Mode
Text Size
Log in / Sign up

Lidocaine cream combined with the Valsalva maneuver shows highest probability of reducing needle puncture painLidocaine and a breathing technique may reduce port needle pain

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note that lidocaine cream plus the Valsalva maneuver has high SUCRA probability but remains an exploratory finding.

This network meta-analysis evaluated several interventions, including lidocaine cream, lidocaine spray, the Valsalva maneuver, cryotherapy, and cutaneous stimulation therapy, for managing pain during non-invasive needle punctures in patients with a totally implantable venous access port (TIVAP). The analysis included 942 patients to compare various local and procedural techniques.

The study found that lidocaine cream combined with the Valsalva maneuver was associated with lower pain scores compared with placebo, cryotherapy, cutaneous stimulation therapy, and standard care, with a SUCRA probability of 93.3%. Additionally, lidocaine spray (79.6%), lidocaine cream (68.6%), and the Valsalva maneuver alone (66.5%) all yielded lower pain scores compared with standard care. Lidocaine cream specifically showed a higher SUCRA probability (68.6%) than cutaneous stimulation therapy (18.2%).

Several limitations impact the certainty of these findings, including a limited number of randomized controlled trials, a sparse evidence network, and suboptimal methodological quality in some included studies. There was also a lack of direct head--to-head comparisons between different interventions. Consequently, while lidocaine cream combined with the Valsalva maneuver showed high probability for effectiveness, the results are exploratory, and strong clinical recommendations cannot be made at present.

How this fits prior evidence

This finding addresses a gap in managing pain during needle punctures for TIVAP access. While prior coverage noted that intrauterine lidocaine reduces pain during hysteroscope insertion, this study specifically evaluates topical and procedural maneuvers for venous access port procedures. The results provide evidence for the efficacy of lidocaine cream combined with the Valsalva maneuver as a potential intervention for needle puncture pain.

Getting a needle into a medical port can be painful. For patients with implanted ports, finding the right way to dull that sting is important for comfort during necessary treatments. A large review of data involving 942 patients looked at several ways to manage this discomfort.

The study compared different methods, including lidocaine spray, cryotherapy (cold therapy), and cutaneous stimulation. The results showed that using lidocaine cream combined with the Valsalva maneuver—a specific breathing technique—was associated with lower pain scores than standard care or other treatments. Lidocaine spray and lidocaine cream alone also performed better than standard care.

While these findings are encouraging, it is important to note that the evidence is still early. The researchers found a limited number of trials and some studies had lower quality. Because there weren't many direct head-to-head comparisons between every method, these results should be viewed as exploratory rather than a final rule.

What this means for you:
Lidocaine cream combined with the Valsalva maneuver may offer better pain relief during needle punctures.

Common questions

What is the most effective way to reduce pain during a needle puncture?

The study found that lidocaine cream combined with the Valsalva maneuver was associated with lower pain scores compared to placebo, cryotherapy, cutaneous stimulation therapy, and standard care. However, because the evidence is currently exploratory and based on limited trials, you should talk to your doctor about which method is best for your specific situation.

Are there other options besides lidocaine cream?

Yes, the study also found that lidocaine spray, lidocaine cream alone, and the Valsalva maneuver alone all resulted in lower pain scores compared to standard care. Lidocaine cream specifically showed a higher probability of effectiveness than cutaneous stimulation therapy.

Is this treatment safe for patients with implanted ports?

The study did not report any specific adverse events or safety data regarding these methods. Because the findings are based on a limited number of trials and have low certainty, you should consult your medical team to discuss how these options fit into your care plan.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BackgroundThe totally implantable venous access port (TIVAP) is an infusion device that can be permanently implanted in the subcutaneous tissue. However, patients with a TIVAP often experience considerable pain during non-invasive needle puncture. Alleviating this procedure-related pain is therefore particularly important. This network meta-analysis compared the effectiveness of several common interventions for reducing pain during non-invasive needle puncture in patients with a TIVAP, aiming to provide evidence to support clinical practice.MethodsRandomized controlled trials investigating pain reduction during non-invasive needle puncture in patients with a TIVAP were included. Two researchers independently screened the literature and extracted data. Study quality was assessed using the Cochrane Risk of Bias 2.0 (RoB2) tool. The quality of evidence was evaluated with the CINeMA (Confidence in Network Meta-Analysis) framework. Data analyses were performed using Stata 14 software.ResultsSeven trials involving nine interventions and 942 patients were included. The network meta-analysis showed that, compared with placebo, cryotherapy, cutaneous stimulation therapy, and standard care, lidocaine cream combined with the Valsalva maneuver was associated with lower pain scores. Lidocaine spray, lidocaine cream, and the Valsalva maneuver alone also yielded lower pain scores compared with standard care. Lidocaine cream reduced pain scores compared with cutaneous stimulation therapy. Based on surface under the cumulative ranking curve (SUCRA) probabilities, the interventions ranked as follows: lidocaine cream combing with valsalva maneuver (93.3%) > lidocaine spray (79.6%) > lidocaine cream (68.6%) > valsalva maneuver (66.5%) > cold spray (51.3%) > placebo (33.3%) > cryotherapy (33.1%) > cutaneous stimulation therapy (18.2%) > standard care (6.1%).ConclusionsBased on the current evidence, lidocaine cream combined with the Valsalva maneuver had the highest probability of being the most effective among the evaluated interventions. However, the included randomized controlled trials were limited in number, the evidence network was sparse, the methodological quality of some studies was suboptimal, and direct head-to-head comparisons between different interventions were lacking. This finding should be regarded as an exploratory result derived from limited evidence and interpreted with caution. Therefore, strong clinical recommendations cannot be made at present. Larger, rigorously designed, and adequately blinded randomized controlled trials are needed to directly compare the most promising interventions (e.g., lidocaine cream combined with the Valsalva maneuver vs. lidocaine spray) and to employ standardized pain assessment tools together with clinically meaningful pain relief thresholds, in order to further validate these findings and guide clinical practice.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.