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Mingmu Dihuang Tang plus conventional treatment improved visual acuity and reduced complications in elderly cataract patientsTrial shows Mingmu Dihuang Tang plus Western medicine improves cataract markers

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Key Takeaway
Consider Mingmu Dihuang Tang as an adjunct to conventional therapy for improving visual acuity and reducing complications in cataract patients.

This randomized controlled trial evaluated the efficacy of Mingmu Dihuang Tang (MDT) combined with conventional Western medicine for treating cataract in elderly patients. The study included 120 participants. The intervention group received conventional treatment plus MDT, whereas the control group received conventional Western medicine alone. The follow-up duration was not reported.

The primary outcomes were not reported. Secondary outcomes included serum and aqueous humor levels of glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), nitric oxide, and inflammatory cytokines (IL-2, IL-6, TNF-\u03b1), as well as visual acuity, lens opacity, and complication rate.

Antioxidant activities (GSH-Px, CAT, SOD, TAC) were significantly higher in the experimental group compared to the control group with a P value less than 0.05. Nitric oxide concentrations were lower in the experimental group compared to the control group with a P value less than 0.05. IL-2, IL-6, and TNF-\u03b1 concentrations were also significantly lower in the experimental group compared to the control group, all with a P value less than 0.05.

Visual acuity recovery was superior in the MDT group compared to the control group. Lens clouding was reduced in the MDT group compared to the control group. The complication rate was 6.21% in the MDT group versus the control group, with a P value less than 0.05. Safety data, adverse events, and tolerability were not reported. The study demonstrated significant value for clinical application.

This randomized controlled trial looked at elderly patients with cataracts. The researchers compared standard Western medicine alone against a combination of that standard care plus Mingmu Dihuang Tang (MDT). The study included 120 participants. They measured changes in eye chemistry and vision over the course of the treatment.

The group receiving MDT showed significantly higher levels of antioxidant activities, including glutathione peroxidase, catalase, and superoxide dismutase. They also had lower levels of inflammatory markers like IL-6 and TNF-alpha. Nitric oxide levels were lower in the MDT group as well.

Patients taking the herbal supplement alongside conventional treatment had better visual acuity recovery and less lens clouding. The complication rate was 6.21% in the MDT group, which was significantly lower than in the control group. No adverse events were reported in the study.

While the results suggest value for clinical application, this trial has a small sample size and no long-term follow-up data. Readers should view these findings as promising but not definitive proof of a cure.

What this means for you:
Adding Mingmu Dihuang Tang to standard care improved vision recovery and reduced complications in this small trial.

Study Details

Study typeRct
Sample sizen = 120
EvidenceLevel 2
PublishedMay 2026
View Original Abstract ↓
BACKGROUND: Postoperative recovery from cataract surgery in elderly patients can be complicated by oxidative stress and inflammation, which may affect clinical outcomes. Mingmu Dihuang Tang (MDT), a traditional Chinese medicine formula, is postulated to offer antioxidative and anti-inflammatory benefits in this context. OBJECTIVES: This study aimed to evaluate the clinical efficacy of MDT as an adjunctive therapy for antioxidant and anti-inflammatory effects in elderly patients after cataract surgery. METHODS: In this randomized controlled trial, 120 patients were allocated to either a control group (conventional Western medicine) or an experimental group (conventional treatment plus MDT). Serum and aqueous humor levels of glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), nitric oxide and inflammatory cytokines (IL-2, IL-6, TNF-α) were measured. Visual acuity and lens opacity were also assessed. RESULTS: Compared to the control group, the experimental group demonstrated significantly higher antioxidant activities (GSH-Px, CAT, SOD, TAC) and IL-2 levels, alongside lower nitric oxide, IL-6 and TNF-α concentrations (P<0.05). The MDT group also showed superior visual acuity recovery, reduced lens clouding and a lower complication rate (6.21% vs. control, P<0.05). CONCLUSION: Adjunctive therapy with MDT enhances antioxidant capacity, modulates inflammation and improves clinical outcomes in cataract surgery recovery, demonstrating significant value for clinical application.
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