In a prospective cohort, periampullary tumor surgery affected quality of life and survival metrics.
This prospective cohort study included 111 patients undergoing pancreaticoduodenectomy, either laparoscopic or open, for periampullary tumors at the University Medical Center of Ho Chi Minh City. The investigation assessed quality of life (QoL) changes and other outcomes from baseline through 12 months post-discharge. Exclusion criteria included total pancreatectomy, in-hospital mortality, and disease recurrence.
Regarding quality of life, the Physical component score declined from 67.29 to 54.69 at one month post-surgery (p = 0.04). Similarly, Emotional limitations of QoL declined from 70.17 to 54.18 at one month (p = 0.01). However, the QoL trajectory improved from three months onward, surpassing pre-treatment levels. The median hospital stay was 11 days (± 5 days), and the average disease-free survival was 20.42 months (± 13.4 months).
Safety analysis noted that postoperative fistulas occurred in 30.6% of patients, with one severe case reported. Other adverse events included cholangitis. The study limitations include the exclusion of patients with total pancreatectomy, in-hospital mortality, or disease recurrence. Funding and conflicts of interest were not reported.
Practice relevance suggests that preoperative and postoperative management of risk factors may enhance recovery and QoL outcomes. As a prospective cohort study, factors are associated with changes in quality of life rather than causally linked.
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