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Home › Medications › lidocaine

lidocaine

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of lidocaine

83 trials tracked of lidocaine: 43 in phase 3 or 4 and 14 with published results. The most-cited published study has 477 citations.

83Trials tracked
43Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 35 Phase 3 8 Phase 2 13 Phase 1 3 Other / NA 24
  1. Phase 3 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia Completed · 477 cited
  2. Phase 3 Trial Comparing Impact of PENG Block on Quality of Recovery Compared to No-block for Primary Total Hip Arthroplasty Completed · 79 cited
  3. Phase 4 Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis Completed · 72 cited
  4. Phase 4 The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY) Completed · 67 cited
  5. Phase 4 MAST Trial: Multi-modal Analgesic Strategies in Trauma Completed · 55 cited
  6. Phase 4 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection Completed · 31 cited
Show 44 more trials
  1. Phase 4 Local Anesthetics for Pain Reduction Prior to IV Line Placement Completed · 27 cited
  2. Phase 4 Evaluation of Oral Midazolam in First-trimester Surgical Abortions Completed · 26 cited
  3. Phase 4 Intravenous Lidocaine and Ketorolac for Pain Management Completed · 25 cited
  4. Phase 4 Hydrocodone For Pain Control in First Trimester Surgical Abortion Completed · 25 cited
  5. Phase 4 Intravenous Lidocaine Randomized Comparative Effectiveness Trial Completed · 17 cited
  6. Phase 4 Intrauterine Lidocaine Infusion for Essure Sterilization Procedures Completed · 13 cited
  7. Phase 4 Comparison of Two Lidocaine Administration Techniques Completed · 11 cited
  8. Phase 4 Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain Completed · 11 cited
  9. Phase 4 Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection Completed
  10. Phase 4 Continuous Lidocaine Infusion for Management of Perioperative Burn Pain Completed
  11. Phase 4 Paracervical Block Versus No Paracervical Block During IUD Insertion Completed
  12. Phase 4 Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine Completed
  13. Phase 4 Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies Completed
  14. Phase 4 Buffered Lidocaine in Paracervical Blocks Completed
  15. Phase 4 Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain Completed
  16. Phase 4 Comparative Trial Via Tranforaminal Approach Versus Epidural Catheter Via Interlaminar Approach Completed
  17. Phase 4 Sphenopalatine Ganglion Blocks RCT Completed
  18. Phase 4 Pharmacokinetics of Lidocaine in Healthy Adults Completed
  19. Phase 4 Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures Completed
  20. Phase 4 Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury. Completed
  21. Phase 4 Effect of Knee Pain on Walking Biomechanics Completed
  22. Phase 4 A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder Completed
  23. Phase 4 Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol Completed
  24. Phase 4 Effects of Epidural Local Anesthetics on Propofol Induction Completed
  25. Phase 4 Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol Completed
  26. Phase 4 Greater Occipital Nerve Block for Migraine Prophylaxis Completed
  27. Phase 4 Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients Completed
  28. Phase 4 Brain Imaging of Lidoderm for Chronic Back Pain Completed
  29. Phase 4 Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation Completed
  30. Phase 4 The Impact of Pain Scores on Intrauterine Lidocaine Versus Normal Saline Infusion at the Time of IUD Placement Completed
  31. Phase 4 Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block Completed
  32. Phase 3 Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery Completed
  33. Phase 3 Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients Completed
  34. Phase 3 Subcutaneous Lidocaine For Cancer-Related Pain Completed
  35. Phase 3 Spasmodic Dysphonia Pain Completed
  36. Phase 3 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort Completed
  37. Phase 3 Paracervical Block in First Trimester Surgical Abortions Completed
  38. Phase 2 Intranasal Cocaine and Temperature Regulation During Exercise Completed
  39. Phase 2 PREMIX vs PREMED Intranasal Lidocaine and Midazolam Completed
  40. Phase 2 Cryoanesthesia for Intravitreal Injections Completed
  41. Phase 2 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Completed
  42. Phase 2 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed
  43. Phase 2 Dysport in Post-Surgical Neuralgia Completed
  44. Phase 2 Vinorelbine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Treatment and Liver Dysfunction Completed

Showing the 50 most-cited and recently-updated of 83 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Transconjunctival bleb needling with mitomycin C reduces intraocular pressure in pediatric congenital glaucoma
Ophthalmology Sys. Review
Transconjunctival bleb needling with mitomycin C reduces intraocular pressure in pediatric congenital glaucoma New surgical technique helps manage severe glaucoma in children
This case report describes a 9-year-old patient with refractory primary congenital glaucoma. Transconjunctival bleb needling with mitomycin …
A minimally invasive procedure helped lower high eye pressure in a child with severe glaucoma and a complex surgical history.
Frontiers Oct 11, 2026
Perioperative IV lidocaine cuts chronic postsurgical pain at 3 months but not 6 months
Rheumatology Meta-analysis
Perioperative IV lidocaine cuts chronic postsurgical pain at 3 months but not 6 months Lidocaine during surgery may reduce chronic pain after operations
This systematic review and meta-analysis of 1,391 adults found that perioperative intravenous lidocaine significantly reduced chronic postsu…
Giving patients lidocaine during surgery may lower the risk of developing chronic pain three months after a procedure.
Frontiers Sep 28, 2026
Intrathyroidal dexamethasone injection improves clinical efficacy and shortens remission time in subacute thyroiditis
Diabetes & Endocrinology Meta-analysis
Intrathyroidal dexamethasone injection improves clinical efficacy and shortens remission time in subacute thyroiditis Intrathyroidal injection shows better results for subacute thyroiditis
This network meta-analysis evaluated treatment options for subacute thyroiditis, comparing intrathyroidal dexamethasone (monotherapy or with…
A local injection of dexamethasone works faster and more effectively than oral prednisone for patients with subacute thyroiditis.
NEJM Sep 27, 2026
Propofol outperforms sevoflurane and midazolam in preventing delayed neurocognitive recovery during surgery
Drug Pipeline Meta-analysis
Propofol outperforms sevoflurane and midazolam in preventing delayed neurocognitive recovery during surgery Propofol May Offer Better Protection Against Post-Surgery Cognitive Issues
This meta-analysis of 9,636 patients evaluated 18 interventions for preventing delayed neurocognitive recovery. Propofol showed statisticall…
A large review of surgical data suggests that propofol may be more effective than other anesthetics at preventing delayed cognitive recovery…
Frontiers Sep 24, 2026
Lidocaine-esketamine infusion reduces movement-evoked pain and opioid consumption in hepatic resection patients
Anesthesiology & Pain Medicine RCT
Lidocaine-esketamine infusion reduces movement-evoked pain and opioid consumption in hepatic resection patients New drug combination reduces pain after liver surgery
This randomized controlled trial of 304 patients undergoing elective hepatic resections found that a lidocaine-esketamine infusion significa…
A new mix of lidocaine and esketamine may lower pain and opioid use for patients recovering from liver surgery during the first three days.
Sep 7, 2026
Intrauterine lidocaine significantly reduces pain during IUD insertion in nulliparous and parous women
Anesthesiology & Pain Medicine Meta-analysis
Intrauterine lidocaine significantly reduces pain during IUD insertion in nulliparous and parous women Lidocaine may reduce pain during IUD insertion for women
This meta-analysis of 651 women found that intrauterine anesthesia (IUA) significantly reduced pain during IUD insertion (SMD -0.47, 95% CI …
A local anesthetic called lidocaine could make the process of inserting an IUD much less painful for women during the procedure.
Sep 6, 2026
4% articaine improves anaesthetic success rates compared to 2% lidocaine in children with MIH
Anesthesiology & Pain Medicine Meta-analysis
4% articaine improves anaesthetic success rates compared to 2% lidocaine in children with MIH Kids' tooth pain: stronger numbing drug works better
This meta-analysis evaluates pharmacological and behavioral interventions for children and adolescents with molar-incisor hypomineralisation…
For kids with MIH, 4% articaine numbs better than 2% lidocaine, easing pain and anxiety during dental work.
Sep 6, 2026
Jet lidocaine reduces anxiety during peripheral venous access in meta-analysis of 5 trials
Psychiatry Meta-analysis
Jet lidocaine reduces anxiety during peripheral venous access in meta-analysis of 5 trials Jet Lidocaine Reduces Anxiety During Blood Draws
A meta-analysis of 5 randomized controlled trials found that jet lidocaine significantly reduces anxiety during peripheral venous access (SM…
A needle-free lidocaine spray may ease anxiety when getting an IV, but it doesn't reduce pain.
Jul 2, 2026
Lidocaine cream combined with the Valsalva maneuver shows highest probability of reducing needle puncture pain
Orthopedics & Sports Medicine Meta-analysis
Lidocaine cream combined with the Valsalva maneuver shows highest probability of reducing needle puncture pain Lidocaine and a breathing technique may reduce port needle pain
This network meta-analysis of 942 patients evaluated various interventions for lidocaine effectiveness during TIVAP needle punctures. Lidoca…
A combination of lidocaine cream and a specific breathing technique shows promise in reducing pain for patients during needle punctures.
Frontiers Jun 27, 2026
Intrauterine lidocaine reduces pain during hysteroscope insertion and improves patient satisfaction
Anesthesiology & Pain Medicine Meta-analysis
Intrauterine lidocaine reduces pain during hysteroscope insertion and improves patient satisfaction Lidocaine reduces pain during hysteroscope insertion
This meta-analysis of nine RCTs found intrauterine lidocaine significantly reduces pain during hysteroscope insertion and at 10 minutes post…
A review of nine trials finds lidocaine instillation cuts pain during hysteroscope insertion and boosts patient satisfaction, but its relief…
Jun 1, 2026
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid
Drug Pipeline Meta-analysis
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Frontiers Apr 21, 2026
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients
Emergency Medicine Phase IV
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients What's the best way to ease pain after skin graft surgery for burn patients?
A two-phase study (RCT and prospective cohort) in 74 burn patients with <20% TBSA burns compared liposomal bupivacaine injection and preoper…
Burn patients with minor injuries face intense donor site pain after skin graft surgery, but doctors haven't yet reported which numbing meth…
CT.gov Apr 3, 2026

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