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Surgical resection plus postoperative TACE yields recurrence-free status in rare primary clear cell liver carcinomaRare Liver Cancer Case Treated With Surgery and TACE

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Key Takeaway
Recognize that this single case cannot establish the role of TACE after resection in clear cell liver carcinoma.

This publication is a case report accompanied by a literature review, focused on primary clear cell carcinoma of the liver, a rare liver tumor, in a patient with hepatitis B-related cirrhosis. The patient was a 74-year-old woman with Child-Pugh class A cirrhosis.

The reported management was laparoscopic partial hepatectomy followed by postoperative TACE. At follow-up spanning 2022 to 2025, the patient was free of recurrence or metastasis, a single-case observation with no comparator and no reported effect size.

The authors emphasize that surgical resection is the mainstay of treatment and that histopathology with immunohistochemistry is essential for diagnosis. They explicitly caution that the role of TACE cannot be determined based on a single case.

Limitations acknowledged include the single case report design and small sample size. Adverse events, serious adverse events, discontinuations, and tolerability were not reported. Funding and conflicts of interest were not reported. The evidence is anecdotal and should not be used to infer treatment efficacy.

How this fits prior evidence

This case report does not confirm or extend prior coverage of hepatocellular carcinoma biomarkers or systemic therapy. Prior items addressed the cGAS-STING pathway in MASLD and HCC, 18F-FDG PET/CT SUVmax and microvascular invasion risk, 15 germline loci associated with HCC, and survival benefits of pembrolizumab, regorafenib, and cabozantinib in advanced HCC. It also follows coverage of refractory ascites and quality of life in advanced chronic liver disease. Instead, this report addresses a gap in the literature on the rare entity of primary clear cell carcinoma of the liver, describing surgical resection with postoperative TACE in a single patient with hepatitis B-related cirrhosis.

This is a single case report, so it cannot show that any treatment works for others. It describes one 74-year-old woman with hepatitis B related cirrhosis. She was diagnosed with primary clear cell carcinoma of the liver, a rare type of liver cancer. Doctors treated her with laparoscopic partial hepatectomy, a minimally invasive surgery to remove part of the liver, followed by TACE, a procedure that delivers chemotherapy directly into the liver's blood supply.

From 2022 to 2025, she remained free of recurrence or metastasis. The report does not describe any side effects or safety problems. It also does not report whether the TACE was necessary, since a single case cannot separate the effect of surgery from the effect of TACE.

The report stresses that surgery is the main treatment for this kind of cancer, and that careful tissue testing is needed to confirm the diagnosis. Because this is one patient, the results are early and uncertain. Readers should not assume this approach will work the same way for anyone else. People facing a liver cancer diagnosis should talk with their care team about their own options.

What this means for you:
One case report cannot show a treatment works; surgery remains the mainstay for this rare liver cancer.

Common questions

What is primary clear cell carcinoma of the liver?

It is a rare type of liver cancer. This case report describes a 74-year-old woman with hepatitis B related cirrhosis who was diagnosed with it. Doctors confirmed the diagnosis using tissue testing. Because it is uncommon, careful lab testing is important to tell it apart from other liver cancers.

What treatments did the patient receive?

She had laparoscopic partial hepatectomy, which is surgery to remove part of the liver through small openings. After surgery, she had TACE, a procedure that delivers chemotherapy directly into the liver's blood supply. The report does not say whether the TACE was required or how much it helped.

Did the cancer come back?

The report says she was free of recurrence or metastasis from 2022 to 2025. That is a good outcome for this one patient. However, a single case cannot show that the treatment will prevent cancer from returning in other people.

Were there any side effects?

The report does not describe any side effects, serious events, or treatment stops. That does not mean the treatments are risk-free. Surgery and TACE both carry risks, and anyone considering them should ask their doctor about what to expect.

Can I rely on this for my own treatment decisions?

No. This is one case report, which is the weakest kind of medical evidence. It cannot prove that surgery plus TACE works better than other options. Surgery is described as the main treatment for this cancer, but your care team is the best source of advice for your situation.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
BackgroundPrimary clear cell carcinoma of the liver (PCCCL) is an uncommon hepatocellular carcinoma (HCC) subtype that resembles extrahepatic clear cell tumors, posing diagnostic challenges.Case presentationA 74-year-old woman with hepatitis B–related cirrhosis (Child-Pugh class A) presented with acute abdominal pain and vomiting. Imaging revealed a hypervascular hepatic lesion with intralesional fat, while serum AFP was normal and CA125 mildly elevated. Laparoscopic partial hepatectomy was performed. Histology confirmed PCCCL, and immunohistochemistry supported hepatic origin while excluding metastatic renal carcinoma. The patient subsequently received two sessions of postoperative TACE as an individualized treatment and remained free of recurrence or metastasis during surveillance from 2022 to 2025.ConclusionPCCCL is rare and difficult to distinguish from conventional HCC or metastatic clear cell carcinoma. Histopathology with immunohistochemistry is essential for diagnosis. Surgical resection is the mainstay of treatment. Although this patient remained recurrence-free after postoperative TACE, the role of TACE cannot be determined based on a single case, and studies with larger sample sizes are still needed.
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