Novel insights into the clinical translation of BNCT combined with immunotherapy

This narrative review explores the potential of combining Boron neutron capture therapy with immunotherapy. The authors discuss how this combination might lead to massive anti-tumor responses compared to standard low-LET radiotherapy. They also describe a transformation of the tumor microenvironment from a cold to a hot state. Additionally, the review notes that this approach activates dendritic cells and CD8+ T-cells. These findings point toward promising future applications, such as pairing the therapy with CAR-T cell therapy or immune checkpoint inhibitors. The text offers novel insights into how these treatments could be translated into clinical practice. Because this is a narrative review, it summarizes existing ideas rather than reporting new patient data. Readers should view these results as conceptual directions for future research rather than proven medical facts. No specific safety data or patient numbers were reported in this overview. The main takeaway is that this combination strategy shows promise in theory, but more research is needed to confirm its benefits in real-world settings.