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Anesthesiology & Pain Medicine
Meta-analysis
Intrauterine lidocaine reduces pain during hysteroscope insertion and improves patient satisfaction
Lidocaine reduces pain during hysteroscope insertion
This meta-analysis of nine RCTs found intrauterine lidocaine significantly reduces pain during hysteroscope insertion and at 10 minutes post…
A review of nine trials finds lidocaine instillation cuts pain during hysteroscope insertion and boosts patient satisfaction, but its relief…
Jun 1, 2026
Drug Pipeline
Meta-analysis
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid
Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Frontiers
Apr 21, 2026
Emergency Medicine
Phase IV
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients
What's the best way to ease pain after skin graft surgery for burn patients?
A two-phase study (RCT and prospective cohort) in 74 burn patients with <20% TBSA burns compared liposomal bupivacaine injection and preoper…
Burn patients with minor injuries face intense donor site pain after skin graft surgery, but doctors haven't yet reported which numbing meth…
CT.gov
Apr 3, 2026
Neurology
Phase II
Phase 2 trial compares lidocaine/estradiol cream, nortriptyline, and combination for vestibulodynia subtypes
Can a cream or pill help women with chronic pelvic pain?
A 52-month, phase 2, randomized, double-blinded, placebo-controlled trial in 209 women with distinct vestibulodynia subtypes compared 5% lid…
Women with chronic pelvic pain may finally find relief as a new trial compares creams, pills, and combined treatments to personalize care fo…
CT.gov
Apr 3, 2026