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Home › Conditions › Cataract

Cataract

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cataract

188 trials tracked for Cataract: 64 in phase 3 or 4 and 5 with published results. The most-cited published study has 281 citations.

188Trials tracked
64Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 33 Phase 3 31 Phase 2 9 Phase 1 2 Other / NA 113
  1. Phase 3 Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1) Completed · 281 cited
  2. Phase 3 Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2) Completed · 281 cited
  3. Phase 3 S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000 Completed · 50 cited
  4. Phase 3 Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification Completed · 4 cited
  5. Phase 3 Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification. Completed · 3 cited
  6. Phase 4 Dropless vs. Standard Drops Contralateral Eye Study Completed
Show 44 more trials
  1. Phase 4 Sedation Methods During Cataract Surgery Completed
  2. Phase 4 Clinical Investigation of the Bi Flex M Multifocal IOL Completed
  3. Phase 4 Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen Completed
  4. Phase 4 Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL. Completed
  5. Phase 4 No Drop Post-Op Cataract Surgery Completed
  6. Phase 4 Symfony vs Vivity in Dim Light Completed
  7. Phase 4 Effects of Bromfenac on Macular Thickness After Phacoemulsification Surgery Completed
  8. Phase 4 In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery Completed
  9. Phase 4 A Real-world Study of DEXYCU in the Treatment of Inflammation After Cataract Surgery Completed
  10. Phase 4 Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema Completed
  11. Phase 4 Visual Function After Implantation of Bilateral AcrySof ReSTOR Aspheric +3 Completed
  12. Phase 4 Clinical Evaluation of a New Aspheric Intraocular Lens. Completed
  13. Phase 4 Intraoperative Floppy Iris Syndrome Completed
  14. Phase 4 Visual Function After Implantation of Bilateral AcrySof® Toric Natural Intraocular Lens Completed
  15. Phase 4 Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction Completed
  16. Phase 4 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed
  17. Phase 4 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed
  18. Phase 4 ACRYSOF® ReSTOR® Aspheric +3.0 D Add Power Intraocular Lens (IOL) Completed
  19. Phase 4 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed
  20. Phase 4 Visual Function After Implantation of Bilateral AcrySoft ReSTOR Aspheric IOL Completed
  21. Phase 4 Visual Function With Bilateral AcrySof® ReSTOR® Aspheric SN6AD1 Completed
  22. Phase 4 Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA Completed
  23. Phase 4 Evaluation of 3 Intraocular Lenses Following Lens Extraction Completed
  24. Phase 4 A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms Completed
  25. Phase 4 Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL) Completed
  26. Phase 4 DisCoVisc Versus DuoVisc, Healon5 and AmVisc Plus Completed
  27. Phase 4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed
  28. Phase 4 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed
  29. Phase 4 A Comparison of Three Different Formulations of Prednisolone Acetate 1% Completed
  30. Phase 4 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed
  31. Phase 4 To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery. Completed
  32. Phase 4 Comparison of Functional Vision Provided by AMO Tecnis Z9000 and Alcon SA60AT Acrysof Completed
  33. Phase 3 Nepafenac Once Daily for Macular Edema - Study 2 Completed
  34. Phase 3 Nepafenac Once Daily for Macular Edema - Study 1 Completed
  35. Phase 3 Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss Completed
  36. Phase 3 Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery Completed
  37. Phase 3 Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children. Completed
  38. Phase 3 LE Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  39. Phase 3 Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery Completed
  40. Phase 3 Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery Completed
  41. Phase 3 Loteprednol Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  42. Phase 3 Loteprednol Etabonate Ophthalmic Gel for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  43. Phase 3 Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed
  44. Phase 3 Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery Completed

Showing the 50 most-cited and recently-updated of 188 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Combined phacoemulsification and angle filtering reduce intraocular pressure and medication needs in glaucoma patients
Ophthalmology Meta-analysis
Combined phacoemulsification and angle filtering reduce intraocular pressure and medication needs in glaucoma patients Combined surgery lowers eye pressure better than cataract surgery alone
This meta-analysis of 14 randomized controlled trials evaluated combined phacoemulsification and angle filtering compared to phacoemulsifica…
For glaucoma patients with cataracts, combining two procedures in one surgery may better protect vision than cataract surgery alone.
Frontiers Jun 8, 2026
Mingmu Dihuang Tang plus conventional treatment improved visual acuity and reduced complications in elderly cataract patients
Ophthalmology RCT
Mingmu Dihuang Tang plus conventional treatment improved visual acuity and reduced complications in elderly cataract patients Trial shows Mingmu Dihuang Tang plus Western medicine improves cataract markers
This randomized controlled trial enrolled 120 elderly patients with cataract.
Adding Mingmu Dihuang Tang to standard care improved antioxidant levels and vision recovery in elderly patients with cataracts.
May 1, 2026
Chatbot plus brochures did not improve cataract knowledge or anxiety vs brochures alone
Primary Care & Family Medicine RCT
Chatbot plus brochures did not improve cataract knowledge or anxiety vs brochures alone A Chatbot Fails to Beat Brochures for Cataract Info
This pilot randomized controlled trial of 64 cataract surgery patients compared standard brochures plus a hospital-specific chatbot (Mina) t…
A new chatbot for cataract surgery patients did not teach them more than simple brochures and struggled with older users.
May 1, 2026
Ln-AISI, Ln-NAR, and Ln-MAR biomarkers linked to cataract surgery history in NHANES and clinical cohort
Nutrition & Obesity Medicine Cohort
Ln-AISI, Ln-NAR, and Ln-MAR biomarkers linked to cataract surgery history in NHANES and clinical cohort Inflammatory markers linked to cataract surgery history in large population study
This cohort study involving 8,194 NHANES participants and a clinical cohort examined inflammatory and nutritional biomarkers.
Higher levels of specific inflammatory markers were found in people who had cataract surgery, suggesting a potential link to the condition.
Frontiers Apr 28, 2026
Preliminary bench review suggests 4D ultrasound improves emulsification in dense cataract nuclei
Ophthalmology Sys. Review
Preliminary bench review suggests 4D ultrasound improves emulsification in dense cataract nuclei Could a new ultrasound mode break down the hardest cataract nuclei faster than current tools?
This ex vivo bench pilot review compares the Alcon UNITY system using 4D ultrasound against the Alcon CENTURION Vision System with torsional…
A new ultrasound mode broke down the hardest cataract nuclei 12 seconds faster and used far less energy than current tools in lab tests.
Frontiers Apr 16, 2026
Hybrid EDF intraocular lens matches monofocal for distance, improves intermediate and near vision
Nephrology Cohort
Hybrid EDF intraocular lens matches monofocal for distance, improves intermediate and near vision New Lens Gives You Clear Vision From Far To Near
In a prospective single-center comparative study, 37 eyes received the AM2UH hybrid extended depth-of-focus IOL and 36 eyes received the AW-…
A new hybrid lens offers clear distance and near vision without needing reading glasses after cataract surgery.
Frontiers Apr 16, 2026
Phacoemulsification with IOL implantation shows higher IOL prediction error in Chinese PACG patients
Ophthalmology
Phacoemulsification with IOL implantation shows higher IOL prediction error in Chinese PACG patients Why Some Glaucoma Patients Still Need Glasses After Cataract Surgery
An observational study of 165 Chinese primary angle closure glaucoma (PACG) patients and 53 cataract patients found that PACG patients had s…
Eye shape changes after glaucoma surgery can cause blurry vision post-cataract surgery, but new research identifies key measurements to impr…
medRxiv Apr 16, 2026
Simulator training improves surgical scores and reduces complications in cataract surgery training
Ophthalmology RCT
Simulator training improves surgical scores and reduces complications in cataract surgery training Can a surgical simulator train eye surgeons better than animal eyes?
A small RCT of 10 ophthalmologists in a hospital training program compared HelpMeSee simulator training to pig eye training for cataract sur…
Eye surgeons trained on a high-tech simulator performed cataract operations faster and with less swelling than those who practiced on animal…
Apr 13, 2026
Smoking, aging, and CRP levels associated with cataract and AMD comorbidity risk in 640 participants
Primary Care & Family Medicine Cohort
Smoking, aging, and CRP levels associated with cataract and AMD comorbidity risk in 640 participants Study links smoking and aging to higher risk of cataract and macular degeneration
This retrospective case-control study evaluated risk factors for cataract and age-related macular degeneration comorbidity in 640 participan…
Smoking combined with aging exponentially raises the risk of developing both cataracts and macular degeneration in people over 75.
Frontiers Apr 13, 2026
Regression-based keratometric prediction models showed refractive performance comparable to postoperative keratometry in pterygium and cataract cases
Ophthalmology Cohort
Regression-based keratometric prediction models showed refractive performance comparable to postoperative keratometry in pterygium and cataract cases You Can Predict Your Glasses Needs After Pterygium Surgery
This retrospective cohort analysis evaluated 20 unilateral eyes undergoing staged cataract surgery following pterygium excision.
A new math model predicts eye shape after pterygium surgery just as well as waiting for post-op scans, helping doctors plan vision needs bef…
Frontiers Apr 13, 2026
Smaller corneal incision linked to greater incisional thickening in cataract surgery for hard nuclei
Ophthalmology Cohort
Smaller corneal incision linked to greater incisional thickening in cataract surgery for hard nuclei Smaller Cuts May Slow Early Eye Healing
A retrospective cohort study of 100 eyes with hard cataracts compared 2.2 mm and 2.6 mm corneal incisions.
Smaller 2.2 mm cuts in hard cataract surgery don't save ultrasound energy or speed up early eye healing compared to 2.6 mm incisions.
Frontiers Apr 12, 2026
Phacoemulsification with endoscopic cyclophotocoagulation lowers IOP and medication needs versus phaco alone in PACG with cataract
Ophthalmology RCT
Phacoemulsification with endoscopic cyclophotocoagulation lowers IOP and medication needs versus phaco alone in PACG with cataract Combined glaucoma and cataract surgery shows modest pressure benefit in small study
This randomized controlled trial enrolled 66 patients with primary angle closure glaucoma and cataract.
Adding a laser treatment to cataract surgery lowered eye pressure and reduced medication needs for patients with a specific type of glaucoma…
Apr 6, 2026

Questions about Cataract

How do smoking and aging affect my risk for cataract and macular degeneration?

Smoking and aging both increase your risk for cataract and macular degeneration, with smoking amplifying the age-related risk, especially after age 75.

Full answer →
Will a hybrid extended depth-of-focus lens improve my near vision?

Yes, hybrid extended depth-of-focus (EDF) lenses improve near vision compared to standard monofocal lenses, but near vision may not be as sharp as with multifocal lenses.

Full answer →
Which biomarkers are linked to my history of cataract surgery?

Inflammatory-nutrition biomarkers Ln-AISI, Ln-NAR, and Ln-MAR are linked to cataract surgery history, along with CRP, smoking, and aging.

Full answer →

All Cataract Articles