Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
Gut Microbiota Differences Linked to Primary Biliary Cholangitis
This meta-analysis of 1,057 participants found that patients with primary biliary cholangitis have significantly lower Shannon index values …
A large review of patient data shows that people with primary biliary cholangitis have significantly lower gut bacterial diversity than heal…
Systematic review shows intralesional vitamin D reduces steroid risks for keloid patients
Triamcinolone works better for keloids, but vitamin D spares skin damage
A meta-analysis of four trials found intralesional triamcinolone acetonide superior for scar improvement versus vitamin D. However, vitamin …
Triamcinolone acetonide improves keloid scars more than vitamin D, yet vitamin D lowers risks of skin thinning and color changes.
Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
Trained liver doctors provided care that matched specialists for patients with serious liver disease
A US trial found hepatologist-delivered palliative care noninferior to specialist care for improving quality of life in advanced liver disea…
Patients with advanced liver disease saw similar quality of life improvements when cared for by trained liver doctors versus specialists. Bo…
Endovascular interventions reduce rebleeding risk versus endoscopic cyanoacrylate injection in gastric variceal hemorrhage
Endovascular procedures reduce rebleeding risk for cirrhosis patients compared to injection therapy
This individual patient data meta-analysis compares endovascular interventions with endoscopic cyanoacrylate injection for gastric variceal …
A meta-analysis of 1,240 patients found endovascular procedures significantly lower rebleeding rates than injection therapy, though they car…
Antimicrobial resistance reaches 33.3% in cirrhosis patients with bacterial infections across global settings
Antimicrobial resistance is rising in cirrhosis patients worldwide
This systematic review and meta-analysis examines bacterial infections in 35,180 adult patients with cirrhosis globally. The analysis report…
A global analysis of 35,180 patients with cirrhosis shows rising antimicrobial resistance and varying mortality risks.
Combination therapy with fibrates and ursodeoxycholic acid improves biochemical markers in primary biliary cholangitis patients across multiple studies
Combination therapy improves biochemical markers in primary biliary cholangitis
An umbrella meta-analysis of meta-analyses involving 3,276 patients shows that adding fibrates to ursodeoxycholic acid significantly lowers …
Combining fibrates with ursodeoxycholic acid improves liver markers in primary biliary cholangitis patients, though survival data remain unc…
Review of antiviral and immunotherapeutic strategies for chronic hepatitis B
New antiviral strategies show promise for chronic hepatitis B infection
This narrative review synthesizes evidence on antiviral and immunotherapeutic strategies for chronic hepatitis B. The authors highlight func…
A review of new treatments suggests combination therapies may offer future value for managing chronic hepatitis B, cirrhosis, and liver canc…
Narrative review explores macrophage reprogramming for liver fibrosis and MASH
Scientists explore new ways to reprogram liver cells to heal damaged tissue and stop scarring
This narrative review summarizes macrophage reprogramming strategies for liver fibrosis and MASH. Approaches include gene modulation, pharma…
A recent review looks at fresh methods to change how liver immune cells behave. These changes could help heal liver scarring and improve hea…
Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
Half of liver disease patients battle severe fatigue and itching
This systematic review and meta-analysis evaluated symptom burden in 13178 patients with primary biliary cholangitis. Fatigue affected 51% o…
Over half of patients with primary biliary cholangitis face severe fatigue and itching, yet most never get proper treatment for these sympto…
Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
Patients with severe liver disease and sepsis face high risks and need careful care plans
This narrative review synthesizes evidence on sepsis in patients with end-stage liver disease and acute-on-chronic liver failure. It describ…
People with advanced liver sickness and sepsis often have weak immune systems and get hard-to-treat infections. Doctors say new treatments l…
Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
Early trial shows zibotentan plus dapagliflozin trended toward lowering blood pressure in cirrhosis patients
This Phase II randomized placebo-controlled exploratory study in 28 patients with compensated cirrhosis found that zibotentan 2.5 mg plus da…
An early study found that a combination drug lowered blood pressure in patients with compensated cirrhosis, though it did not conclusively i…
Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
App helps cirrhosis patients avoid hospital readmission
This randomized clinical trial enrolled 464 subjects (232 dyads) with cirrhosis in a multicenter setting.
A smartphone app cut avoidable hospital readmissions in half for cirrhosis patients, a new trial shows.
Questions about Cirrhosis
How common is depression among patients with liver cirrhosis?
Depression is very common in liver cirrhosis, affecting about 37% of patients globally, yet it often goes undiagnosed.
Full answer →Can the Patient Buddy App help reduce hospital readmissions for my cirrhosis?
Yes, the Patient Buddy App reduced avoidable hospital readmissions in cirrhosis patients by about half in a clinical trial, but discuss with your doctor if it's right for you.
Full answer →All Cirrhosis Articles
- Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
- Systematic review shows intralesional vitamin D reduces steroid risks for keloid patients
- Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
- Endovascular interventions reduce rebleeding risk versus endoscopic cyanoacrylate injection in gastric variceal hemorrhage
- Antimicrobial resistance reaches 33.3% in cirrhosis patients with bacterial infections across global settings
- Combination therapy with fibrates and ursodeoxycholic acid improves biochemical markers in primary biliary cholangitis patients across multiple studies
- Review of antiviral and immunotherapeutic strategies for chronic hepatitis B
- Narrative review explores macrophage reprogramming for liver fibrosis and MASH
- Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
- Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
- Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
- Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
- Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
- Systematic review and meta-analysis evaluates ML and DL models for diagnosing MASH and fibrosis
- Systematic review finds weak link between atypical antipsychotics and MASLD in youth
- Systematic review shows high rates of fibrosis and cirrhosis in children with Pi*ZZ alpha-1 antitrypsin deficiency
- PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
- Review of scRNA-seq applications in non-alcoholic fatty liver disease and hepatocellular carcinoma research
- L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
- Hepatic steatosis prevalence and impact in autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis
- Narrative review offers mechano-immunology framework for keloid management strategies
- Narrative review on T cell subsets in primary biliary cholangitis
- Influenza vaccine induces stronger immune responses in liver cirrhosis patients
- Systematic review links periodontitis to NAFLD progression and HCC risk
- Integrative review of Epimedium flavonoids in hepatitis and cirrhosis shows preclinical promise but lacks clinical validation
- Observational study links semaglutide dose and weight loss to lower liver disease risk
- Systematic review and meta-analysis on depression and anxiety prevalence in liver cirrhosis
- Review of liver disease immunomodulation strategies notes precision over broad suppression
- Meta-analysis links rare APOB variants to advanced MASLD, cirrhosis, and hepatocellular carcinoma across large cohorts
- Network meta-analysis compares preventive measures for esophageal variceal bleeding in 6510 cirrhosis patients
- PON1 genetic variants rs2057681 and rs854572 modulate PONase activity and dysmetabolic risk in MASLD
- Review of bile acid homeostasis regulation in liver disease and cancer
- Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
- Non-cirrhotic portal fibrosis identified in 32.6% of pre-cirrhotic primary biliary cholangitis patients in a retrospective analysis
- Machine learning models show moderate to high accuracy for predicting variceal bleeding in cirrhosis patients
- Nurse-assisted outpatient follow-up reduces 30-day readmissions but not mortality in decompensated cirrhosis
- Hospitalized malignant neoplasm patients show high comorbidity burden and distinct disease patterns across 163 Chinese hospitals
- First-in-human study finds VS-01 generally well tolerated in decompensated cirrhosis with ascites
- Efruxifermin shows superior fibrosis regression in compensated MASH cirrhosis compared to placebo in a network meta-analysis
- Novel nomogram predicts long-term survival after TIPS in decompensated cirrhosis
- Oral nutritional interventions associated with reduced clinical events in adults with cirrhosis
- Corticosteroids in cirrhotic shock show no mortality benefit but increase bleeding and organ failure risk
- Pilot trial finds no between-group muscle mass benefit from HMB supplement in cirrhosis sarcopenia
- SBRT as bridging therapy in advanced cirrhosis HCC patients shows 67% transplant eligibility at 1 year
- Continuous terlipressin infusion reduces treatment failure and rebleeding in acute variceal bleeding
- Perspective reviews emerging antifibrotic therapies for metabolic dysfunction-associated steatohepatitis
- Phase 1/2a trial tests oral idebenone safety in adults with NASH and fibrosis