show activity in advanced small-cell lung cancer
This systematic review and meta-analysis evaluates later-line monotherapy with antibody-drug conjugates (ADCs) for advanced small-cell lung …
Antibody-drug conjugates show promise for treating advanced small-cell lung cancer, though they are associated with frequent clinical toxici…
Tarlatamab improves symptom and functional outcomes in extensive-stage small cell lung cancer
Oncology RCT
Tarlatamab improves symptom and functional outcomes in extensive-stage small cell lung cancer New trial shows tarlatamab improves symptoms for lung cancer patients
This Phase 3 randomized controlled trial of 509 adults with extensive-stage small cell lung cancer found that tarlatamab improved several pa…
A new trial shows tarlatamab helps patients with small cell lung cancer manage symptoms like coughing and chest pain better than standard ch…
Atezolizumab and lurbinectedin combinations show potential for superior progression-free survival in extensive-stage small cell lung cancer
Drug Pipeline Meta-analysis
Atezolizumab and lurbinectedin combinations show potential for superior progression-free survival in extensive-stage small cell lung cancer New Drug Combos Show Promise for Aggressive Small Cell Lung Cancer
This Bayesian network meta-analysis of 18 regimens in treatment-nađve patients with extensive-stage small cell lung cancer suggests that ate…
A massive analysis of 8,945 patients points to two drug cocktails that may extend survival in extensive-stage small cell lung cancer.
Gut-lung axis in lung cancer: soluble metabolites lead, neural pathways remain hypothetical
Oncology Sys. Review
Gut-lung axis in lung cancer: soluble metabolites lead, neural pathways remain hypothetical Gut Health Links May Influence Lung Cancer Treatment Paths
This narrative review with a systematic search examined 168 studies on the gut-lung axis in non-small-cell and small-cell lung cancer. Solub…
New research explores how the gut-lung axis and specific metabolites might play a role in managing lung cancer treatments.
Nab-paclitaxel, cisplatin, and pembrolizumab achieved pathologic complete response in a patient with small cell lung cancer
Oncology Sys. Review
Nab-paclitaxel, cisplatin, and pembrolizumab achieved pathologic complete response in a patient with small cell lung cancer New Treatment Approach Shows Success for a Rare Type of Lung Cancer
This case report describes a 61-year-old man with high-grade thoracic malignancy who achieved a pathologic complete response and undetectabl…
A 61-year-old man with a rare lung cancer showed a complete response after receiving a specific mix of drugs and surgery.
KRAS G12C inhibitors may remodel immunosuppressive tumor microenvironments into immunostimulatory states in KRAS-mutant tumors
Oncology Sys. Review
KRAS G12C inhibitors may remodel immunosuppressive tumor microenvironments into immunostimulatory states in KRAS-mutant tumors Targeted Drugs May Help Change Immune Environment in KRAS Tumors
This mini-review examines the impact of KRAS mutations and G12C inhibitors on the tumor immune microenvironment across PDAC, CRC, and LAC. T…
New research suggests that specific drugs targeting KRAS mutations may help reshape the immune environment around certain types of cancer.
PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases
Drug Pipeline Sys. Review
PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases Understanding the Role of PGE2 Signaling in Brain Health and Cancer
This systematic review examines the role of PGE2 signaling across neurological, oncological, and metabolic conditions. The findings indicate…
New research shows how different parts of a single protein pathway can either protect your brain or help tumors grow.
Surfactant protein D serves as a prognostic marker and potential therapeutic agent in various cancers
Allergy & Immunology Sys. Review
Surfactant protein D serves as a prognostic marker and potential therapeutic agent in various cancers Protein D shows promise in diagnosing and treating several cancers
This narrative review explores the role of Surfactant protein D (SP-D) across multiple malignancies, including lung adenocarcinoma and breas…
A specific protein called Surfactant protein D may help doctors identify lung cancer and fight cells in breast and leukemia cases.
B7-H3-targeted ADCs achieve 54% objective response rate in previously treated small cell lung cancer
Allergy & Immunology Meta-analysis
B7-H3-targeted ADCs achieve 54% objective response rate in previously treated small cell lung cancer B7-H3 Targeted Drugs Show Promise for Small Cell Lung Cancer
This systematic review and meta-analysis evaluates B7-H3-targeted antibody-drug conjugates for patients with previously treated small cell l…
New data suggests B7-H3 targeted therapies may offer higher response rates than standard treatments for patients with small cell lung cancer…
First-line immune checkpoint inhibitor combinations improve overall survival in extensive-stage small-cell lung cancer
Oncology Sys. Review
First-line immune checkpoint inhibitor combinations improve overall survival in extensive-stage small-cell lung cancer Immune checkpoint inhibitors combined with chemotherapy improve small cell lung cancer survival
This meta-analysis of 3,910 patients with extensive-stage small-cell lung cancer (ES-SCLC) found that first-line immune checkpoint inhibitor…
Combining immune checkpoint inhibitors with chemotherapy shows better survival rates for patients with extensive stage small cell lung cance…

Questions about Non-Small Cell Lung Cancer

Can morning timing of immune checkpoint infusions improve survival outcomes in metastatic non-small cell lung cancer patients?

Morning timing of immune checkpoint infusions is linked to better survival in metastatic non-small cell lung cancer, while other new drugs like magrolimab have not shown clear benefits.

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Does a phase III trial show sublobar resection is better than lobectomy for small peripheral non–small cell lung cancer?

Yes, a phase III trial (CALGB 140503) found sublobar resection noninferior to lobectomy for disease-free survival in small peripheral NSCLC ≤2 cm.

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How do bispecific antibodies and CAR T-cell therapy work for advanced non–small cell lung cancer?

Bispecific antibodies and CAR T-cell therapy are two immunotherapies being tested for advanced NSCLC; bispecific antibodies show more clinical progress, while CAR T faces challenges like toxicity and tumor trafficking.

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What does the research say about using chemotherapy versus immunotherapy for advanced Non-Small Cell Lung Cancer?

For advanced NSCLC, immunotherapy (especially pembrolizumab) is highly effective for high PD-L1 tumors, while chemotherapy remains a backbone; combining both may improve outcomes.

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How does high PD-L1 expression affect treatment choices for advanced Non-Small Cell Lung Cancer?

High PD-L1 expression (≥50%) often makes immunotherapy, such as pembrolizumab, a first-line option for advanced NSCLC, but other factors like mutations also guide treatment.

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Can you explain the global disparities in access to new therapies for advanced Non-Small Cell Lung Cancer?

Global disparities in access to new NSCLC therapies stem from differences in drug approval, cost, testing infrastructure, and healthcare system resources.

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Is camrelizumab associated with a higher risk of disease progression compared to pembrolizumab?

In nonsquamous advanced NSCLC, camrelizumab was linked to a higher risk of disease progression and death than pembrolizumab in second-line or later treatment, based on one real-world study.

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Does real-world data support using pembrolizumab for my advanced Non-Small Cell Lung Cancer?

Yes, real-world data from over 17,500 patients shows pembrolizumab is effective as first-line treatment for advanced NSCLC with high PD-L1 (≥50%), with median overall survival of 21 months and 29% survival at 5 years.

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See all 11 questions about Non-Small Cell Lung Cancer →

All Non-Small Cell Lung Cancer Articles