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Home › Conditions › Cataract

Cataract

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cataract

188 trials tracked for Cataract: 64 in phase 3 or 4 and 5 with published results. The most-cited published study has 289 citations.

188Trials tracked
64Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 33 Phase 3 31 Phase 2 9 Phase 1 2 Other / NA 113
  1. Phase 3 Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1) Completed · 289 cited
  2. Phase 3 Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2) Completed · 288 cited
  3. Phase 3 S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000 Completed · 52 cited
  4. Phase 3 Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification Completed · 5 cited
  5. Phase 3 Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification. Completed · 3 cited
  6. Phase 4 Dropless vs. Standard Drops Contralateral Eye Study Completed
Show 44 more trials
  1. Phase 4 Sedation Methods During Cataract Surgery Completed
  2. Phase 4 Clinical Investigation of the Bi Flex M Multifocal IOL Completed
  3. Phase 4 Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen Completed
  4. Phase 4 Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL. Completed
  5. Phase 4 No Drop Post-Op Cataract Surgery Completed
  6. Phase 4 Symfony vs Vivity in Dim Light Completed
  7. Phase 4 Effects of Bromfenac on Macular Thickness After Phacoemulsification Surgery Completed
  8. Phase 4 In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery Completed
  9. Phase 4 A Real-world Study of DEXYCU in the Treatment of Inflammation After Cataract Surgery Completed
  10. Phase 4 Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema Completed
  11. Phase 4 Visual Function After Implantation of Bilateral AcrySof ReSTOR Aspheric +3 Completed
  12. Phase 4 Clinical Evaluation of a New Aspheric Intraocular Lens. Completed
  13. Phase 4 Intraoperative Floppy Iris Syndrome Completed
  14. Phase 4 Visual Function After Implantation of Bilateral AcrySof® Toric Natural Intraocular Lens Completed
  15. Phase 4 Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction Completed
  16. Phase 4 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed
  17. Phase 4 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed
  18. Phase 4 ACRYSOF® ReSTOR® Aspheric +3.0 D Add Power Intraocular Lens (IOL) Completed
  19. Phase 4 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed
  20. Phase 4 Visual Function After Implantation of Bilateral AcrySoft ReSTOR Aspheric IOL Completed
  21. Phase 4 Visual Function With Bilateral AcrySof® ReSTOR® Aspheric SN6AD1 Completed
  22. Phase 4 Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA Completed
  23. Phase 4 Evaluation of 3 Intraocular Lenses Following Lens Extraction Completed
  24. Phase 4 A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms Completed
  25. Phase 4 Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL) Completed
  26. Phase 4 DisCoVisc Versus DuoVisc, Healon5 and AmVisc Plus Completed
  27. Phase 4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed
  28. Phase 4 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed
  29. Phase 4 A Comparison of Three Different Formulations of Prednisolone Acetate 1% Completed
  30. Phase 4 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed
  31. Phase 4 To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery. Completed
  32. Phase 4 Comparison of Functional Vision Provided by AMO Tecnis Z9000 and Alcon SA60AT Acrysof Completed
  33. Phase 3 Nepafenac Once Daily for Macular Edema - Study 2 Completed
  34. Phase 3 Nepafenac Once Daily for Macular Edema - Study 1 Completed
  35. Phase 3 Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss Completed
  36. Phase 3 Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery Completed
  37. Phase 3 Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children. Completed
  38. Phase 3 LE Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  39. Phase 3 Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery Completed
  40. Phase 3 Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery Completed
  41. Phase 3 Loteprednol Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  42. Phase 3 Loteprednol Etabonate Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  43. Phase 3 Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  44. Phase 3 Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed

Showing the 50 most-cited and recently-updated of 188 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Cataract: what the trials found

Clinical evidence for cataract management includes various pharmacological and surgical interventions. Dextenza 0.4mg Ophthalmic Insert demonstrated a mean anterior chamber cell/flare score of 0.25 and 0.22, with no participants experiencing an intraocular pressure (IOP) increase greater than 10mmHg above baseline [8, 12]. Bromfenac was evaluated for its effect on macular thickness, showing changes of 252.6 and 253.1 postoperatively at 6 weeks 9.

Procedural outcomes include the use of one-site peribulbar injection, which resulted in low pain scores for both local anesthetic injection (1.64; 1.58) and cataract surgery (1.06; 1.06), with high surgeon satisfaction scores 17. Other established interventions include Dexycu 7, Omidria 11, Pred-Gati-Brom 13, Midazolam + Ketamine 15, TriMoxiVanc 16, Dexamethasone Drug delivery system (Ozurdex) 18, and Sodium Carboxymethylcellulose, the latter of which was associated with specific fluorescein and lissamine green staining scores 19.

Various intraocular lenses (IOLs) have been evaluated in clinical settings, including Symfony IOL 10, Bi flex M multifocal IOL 14, Crystalens AO 21, and aspherical IOLs 22. Pred Forte was also utilized with reported percent changes in flare at resolution of 64.8%, 68.3%, and 65.7% 20.

Recent results — preliminary, needs further review

  • Argos achieved a postoperative manifest spherical equivalent refraction of ≤ ±0.50 D in 489 eyes, with 518 eyes achieving ≤ ±0.75D and 523 eyes achieving ≤ ±1.00D 1.
  • PODEYE TORIC Monofocal IOL showed a mean residual manifest cylinder of -0.286 compared to -0.813 in the control arm (p=<0.0001), with 115 participants achieving axis misalignment of less than 10 degrees 2.
  • RayOne EMV Toric IOL demonstrated an adjusted mean difference magnitude of residual manifest cylinder of -0.430 (p=<0.0001), with 92 and 98 patients showing axis misalignments of less than 10 and 20 degrees, respectively 6.
  • Other recently evaluated interventions include TECNIS Odyssey IOL 3, Quatera 700 4, and Clareon Monofocal 5.

For the clinician treating this condition

  • Dextenza 0.4mg Ophthalmic Insert is associated with low anterior chamber cell/flare scores and no significant increase in intraocular pressure (IOP) [8, 12].
  • One-site peribulbar injection is associated with low patient pain scores during both the local anesthetic administration and the cataract surgery procedure 17.
  • Toric IOL options, such as PODEYE TORIC and RayOne EMV, show statistically significant improvements in residual manifest cylinder compared to controls or baseline [2, 6].

AI synthesis of 20 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ocular morbidity prevalence of 43.1% among incarcerated populations in sub-Saharan Africa
Ophthalmology Meta-analysis
Ocular morbidity prevalence of 43.1% among incarcerated populations in sub-Saharan Africa Factors Linked to Eye Conditions in Sub-Saharan African Prisons
This meta-analysis of 3,361 individuals in sub-Saharan African prisons identifies a 43.1% prevalence of ocular morbidity. Key associated fac…
A study of over 3,000 people in African prisons found that age, past injuries, and length of stay are linked to common eye conditions.
Frontiers Oct 24, 2026
Nitrogen dioxide exposure is associated with increased risk of cataract outcomes in meta-analysis
Rheumatology Meta-analysis
Nitrogen dioxide exposure is associated with increased risk of cataract outcomes in meta-analysis Air Pollution Linked to Increased Risk of Cataracts
This meta-analysis evaluates the association between air pollution markers and cataract outcomes. The analysis found a significant associati…
New research suggests that exposure to common air pollutants like nitrogen dioxide may be linked to a higher risk of developing cataracts.
Frontiers Oct 3, 2026
GPT-5 leads LLMs on cataract patient education quality but readability remains suboptimal
Ophthalmology Sys. Review
GPT-5 leads LLMs on cataract patient education quality but readability remains suboptimal AI models provide varying quality of information for cataract patients
This systematic review evaluated responses from five large language models to 20 cataract FAQs, assessing readability, information quality, …
Not all AI models are equal when explaining cataract surgery. Some provide clearer information than others for patients seeking medical guid…
Frontiers Sep 25, 2026
Medicinal mushroom-derived compounds show potential for managing oxidative stress and inflammation in ocular conditions
Drug Pipeline Sys. Review
Medicinal mushroom-derived compounds show potential for managing oxidative stress and inflammation in ocular conditions Medicinal mushrooms show promise for several common eye conditions
This narrative review synthesizes evidence regarding medicinal mushroom-derived bioactive compounds, including polysaccharides and triterpen…
Medicinal mushrooms contain compounds that may protect the eyes from inflammation and damage, though more clinical trials are needed to conf…
Frontiers Sep 15, 2026
Capsular bag fixation is preferred over ciliary sulcus fixation for pediatric cataract surgery
Pediatrics Meta-analysis
Capsular bag fixation is preferred over ciliary sulcus fixation for pediatric cataract surgery Capsular Bag Fixation Preferred Over Ciliary Sulcus for Pediatric Cataracts
This meta-analysis of 843 children with cataracts compares capsular bag fixation to ciliary sulcus fixation. The authors conclude that capsu…
New data suggests that capsular bag fixation is the safer choice for children with cataracts to reduce risks like secondary glaucoma.
Sep 3, 2026
New IOL calculation formulas and adjustable technologies improve refractive outcomes in post-RK cataract patients
Nutrition & Obesity Medicine Sys. Review
New IOL calculation formulas and adjustable technologies improve refractive outcomes in post-RK cataract patients New Technologies Improve Vision for Patients with Cataracts and RK
This narrative review examines IOL power calculation challenges for patients with cataracts and prior radial keratotomy (RK). The authors co…
Advanced formulas and adjustable lenses are improving vision outcomes for patients who have both cataracts and previous radial keratotomy su…
Frontiers Aug 6, 2026
Surgical intervention improves refractive error and visual acuity in short eyes
Orthopedics & Sports Medicine Meta-analysis
Surgical intervention improves refractive error and visual acuity in short eyes Surgery Improves Vision Outcomes for Patients with Short Eyes
This systematic review and meta-analysis of 1,110 eyes indicates that surgical procedures significantly improve visual acuity and refractive…
New analysis shows surgical procedures can improve vision and eye measurements for patients with specific conditions like nanophthalmos and …
Frontiers Jul 24, 2026
Combined phacoemulsification and angle filtering reduce intraocular pressure and medication needs in glaucoma patients
Ophthalmology Meta-analysis
Combined phacoemulsification and angle filtering reduce intraocular pressure and medication needs in glaucoma patients Combined surgery lowers eye pressure better than cataract surgery alone
This meta-analysis of 14 randomized controlled trials evaluated combined phacoemulsification and angle filtering compared to phacoemulsifica…
For glaucoma patients with cataracts, combining two procedures in one surgery may better protect vision than cataract surgery alone.
Frontiers Jun 8, 2026
Mingmu Dihuang Tang plus conventional treatment improved visual acuity and reduced complications in elderly cataract patients
Ophthalmology RCT
Mingmu Dihuang Tang plus conventional treatment improved visual acuity and reduced complications in elderly cataract patients Trial shows Mingmu Dihuang Tang plus Western medicine improves cataract markers
This randomized controlled trial enrolled 120 elderly patients with cataract.
Adding Mingmu Dihuang Tang to standard care improved antioxidant levels and vision recovery in elderly patients with cataracts.
May 1, 2026
Chatbot plus brochures did not improve cataract knowledge or anxiety vs brochures alone
Primary Care & Family Medicine RCT
Chatbot plus brochures did not improve cataract knowledge or anxiety vs brochures alone A Chatbot Fails to Beat Brochures for Cataract Info
This pilot randomized controlled trial of 64 cataract surgery patients compared standard brochures plus a hospital-specific chatbot (Mina) t…
A new chatbot for cataract surgery patients did not teach them more than simple brochures and struggled with older users.
May 1, 2026
Ln-AISI, Ln-NAR, and Ln-MAR biomarkers linked to cataract surgery history in NHANES and clinical cohort
Nutrition & Obesity Medicine Cohort
Ln-AISI, Ln-NAR, and Ln-MAR biomarkers linked to cataract surgery history in NHANES and clinical cohort Inflammatory markers linked to cataract surgery history in large population study
This cohort study involving 8,194 NHANES participants and a clinical cohort examined inflammatory and nutritional biomarkers.
Higher levels of specific inflammatory markers were found in people who had cataract surgery, suggesting a potential link to the condition.
Frontiers Apr 28, 2026
Preliminary bench review suggests 4D ultrasound improves emulsification in dense cataract nuclei
Ophthalmology Sys. Review
Preliminary bench review suggests 4D ultrasound improves emulsification in dense cataract nuclei Could a new ultrasound mode break down the hardest cataract nuclei faster than current tools?
This ex vivo bench pilot review compares the Alcon UNITY system using 4D ultrasound against the Alcon CENTURION Vision System with torsional…
A new ultrasound mode broke down the hardest cataract nuclei 12 seconds faster and used far less energy than current tools in lab tests.
Frontiers Apr 16, 2026

Questions about Cataract

How do smoking and aging affect my risk for cataract and macular degeneration?

Smoking and aging both increase your risk for cataract and macular degeneration, with smoking amplifying the age-related risk, especially after age 75.

Full answer →
Will a hybrid extended depth-of-focus lens improve my near vision?

Yes, hybrid extended depth-of-focus (EDF) lenses improve near vision compared to standard monofocal lenses, but near vision may not be as sharp as with multifocal lenses.

Full answer →
Which biomarkers are linked to my history of cataract surgery?

Inflammatory-nutrition biomarkers Ln-AISI, Ln-NAR, and Ln-MAR are linked to cataract surgery history, along with CRP, smoking, and aging.

Full answer →

All Cataract Articles